Dosis efectiva de citoprotección gástrica de extractos acuosos de malva en úlceras inducidas por alcohol en animales de experimentación
Fecha
2019
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
El efecto farmacológico de un medicamento ya sea de origen natural o sintético depende de las características propias del fármaco y del paciente, por ello es imprescindible definir la correlación entre el efecto observado y la dosis empleada, con el fin de evaluar la respuesta del fármaco para determinar su eficacia. Este estudio busca determinar la dosis efectiva de citoprotección gástrica que producen los extractos acuosos de Malva sylvestris y pseudolavatera en animales de experimentación, para ello se procedió a separar a los biomodelos en 13 grupos de cinco miembros cada uno, los cuales tuvieron previamente un periodo de aclimatación. Los tratamientos fueron administrados por seis días y el agente ulcerogénico (alcohol) fue suministrado el último día de prueba, al concluir los tratamientos se sacrificaron todos los grupos de biomodelos teniendo en cuenta las normas de ética sobre la experimentación animal. Se efectuaron análisis microscópicos y macroscópicos, se calculó los porcentajes de inhibición de úlceras gástricas, donde se demostró que el control positivo (sucralfato 1g/kg) alcanzó un 97% de inhibición, mientras que los grupos tratados con Malva sylvestris y pseudolavatera a dosis de 500 mg/kg alcanzaron un 68% de inhibición sin diferencias significativas entre ellas. A dosis inferiores (200, 80 mg/kg) Malva pseudolavatera presento mayor inhibición en comparación a Malva sylvestris. Esta actividad antiulcerosa se debe a la gran cantidad de mucilagos y flavonoides presentes en la planta. Con estos resultados podemos recalcar que el extracto de Malva pseudolavatera posee una eficacia antiulcerosa mayor a los extractos de Malva sylvestris.
The pharmacological effect of a drug of either natural or synthetic origin depends on the characteristics of the drug and the patient, therefore it is essential to define the correlation between the observed effect and the dose used, in order to evaluate the response of the drug to Determine its effectiveness. This study seeks to determine the effective dose of gastric cytoprotection produced by the aqueous extracts of Malva sylvestris and pseudolavatera in experimental animals, for which the biomodels were separated into 13 groups of five members each, which previously had a period of acclimatization. The treatments were administered for six days and the ulcerogenic agent (alcohol) was supplied on the last day of testing, at the conclusion of the treatments all groups of biomodels were sacrificed taking into account the ethical standards on animal experimentation. Microscopic and macroscopic analyzes were performed, the percentages of gastric ulcer inhibition were calculated, where it was demonstrated that the positive control (1g / kg sucralfate) reached 97% inhibition, while the groups treated with Malva sylvestris and pseudolavatera at doses of 500 mg / kg reached 68% inhibition without significant differences between them. At lower doses (200, 80 mg / kg) Malva pseudolavatera presented greater inhibition compared to Malva sylvestris. This antiulcer activity is due to the large number of mucilages and flavonoids present in the plant. With these results we can emphasize that the extract of Malva pseudolavatera has an antiulcer efficacy greater than the extracts of Malva sylvestris.
The pharmacological effect of a drug of either natural or synthetic origin depends on the characteristics of the drug and the patient, therefore it is essential to define the correlation between the observed effect and the dose used, in order to evaluate the response of the drug to Determine its effectiveness. This study seeks to determine the effective dose of gastric cytoprotection produced by the aqueous extracts of Malva sylvestris and pseudolavatera in experimental animals, for which the biomodels were separated into 13 groups of five members each, which previously had a period of acclimatization. The treatments were administered for six days and the ulcerogenic agent (alcohol) was supplied on the last day of testing, at the conclusion of the treatments all groups of biomodels were sacrificed taking into account the ethical standards on animal experimentation. Microscopic and macroscopic analyzes were performed, the percentages of gastric ulcer inhibition were calculated, where it was demonstrated that the positive control (1g / kg sucralfate) reached 97% inhibition, while the groups treated with Malva sylvestris and pseudolavatera at doses of 500 mg / kg reached 68% inhibition without significant differences between them. At lower doses (200, 80 mg / kg) Malva pseudolavatera presented greater inhibition compared to Malva sylvestris. This antiulcer activity is due to the large number of mucilages and flavonoids present in the plant. With these results we can emphasize that the extract of Malva pseudolavatera has an antiulcer efficacy greater than the extracts of Malva sylvestris.
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GASTROPROTECTOR, ANTIULCERANTE, MALVA PSEUDOLAVATERA