Determinación de artritis reumatoide mediante técnicas de factor reumatoide y anticuerpos antinucleares en niños
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2012
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Tecnología Médica
Resumen
La presente investigación permitió que los pacientes que se hacen atender en el hospital Roberto Gilbert padeciendo Artritis Reumatoide en jóvenes, dimos a conocer que es una afección heterogénea de inicio y curso variables, es la causa más frecuente de artritis crónica de comienzo en la edad pediátrica y afecta con mayor frecuencia al sexo femenino. La etiología es aún desconocida, pero el factor genético se considera importante. El curso de la ARJ es bastante variable y su tipo se establece en los primeros seis meses de evolución. Los períodos de actividad alternan con remisiones parciales y la mayoría de los pacientes entran en remisión permanente antes de llegar a la edad adulta. Se han identificado varios factores que determinan la persistencia y la severidad de la enfermedad. Los pacientes que presentan uno ó más de estos factores, se consideran de “alto riesgo” y por lo tanto requieren seguimiento y tratamiento más estrictos. Los síntomas de la artritis reumatoide juvenil pueden aparecer durante episodios (brotes), o pueden ser crónicos y continuos. El diagnóstico de la ARJ es básicamente clínico y se requiere un alto índice de sospecha para la identificación de estos pacientes ya que no hay ningún examen paraclínico que descarte o confirme la enfermedad. El factor reumatoideo no es un marcador diagnóstico importante. Tiene un valor diagnóstico limitado, ya que sólo se encuentra positivo en 10-15% de todos los casos, pero se considera un factor pronóstico que se asocia a formas severas y persistentes de la enfermedad. Algunos niños tienen proteínas especiales en la sangre llamadas Anticuerpos antinucleares, donde nos acogimos para dar una determinación específica de artritis reumatoide.
The present investigation allowed that the patients that are treated in the Roberto Gilbert hospital suffering from Rheumatoid Arthritis in young people, we announced that it is a heterogeneous condition of variable onset and course, it is the most frequent cause of chronic arthritis of beginning in the pediatric age and most often affects female sex. The etiology is still unknown, but the genetic factor is considered important. The course of the ARJ is quite variable and its type is established in the first six months of evolution. The periods of activity alternate with partial remissions and most patients go into permanent remission before reaching adulthood. Several factors that determine the persistence and severity of the disease have been identified. Patients who have one or more of these factors are considered "high risk" and therefore require more strict monitoring and treatment. Symptoms of juvenile rheumatoid arthritis may appear during episodes (outbreaks), or they may be chronic and continuous. The diagnosis of JRA is basically clinical and a high index of suspicion is required for the identification of these patients since there is no paraclinical examination that rules out or confirms the disease. Rheumatoid factor is not an important diagnostic marker. It has a limited diagnostic value, since it is only positive in 10-15% of all cases, but it is considered a prognostic factor that is associated with severe and persistent forms of the disease. Some children have special proteins in the blood called Antinuclear Antibodies, where we took shelter to give a specific determination of rheumatoid arthritis.
The present investigation allowed that the patients that are treated in the Roberto Gilbert hospital suffering from Rheumatoid Arthritis in young people, we announced that it is a heterogeneous condition of variable onset and course, it is the most frequent cause of chronic arthritis of beginning in the pediatric age and most often affects female sex. The etiology is still unknown, but the genetic factor is considered important. The course of the ARJ is quite variable and its type is established in the first six months of evolution. The periods of activity alternate with partial remissions and most patients go into permanent remission before reaching adulthood. Several factors that determine the persistence and severity of the disease have been identified. Patients who have one or more of these factors are considered "high risk" and therefore require more strict monitoring and treatment. Symptoms of juvenile rheumatoid arthritis may appear during episodes (outbreaks), or they may be chronic and continuous. The diagnosis of JRA is basically clinical and a high index of suspicion is required for the identification of these patients since there is no paraclinical examination that rules out or confirms the disease. Rheumatoid factor is not an important diagnostic marker. It has a limited diagnostic value, since it is only positive in 10-15% of all cases, but it is considered a prognostic factor that is associated with severe and persistent forms of the disease. Some children have special proteins in the blood called Antinuclear Antibodies, where we took shelter to give a specific determination of rheumatoid arthritis.
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Artritis reumatoide, Anticuerpos antinucleares, Pediatria, Hospital de Niños Dr. Roberto Gilbert Elizalde, Cantón Guayaquil, Ecuador, Factor reumatoideo