Correlación de las dosis bajas de Sugammadex versus anticolinesterásicos para la reversión del bloqueo neuromuscular en la educación de la anestesia general en pacientes oncológicos en el ION SOLCA Guayaquil
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2016
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Con la aparición del Sugammadex para la reversión del bloqueo neuromuscular, se han obviado en gran manera los efectos indeseables de los anticolinesterásicos dando seguridad al paciente tanto en la educción de la anestesia como en el postoperatorio. El costo del Sugammadex en la dosis sugerida por el fabricante, ha sido motivo de continuar el uso de anticolinesterásicos, utilizar el Sugammadex en dosis inferiores o combinar ambos fármacos.
En este estudio se busca comprobar que las dosis utilizadas en los pacientes sometidos a anestesia general a pesar de ser inferiores a la sugerida da una reversión eficaz del bloqueo neuromuscular así como evita complicaciones del postoperatorio del paciente.
Para comprobarlo se realizará un estudio de tipo analítico, correlacional, retrospectivo con el análisis de las historias clínicas de los pacientes oncológicos sometidos a anestesia general en el I.O.N. SOLCA con el objetivo de comprobar que la educción de la anestesia general con dosis bajas de Sugammadex es tan efectiva como la realizada con anticolinesterásicos a dosis terapéuticas obviando los efectos indeseables de estos últimos. Como resultado se obtuvo que no hubo diferencia significativa entre las dosis bajas de sugammadex y la dosis terapéutica de anticolinesterásicos con un intervalo de confianza mayor a 95% en donde se obtuvieron complicaciones en un 3,44% del sugammadex versus un 8,6% de los anticolinesterásicos convirtiendo al Sugammadex en una opción valedera en la reversión del bloqueo neuromuscular.
With the upcoming of Sugammadex for neuromuscular blockade reversal, the undesirable effects of anticholinesterase drugs have been obviated in a great way, giving more security to the patient´s outcome of general anesthesia and in the patient´s postoperatory. The cost of sugammadex using the suggested manufacturer´s dose it’s been a motive to continue the use of anticholinesterase drugs, the use of Sugammadex in low doses and the combination of both. This research tries to prove that neverthless the usage of low dose Sugammadex on patients summited to general anesthesia, you can still get an effective neuromuscular blockade reversal and the avoidance of postoperatory complications for the patient. To prove this, an analytic, correlational, retrospective study will be held with the analysis of medical charts of oncological patients going through general anesthesia at the I.O.N. SOLCA with the goal to prove that the awakening from general anesthesia with low dose Sugammadex is as effective as the therapeutical dose of cholinesterase inhibitors but putting off the non wanted side effects of this kind of drugs. As a result we obtained that there was no significant difference between low dose Sugammadex and therapeutical cholinesterase inhibitor drugs with a confidence interval greater tan 95% in which complications were held in 3,44% of sugammadex patients against an 8,6% of cholinesterase inhibitor patients, turning Sugammadex in a valuable option for neuromuscular block reversión.
With the upcoming of Sugammadex for neuromuscular blockade reversal, the undesirable effects of anticholinesterase drugs have been obviated in a great way, giving more security to the patient´s outcome of general anesthesia and in the patient´s postoperatory. The cost of sugammadex using the suggested manufacturer´s dose it’s been a motive to continue the use of anticholinesterase drugs, the use of Sugammadex in low doses and the combination of both. This research tries to prove that neverthless the usage of low dose Sugammadex on patients summited to general anesthesia, you can still get an effective neuromuscular blockade reversal and the avoidance of postoperatory complications for the patient. To prove this, an analytic, correlational, retrospective study will be held with the analysis of medical charts of oncological patients going through general anesthesia at the I.O.N. SOLCA with the goal to prove that the awakening from general anesthesia with low dose Sugammadex is as effective as the therapeutical dose of cholinesterase inhibitors but putting off the non wanted side effects of this kind of drugs. As a result we obtained that there was no significant difference between low dose Sugammadex and therapeutical cholinesterase inhibitor drugs with a confidence interval greater tan 95% in which complications were held in 3,44% of sugammadex patients against an 8,6% of cholinesterase inhibitor patients, turning Sugammadex in a valuable option for neuromuscular block reversión.
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Anestesia general, Bloqueo neuromuscular, Sugammadex, Anticolinesterásicos, Pacientes incurables, Epidemiología analítica, Estudios retrospectivos, Hospital SOLCA de Guayaquil, Cantón Guayaquil, Ecuador