Niveles de oxido nitrico y compuestos afines en vasos umbilicales de fetos de gestantes complicadas con preeclampsia
Fecha
2011
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
En Ecuador existe una alta incidencia de pacientes con preeclampsia, desorden común del embarazo que complica aproximadamente un 7% de todas las gestaciones a nivel mundial. A pesar de numerosos estudios e intentos de intervención, esta patología sigue siendo una causa importante de morbi-mortalidad materno-fetal, tanto en países desarrollados, como en aquellos en vías de desarrollo. Está bien establecido que la alteración de la circulación placentaria puede llevar a un insuficiente nutrición fetal y concomitante alteración en el desarrollo fetal en mujeres complicadas con preeclampsia. El objetivo de este trabajo es determinar los niveles de Oxido Nítrico y compuestos afines en vasos umbilicales de los fetos de gestaciones complicadas con preeclampsia. Este será un estudio de tipo descriptivo correlacional con diseño experimental transversal de casos y controles que se llevará a cabo en el Hospital Gineco-Obstétrico Enrique C. Sotomayor conjuntamente con el apoyo del Instituto de Biomedicina de la Universidad Católica de Santiago de Guayaquil Ecuador y el Laboratorio Molecular Celular de Endocrinología Ginecológica de la Universidad de Pisa, Italia. El universo estudiado estará constituido por todas gestantes ingresadas al área de Embarazo de Alto Riesgo de dicha casa asistencial, siendo la muestra 30 de éstas que cumplan con ciertos criterios establecidos. Con cuyo resultado se podrá determinar si los niveles de Oxido Nítrico y compuestos afines se correlacionan con la severidad de la enfermedad y la resultante neonatal.
Due to the high incidence of preeclamptic patients on Ecuador, this is a disorder of pregnancy that is shown as complication of approximately 7% of all pregnancies around the world. Despite of several trials and many other ways, this pathologic status keeps being an important cause of morbidity/mortality of mother/fetus in developed countries as well as those in ways of development. It is well-established that alterations in the circulation of the placenta lead to fetal insufficient nutrition and concomitant alterations in fetal development in women complicated with preeclampsia. I have done this trial which objective is to determine nitrous oxide levels and other similar substances in fetuses’ umbilical cord vessels in pregnancies that are complicated with preeclampsia. This is a case-control trial that will take place in Hospital Gineco-Obstétrico Enrique C. Sotomayor together with the support of the Institute of Biomedicine of the Universidad Católica Santiago de Guayaquil and the Molecular Cellular Laboratory of Gynecologic Endocrinology of the University of Pisa, Italy. The universe of the trial will be constituted by all pregnant women admitted in the High Risk Pregnancy Area of the mentioned hospital, being 30 of these that meet certain criteria. With the obtained result, it will be possible to determine if the nitrous oxide levels and similar substances are correlated with the severity of the disease and the neonatal resultant.
Due to the high incidence of preeclamptic patients on Ecuador, this is a disorder of pregnancy that is shown as complication of approximately 7% of all pregnancies around the world. Despite of several trials and many other ways, this pathologic status keeps being an important cause of morbidity/mortality of mother/fetus in developed countries as well as those in ways of development. It is well-established that alterations in the circulation of the placenta lead to fetal insufficient nutrition and concomitant alterations in fetal development in women complicated with preeclampsia. I have done this trial which objective is to determine nitrous oxide levels and other similar substances in fetuses’ umbilical cord vessels in pregnancies that are complicated with preeclampsia. This is a case-control trial that will take place in Hospital Gineco-Obstétrico Enrique C. Sotomayor together with the support of the Institute of Biomedicine of the Universidad Católica Santiago de Guayaquil and the Molecular Cellular Laboratory of Gynecologic Endocrinology of the University of Pisa, Italy. The universe of the trial will be constituted by all pregnant women admitted in the High Risk Pregnancy Area of the mentioned hospital, being 30 of these that meet certain criteria. With the obtained result, it will be possible to determine if the nitrous oxide levels and similar substances are correlated with the severity of the disease and the neonatal resultant.
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EMBARAZO, OXIDO NITRICO, PREECLAMPSIA, VASOS UMBILICALES DE FETOS, MORTALIDAD MATERNA, MARTALIDAD NEONATAL, HOSPITAL GINECO-OBSTETRICO ENRIQUE C. SOTOMAYOR, CANTON GUAYAQUIL, ECUADOR