Niveles séricos de progesterona en gestantes complicadas con amenaza de parto pretérmino Hospital Gineco-Obstétrico Enrique C. Sotomayor 2009 - 2011
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2012
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
El parto pretérmino es la causa del 70% de muertes neonatales que no resulten de malformaciones congénitas letales y del 50% de secuelas neurológicas a largo plazo; su incidencia mundial oscila entre el 6% y 12% de todos los nacimientos. La etiología y el manejo sigue siendo causa de discusión y todos los esfuerzos van dirigidos a su prevención. Existen criterios que la disminución de progesterona podría tener cierta relación con el parto prematuro, es por ello que actualmente se ha promulgado la administración exógena de ésta hormona en su manejo clínico, pero hay pocas investigaciones sobre los valores circulantes en sangre, su relación con los factores de riesgo y con la resultante materno-neonatal. El objetivo del presente estudio fué conocer los niveles séricos de progesterona en gestantes complicadas con amenaza de parto pretérmino (APP). Es un proyecto de tipo descriptivo y correlacional, de diseño no experimental, longitudinal y retrospectivo. Se llevó a cabo en Cuidados Intermedios I,II y Sala Santa Rita del Hospital GinecoObstétrico Enrique C. Sotomayor 2009 - 2011, la muestra es de 100 pacientes con diagnóstico de APP, de quienes se obtuvo el suero sanguíneo para su respectivo análisis y se hizo mínimo un control materno hasta el nacimiento con el fin de calcular el tiempo transcurrido desde la toma. Se demostró que el nivel sérico de progesterona en las pacientes del estudio fue 152.18 ng/dl, el antecedente de parto pretérmino y la infección de vías urinarias se asociaron con bajos niveles de la hormona, existe correlación lineal entre los niveles séricos de progesterona y la edad gestacional, sin embargo las gestantes con niveles más elevados al ingreso independientemente de la edad gestacional fueron las que llegaron al termino.
Preterm birth causes 70% of neonatal deaths not resulting from lethal congenital malformations and 50% of long-term neurological sequelae, its worldwide incidence varies between 6% and 12% of all births. The etiology and management remains a matter of discussion and all efforts are aimed at prevention. There are criteria that the decrease in progesterone might have some relationship with preterm birth, which is why it has now passed the exogenous administration of this hormone in clinical management, but there is little research on the circulating levels in blood, their relationship with risk factors and the resulting maternal and neonatal. The aim of this study was to determine serum progesterone levels in pregnant women complicated by preterm labor (APP). This project is a descriptive and correlational, not experimental design, longitudinal and retrospective. Took place in Intermediate Care I, II and Santa Rita Room of Obstetric-Gynecologic Hospital Enrique C. Sotomayor 2009 - 2011, the sample is 100 patients with APP, from whom serum was obtained for examination and control was minimal until the birth mother in order to calculate the time elapsed since the shot. It was demonstrated that the serum level of progesterone in the study patients was 152.18 ng / dl, history of preterm labor and urinary tract infection were associated with low hormone levels, there is linear correlation between serum progesterone and gestational age, however pregnant women with higher income levels regardless of gestational age were those that reached the end.
Preterm birth causes 70% of neonatal deaths not resulting from lethal congenital malformations and 50% of long-term neurological sequelae, its worldwide incidence varies between 6% and 12% of all births. The etiology and management remains a matter of discussion and all efforts are aimed at prevention. There are criteria that the decrease in progesterone might have some relationship with preterm birth, which is why it has now passed the exogenous administration of this hormone in clinical management, but there is little research on the circulating levels in blood, their relationship with risk factors and the resulting maternal and neonatal. The aim of this study was to determine serum progesterone levels in pregnant women complicated by preterm labor (APP). This project is a descriptive and correlational, not experimental design, longitudinal and retrospective. Took place in Intermediate Care I, II and Santa Rita Room of Obstetric-Gynecologic Hospital Enrique C. Sotomayor 2009 - 2011, the sample is 100 patients with APP, from whom serum was obtained for examination and control was minimal until the birth mother in order to calculate the time elapsed since the shot. It was demonstrated that the serum level of progesterone in the study patients was 152.18 ng / dl, history of preterm labor and urinary tract infection were associated with low hormone levels, there is linear correlation between serum progesterone and gestational age, however pregnant women with higher income levels regardless of gestational age were those that reached the end.
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Mujeres embarazadas, Niveles séricos, Progesterona, Complicaciones del embarazo, Amenaza de parto prematuro, Epidemiología descriptiva, Estudios retrospectivos, Hospital Gineco-Obstétrico Enrique C. Sotomayor, Cantón Guayaquil, Ecuador