Causas de hepatitis reactiva en pacientes con signos de alarma de dengue
Fecha
2020
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Medicina
Resumen
Antecedentes: El dengue es una enfermedad viral trasmitida por artrópodos. Según la OMS/OPS a nivel mundial, en el último año se detectan alrededor de 1´914,207 casos. La enfermedad tiene un periodo de incubación de 1-7 días. La hepatitis reactiva, una de las complicaciones de la enfermedad, se presenta con más frecuencia en los pacientes hospitalizados. Objetivo: Determinar las posibles causas de hepatitis reactiva en pacientes con dengue con signos de alarma. Metodología: Es una investigación de tipo cuantitativa con diseño no experimental, de corte transversal, observacional y analítico. Resultados: Para este estudio se tomó a 230 pacientes con diagnóstico de dengue con signos de alarma, del hospital general Martin Icaza de la ciudad de Babahoyo, durante los años 2018-2020. Se demostró que, de los 230 pacientes con dengue con signos de alarma, 87 durante su estancia hospitalaria realizaron algún grado de lesión hepática, Por lo tanto, se concluye que el tropismo del virus hacia el hígado tiende a lesionar de manera leve al hepatocito. El serotipo DENV-1, que circulo con mayor frecuencia en el país, existe una relación importante con los casos registrados de hepatitis reactiva. El uso de paracetamol, de forma continua, durante toda la estancia hospitalaria del paciente, tiende a aumentar las enzimas hepáticas.
Background: Dengue is a viral disease transmitted by arthropods. According to WHO / PAHO worldwide, in the last year around 1,914,207 cases have been detected. The disease has an incubation period of 1-7 days. Reactive hepatitis, one of the complications of the disease, occurs more frequently in hospitalized patients. Objective: To determine the possible causes of reactive hepatitis in dengue patients with warning signs. Methodology: It is a quantitative research with a non-experimental, cross-sectional, observational and analytical design. Results: For this study, 230 patients with a diagnosis of dengue with alarm signs were taken from the Martin Icaza general hospital in the city of Babahoyo, during the years 2018-2020. It was shown that, of the 230 patients with dengue with warning signs, 87 during their hospital stay carried out some degree of liver injury. Therefore, it is concluded that the tropism of the virus towards the liver tends to slightly injure the hepatocyte. The DENV-1 serotype, which circulates most frequently in the country, has an important relationship with the registered cases of reactive hepatitis. The use of paracetamol, continuously, throughout the patient's hospital stay, tends to increase liver enzymes.
Background: Dengue is a viral disease transmitted by arthropods. According to WHO / PAHO worldwide, in the last year around 1,914,207 cases have been detected. The disease has an incubation period of 1-7 days. Reactive hepatitis, one of the complications of the disease, occurs more frequently in hospitalized patients. Objective: To determine the possible causes of reactive hepatitis in dengue patients with warning signs. Methodology: It is a quantitative research with a non-experimental, cross-sectional, observational and analytical design. Results: For this study, 230 patients with a diagnosis of dengue with alarm signs were taken from the Martin Icaza general hospital in the city of Babahoyo, during the years 2018-2020. It was shown that, of the 230 patients with dengue with warning signs, 87 during their hospital stay carried out some degree of liver injury. Therefore, it is concluded that the tropism of the virus towards the liver tends to slightly injure the hepatocyte. The DENV-1 serotype, which circulates most frequently in the country, has an important relationship with the registered cases of reactive hepatitis. The use of paracetamol, continuously, throughout the patient's hospital stay, tends to increase liver enzymes.
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DENGUE, HEPATITIS, EPIDEMIOLOGÍA ANALÍTICA, HOSPITAL GENERAL MARTÍN ICAZA, CANTÓN BABAHOYO, ECUADOR