Características clínicas, serológicas y epidemiológicas en pacientes con Sarcoma de Kaposi asociado a vih/sida en el Hospital Dr. José Daniel Rodríguez Maridueña estudio a realizarse en el período 2014 - 2017
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2018
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Medicina
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El Sarcoma de Kaposi (SK) es la neoplasia con mayor frecuencia en pacientes con VIH, su frecuencia ha disminuido gracias al uso de la terapia antirretroviral, las manifestaciones de la enfermedad y su desenlace guardan relación con el estado inmunológico de los pacientes. Objetivo: El objetivo de este trabajo investigativo es determinar la característica clínicas, serológicas y epidemiológicas de los pacientes con SK asociado a VIH/SIDA. Metodología: Estudio descriptivo, retrospectivo, no experimental, de corte transversal, realizado en pacientes con diagnóstico de VIH y Sarcoma de Kaposi, del Hospital Dr. José Rodríguez Maridueña durante el período 2014 -2017. Resultados: Se estableció que la mayor parte de los pacientes son de sexo masculino, de entre 22 a 31 años de edad, heterosexuales, que presentaban comorbilidades asociadas al VIH. El SK de variedad cutánea representa el 52% de los casos y el visceral el 25%, según tipificación la clase T1S1 corresponde al 56% de los casos; la media del IMC de la población fue de 17 kg/m2, el 41% tenía desnutrición grado 3 y 38% desnutrición grado 1. Se determinó que 22% de pacientes tenían antecedentes de abandono de TARGA, en cuanto a las características serológicas en su mayoría se presentaron cifras menores a 200 cell/ul CD4, y cargas virales superiores a 50000. Existe relación entre las características serológicas y los factores de desenlace (alta, fallecimiento). Conclusión: Las características de los pacientes con SK asociado a VIH/SIDA estudiados son coincidentes con el perfil clínico, epidemiológico y serológico encontrado en otros estudios y series de caso a nivel mundial.
Kaposi's sarcoma (KS) is the most frequent neoplasm in patients with HIV, its frequency has decreased thanks to the use of antiretroviral therapy, the manifestations of the disease and its outcome are related to the immunological status of patients. Objective: The objective of this research work is to determine the clinical, serological and epidemiological characteristics of patients with KS associated with HIV / AIDS. Methodology: A descriptive, retrospective, non-experimental, cross-sectional study was carried out in patients diagnosed with HIV and Kaposi's sarcoma, from the Dr. José Rodríguez Maridueña Hospital during the period 2014-2017. Results: It was established that the majority of patients are male, between 22 and 31 years of age, heterosexual, who had comorbidities associated with HIV. The SK of cutaneous variety represents 52% of the cases and the visceral 25%, according to classification the class T1S1 corresponds to 56% of the cases; the average BMI of the population was 17 kg / m2, 41% had malnutrition grade 3 and 38% malnutrition grade 1. It was determined that 22% of patients had a history of abandonment of HAART, in terms of serological characteristics in their Most of the figures were lower than 200 cell / ul CD4, and viral loads higher than 50000. There is a relationship between the serological characteristics and the outcome factors (discharge, death). Conclusion: The characteristics of the patients with KS associated to HIV / AIDS studied are coincident with the clinical, epidemiological and serological profile found in other studies and case series worldwide.
Kaposi's sarcoma (KS) is the most frequent neoplasm in patients with HIV, its frequency has decreased thanks to the use of antiretroviral therapy, the manifestations of the disease and its outcome are related to the immunological status of patients. Objective: The objective of this research work is to determine the clinical, serological and epidemiological characteristics of patients with KS associated with HIV / AIDS. Methodology: A descriptive, retrospective, non-experimental, cross-sectional study was carried out in patients diagnosed with HIV and Kaposi's sarcoma, from the Dr. José Rodríguez Maridueña Hospital during the period 2014-2017. Results: It was established that the majority of patients are male, between 22 and 31 years of age, heterosexual, who had comorbidities associated with HIV. The SK of cutaneous variety represents 52% of the cases and the visceral 25%, according to classification the class T1S1 corresponds to 56% of the cases; the average BMI of the population was 17 kg / m2, 41% had malnutrition grade 3 and 38% malnutrition grade 1. It was determined that 22% of patients had a history of abandonment of HAART, in terms of serological characteristics in their Most of the figures were lower than 200 cell / ul CD4, and viral loads higher than 50000. There is a relationship between the serological characteristics and the outcome factors (discharge, death). Conclusion: The characteristics of the patients with KS associated to HIV / AIDS studied are coincident with the clinical, epidemiological and serological profile found in other studies and case series worldwide.
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SARCOMA DE KAPOSI, VIRUS DE INMUNODEFICIENCIA HUMANA, CARGA VIRAL, DESNUTRICION, EPIDEMIOLOGIA DESCRIPTIVA, ESTUDIOS RETROSPECTIVOS, HOSPITAL DE INFECTOLOGIA DR. JOSE DANIEL RODRIGUEZ MARIDUEÑA, CANTON GUAYAQUIL, ECUADOR, SINDROME DE INMUNODEFICIENCIA ADQUIRIDA, ANTIGENOS CD4