Estudio de la composición química en corteza de Mimusops sp
Fecha
2018
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
Mimusops L, es un género incluido en Sapotaceae, del cual se han informado 136 especies, pero por estrecha similitud molecular no se ha podido identificar la especie estudiada. El estudio realizado permitió informar, por primera vez, algunas características morfoanatomicas del polvo de la corteza y los parámetros físico-químicos, los cuales responden con los establecidos para las drogas vegetales. A través de Tamizaje Fitoquímico se detectaron compuestos grasos, fenólicos y terpenoides como metabolitos secundarios mayoritarios. La concentración de fenoles totales fue de 4,19 mg/mL y para flavonoides de 16,02 mg/mL. Se diseñó y aplicó un método de extracción y fraccionamiento, siendo el disolvente más adecuado el metanol. En la fracción hexanica se identificaron 45 compuestos, de los cuales la cumarina (6-Metiloctahidro 2H-1 benzopirano 2-ona), la loganina (iridoide) y los sesquiterpenoides α-zingibereno y el Friedelan se reportan por primera vez en el género. La capacidad antioxidante por el método de DPPH fue de 75.98%. El extracto acuoso de la corteza no indujo Toxicología Aguda Oral (TAO) ni Dérmica (TAD) observable en los animales de experimentación
Mimusops L, is a genus included in Sapotaceae, of which 136 species have been reported, but by close molecular similarity the species studied has not been identified. The study made it possible to report, for the first time, some morphoanatomical characteristics of the bark powder and the physico-chemical parameters, which correspond to those established for plant drugs. Through Phytochemical Screening, fatty, phenolic and terpenoid compounds were detected as major secondary metabolites. The concentration of total phenols was 4.19 mg / mL and for flavonoids of 16.02 mg / mL. An extraction and fractionation method was designed and applied, methanol being the most suitable solvent. In the hexanic fraction, 45 compounds were identified, of which coumarin (6-Methyloctahydro 2H-1- benzopyran-2-one), loganine (iridoid) and sesquiterpenoid-α-zingiberene and Friedelan are reported for the first time in the genre. The antioxidant capacity by the DPPH method was 75.98%. The aqueous extract of the bark did not induce Acute Oral Toxicology (TAO) or Dermal Toxicology (TAD) observable in the experimental animals
Mimusops L, is a genus included in Sapotaceae, of which 136 species have been reported, but by close molecular similarity the species studied has not been identified. The study made it possible to report, for the first time, some morphoanatomical characteristics of the bark powder and the physico-chemical parameters, which correspond to those established for plant drugs. Through Phytochemical Screening, fatty, phenolic and terpenoid compounds were detected as major secondary metabolites. The concentration of total phenols was 4.19 mg / mL and for flavonoids of 16.02 mg / mL. An extraction and fractionation method was designed and applied, methanol being the most suitable solvent. In the hexanic fraction, 45 compounds were identified, of which coumarin (6-Methyloctahydro 2H-1- benzopyran-2-one), loganine (iridoid) and sesquiterpenoid-α-zingiberene and Friedelan are reported for the first time in the genre. The antioxidant capacity by the DPPH method was 75.98%. The aqueous extract of the bark did not induce Acute Oral Toxicology (TAO) or Dermal Toxicology (TAD) observable in the experimental animals
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CORTEZA, FENÓLICOS, MIMUSOPS, TOXICIDAD AGUDA ORAL, TOXICIDAD AGUDA DÉRMICA