Enterobacterias productoras de betalactamasas de espectro extendido (blee) en pacientes diagnosticados con infección de vías urinarias SOLCA-Guayaquil, marzo-junio 2013
Fecha
2015
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Las infecciones de vías urinarias causadas por enterobacterias son consideradas patologías comunes tanto para hombres como mujeres. La alta tasa de incidencia de estas enfermedades infecciosas en diferentes grupos de edad y el surgimiento de resistencias a los antibióticos por parte de bacterias representan actualmente un gran problema para las sociedades. La Organización Mundial de la Salud (OMS) ha declarado que el fenómeno de la resistencia antimicrobiana debe constituirse una prioridad de la salud pública en el mundo. El propósito de este estudio es identificar la presencia de enterobacterias productoras de BLEE, susceptibilidad de las especies aisladas, así como la frecuencia de enterobacterias productoras de BLEE basados en variables edad, sexo y procedencia de la muestra.
Las infecciones de vías urinarias causadas por enterobacterias son consideradas patologías comunes tanto para hombres como mujeres. La alta tasa de incidencia de estas enfermedades infecciosas en diferentes grupos de edad y el surgimiento de resistencias a los antibióticos por parte de bacterias representan actualmente un gran problema para las sociedades. La Organización Mundial de la Salud (OMS) ha declarado que el fenómeno de la resistencia antimicrobiana debe constituirse una prioridad de la salud pública en el mundo (1).
La producción de Betalactamasas de Espectro Extendido (BLEE) en diferentes cepas de enterobacterias Gram negativas como por ejemplo Escherichia coli y Klebsiella pneumoniae se relaciona con la resistencia bacteriana y la inefectividad de tratamientos con antibióticos frente a infecciones en las diferentes áreas de salud a nivel mundial. Las enzimas catalíticas betalactamasas actúan rompiendo el enlace amídico del anillo betalactámico de los antibióticos como por ejemplo las penicilinas haciendo que pierda su actividad de acción bactericida. Otro factor que ha incrementado la resistencia bacteriana es la facilidad de transferencia de los genes de
resistencia contra antibióticos por medio de plásmidos, transposones e integrones
Urinary tract infections caused by enterobacteria are considered common pathologies for both men and women. The high incidence rate of these infectious diseases in different age groups and the emergence of resistance to antibiotics by bacteria are currently a major problem for societies. The World Health Organization (WHO) has stated that the phenomenon of antimicrobial resistance must be a priority of public health in the world. The purpose of this study is to identify the presence of ESBL-producing enterobacteria, susceptibility of isolated species, as well as the frequency of ESBL-producing enterobacteria based on variables age, sex and origin of the sample. Urinary tract infections caused by enterobacteria are considered common pathologies for both men and women. The high incidence rate of these infectious diseases in different age groups and the emergence of resistance to antibiotics by bacteria are currently a major problem for societies. The World Health Organization (WHO) has stated that the phenomenon of antimicrobial resistance must be a priority of public health in the world (1). The production of Extended Spectrum Betalactamases (ESBL) in different strains of Gram-negative enterobacteria such as Escherichia coli and Klebsiella pneumoniae is related to bacterial resistance and the ineffectiveness of antibiotic treatments against infections in different health areas worldwide . The beta-lactamase catalytic enzymes act by breaking the amide linkage of the beta-lactam ring of antibiotics such as penicillins, causing them to lose their bactericidal activity. Another factor that has increased bacterial resistance is the ease of transfer of genes from two resistance against antibiotics by means of plasmids, transposons and integrons
Urinary tract infections caused by enterobacteria are considered common pathologies for both men and women. The high incidence rate of these infectious diseases in different age groups and the emergence of resistance to antibiotics by bacteria are currently a major problem for societies. The World Health Organization (WHO) has stated that the phenomenon of antimicrobial resistance must be a priority of public health in the world. The purpose of this study is to identify the presence of ESBL-producing enterobacteria, susceptibility of isolated species, as well as the frequency of ESBL-producing enterobacteria based on variables age, sex and origin of the sample. Urinary tract infections caused by enterobacteria are considered common pathologies for both men and women. The high incidence rate of these infectious diseases in different age groups and the emergence of resistance to antibiotics by bacteria are currently a major problem for societies. The World Health Organization (WHO) has stated that the phenomenon of antimicrobial resistance must be a priority of public health in the world (1). The production of Extended Spectrum Betalactamases (ESBL) in different strains of Gram-negative enterobacteria such as Escherichia coli and Klebsiella pneumoniae is related to bacterial resistance and the ineffectiveness of antibiotic treatments against infections in different health areas worldwide . The beta-lactamase catalytic enzymes act by breaking the amide linkage of the beta-lactam ring of antibiotics such as penicillins, causing them to lose their bactericidal activity. Another factor that has increased bacterial resistance is the ease of transfer of genes from two resistance against antibiotics by means of plasmids, transposons and integrons
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Antibacterianos, Infecciones urinarias, Enterobacteriaceae, Hospital SOLCA de Guayaquil, Cantón Guayaquil, Ecuador, Betalactamasas de espectro extendido