Evaluación de la absorción intestinal de microemulsiones estabilizadas con Tween 80 y lecitina de soya para la incorporación del gemfibrozilo
Fecha
2019
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
El gemfibrozilo, es un fármaco muy utilizado para el tratamiento de la hipercolesterolemia. A pesar de ello, presenta algunos problemas que limitan su uso, como la baja solubilidad en agua lo que dificulta la biodisponibilidad. Como alternativa para mejorar las limitaciones; las microemulsiones son sistemas termodinámicamente estables, de gran interés ya que pueden actuar como vehículos de liberación de fármacos. El presente trabajo tuvo como finalidad realizar un estudio experimental ex vivo, empleando el modelo del saco intestinal invertido. El método se realizó utilizando cobayos, los cuales fueron mantenidos en ayunas por un periodo de 8 horas con agua ad libitum. Los animales fueron anestesiados con
ketamina/diazepam (100mg/5mg) para la remoción del intestino. Los resultados mostraron que las MEs aumentaron la absorción intestinal del GFZ tanto para el intestino delgado (ID) como en el colon. Con los resultados presentados, se sugiere que las microemulsiones son potenciales transportadores de fármacos lipofílicos.
Gemfibrozil is a very suitable drug for the treatment of hypercholesterolemia. Oespite this, we present sorne problems that limit its use, such as the low solubility in water that hinders bioavailability. As an alternative to improve the limitations; Microemulsions are thermodynamically stable systems of great interest and can act as drug delivery vehicles. The purpose of this work was to carry out an ex vivo experimental study, using the inverted intestinal sac model. The method was performed using guinea pigs, which were maintained in a time of 8 hours with water ad libitum. Animals were anesthetized with ketamine / diazepam (100 mg / 5 mg) for bowel removal. The results improved as the srnall intestine (ID) as in the colon. With the results of the results, the results of the microemulsions and the transporters of lipophilic drugs.
Gemfibrozil is a very suitable drug for the treatment of hypercholesterolemia. Oespite this, we present sorne problems that limit its use, such as the low solubility in water that hinders bioavailability. As an alternative to improve the limitations; Microemulsions are thermodynamically stable systems of great interest and can act as drug delivery vehicles. The purpose of this work was to carry out an ex vivo experimental study, using the inverted intestinal sac model. The method was performed using guinea pigs, which were maintained in a time of 8 hours with water ad libitum. Animals were anesthetized with ketamine / diazepam (100 mg / 5 mg) for bowel removal. The results improved as the srnall intestine (ID) as in the colon. With the results of the results, the results of the microemulsions and the transporters of lipophilic drugs.
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ABSORCIÓN INTESTINAL, GEMFIBROZILO, MICROEMULSIONES, SACO INTESTINAL INVERTIDO