Comparación preclínica de la eficacia sobre la actividad adelgazante de dos fármacos comercializados en el Ecuador
Fecha
2020
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
La obesidad es causante de diferentes patologías y desórdenes a nivel de órganos y sistemas en el cuerpo humano. Por tal motivo, el presente trabajo de titulación comparó preclínicamente la eficacia sobre la actividad adelgazante de dos fármacos comercializados en Ecuador.
Utilizando ratones de experimentación CD-1, se formó siete grupos de ocho ratones cada uno: Control más tres grupos de los fármacos 1 y 2, en dosis de 1000, 500 y 250 mg/kg de peso; inicialmente se presentó un peso promedio de 27 ± 1.5 gramos. La dosificación fue por 60 días registrando datos de pesos corporales y consumo de balanceado y agua, determinando diferencias entre los mismos de manera bioestadística. Los datos recolectados no mostraron diferencias significativas, esta tendencia siguió hasta el final del estudio. Por lo expuesto, se estableció que los fármacos administrados en diferentes dosis, no redujeron el peso corporal de los biomodelos en el tiempo de estudio.
Obesity is the cause of different pathologies and disorders at the level of organs and systems in the human body. For this reason, the present degree work preclinical compared the efficacy on the slimming activity of two drugs marketed in Ecuador. Using CD1 experimentation mice, seven groups of eight mice each one were formed: Control plus three groups of drug 1 and 2, in doses of 1000, 500 and 250 mg / kg of weight; at the beginning, an average weight of 27 ± 1.5 grams was presented. The dosification was for 60 days recording data of body weights and consumption of balanced and water, determining differences among them in bio- statistical manner. The data collected did not show significant differences, this trend continued until the end of the study. Therefore, it was established that the drugs administered in different doses did not reduce the body weight of the bio-models at the time of study.
Obesity is the cause of different pathologies and disorders at the level of organs and systems in the human body. For this reason, the present degree work preclinical compared the efficacy on the slimming activity of two drugs marketed in Ecuador. Using CD1 experimentation mice, seven groups of eight mice each one were formed: Control plus three groups of drug 1 and 2, in doses of 1000, 500 and 250 mg / kg of weight; at the beginning, an average weight of 27 ± 1.5 grams was presented. The dosification was for 60 days recording data of body weights and consumption of balanced and water, determining differences among them in bio- statistical manner. The data collected did not show significant differences, this trend continued until the end of the study. Therefore, it was established that the drugs administered in different doses did not reduce the body weight of the bio-models at the time of study.
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SOBREPESO, INVESTIGACIÓN, ACTIVIDAD ADELGAZANTE, PESO CORPORAL