Eficacia de la respuesta celular inflamatoria como marcadores de diagnóstico del cáncer de próstata
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2021
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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El Cáncer de Próstata es una neoplasia hormonodependiente, factores como: Edad, raza, genética, estimulación hormonal, enfermedades infecciosas favorecen su génesis. Nuevas investigaciones afirman que la medición de linfocitos T, es una rápida técnica para pesquisa de esta enfermedad. Por tal motivo se realizó un estudio observacional, retrospectivo, transversal de tipo correlacional. El estudio fue realizado en el Hospital Luis Vernaza desde el 1 de enero del 2019 hasta el 31 de agosto del 2020. Los resultados obtenidos demostraron una media de edad de 70 años, presencia de: Hematuria, Nicturia y retención urinaria como síntomas principales. Al tacto rectal se apreció: Superficie prostática irregular y consistencia dura. El tamaño prostático promedio fue de 2.5 cm. La relación total de Neutrófilos > 7800 cel/ml, con asociación positiva y sensibilidad del 85 % y especificidad del 55 %. Ratio Neutrófilos/Linfocitos > 3:1 con asociación positiva y sensibilidad del 81 % y especificidad del 58 %. Ratio Plaquetas/Linfocitos > 180 con asociación positiva y sensibilidad del 78 % y especificidad del 51 %. La ratio Linfocitos/Monocitos > 2.9 con asociación positiva y sensibilidad del 83 % y especificidad del 52 %. El punto de cohorte para PSA total fue de 9 ng/ml y para PSA libre fue de 0.3 ng/ml, el cual arrojó una sensibilidad del 82.01 % y especificidad del 51.1 %. La eficacia de la respuesta celular inflamatoria fue medible con prueba de Chi cuadrado obteniéndose una significación asintótica de .002 (IC del 95%); lo que indica es un adecuado marcador diagnóstico
Prostate Cancer is a hormone dependent neoplasm, factors such as: Age, race, genetics, hormonal stimulation, infectious diseases favor its genesis. New investigations affirm that the measurement of T lymphocytes is a rapid technique for the investigation of this disease. For this reason a study was carried out: Observational, retrospective, cross-sectional of correlational type. The study was carried out at the Luis Vernaza Hospital from January 1, 2019 to August 31, 2020. The results obtained showed a mean age of 70 years, presence of: Hematuria, Nocturia and urinary retention as symptoms main. The rectal examination revealed: irregular prostate surface and hard consistency. The average prostate size was 2.5 cm. The total ratio of Neutrophils> 7800 cells / ml, with a positive association and sensitivity of 85% and specificity of 55%. Neutrophil / Lymphocyte Ratio> 3: 1 with positive association and sensitivity of 81% and specificity of 58%. Platelet / Lymphocyte Ratio> 180 with positive association and sensitivity of 78% and specificity of 51%. Lymphocytes / Monocytes ratio> 2.9 with positive association and sensitivity of 83% and specificity of 52%. The cohort point for total PSA was 9 ng / ml and for free PSA it was 0.3 ng / ml, which yielded a sensitivity of 82.01% and specificity of 51.1%. The efficacy of the inflammatory cellular response was measurable with the Chi square test, obtaining an asymptotic significance of .002 (95% CI); what it indicates is an adequate diagnostic marker
Prostate Cancer is a hormone dependent neoplasm, factors such as: Age, race, genetics, hormonal stimulation, infectious diseases favor its genesis. New investigations affirm that the measurement of T lymphocytes is a rapid technique for the investigation of this disease. For this reason a study was carried out: Observational, retrospective, cross-sectional of correlational type. The study was carried out at the Luis Vernaza Hospital from January 1, 2019 to August 31, 2020. The results obtained showed a mean age of 70 years, presence of: Hematuria, Nocturia and urinary retention as symptoms main. The rectal examination revealed: irregular prostate surface and hard consistency. The average prostate size was 2.5 cm. The total ratio of Neutrophils> 7800 cells / ml, with a positive association and sensitivity of 85% and specificity of 55%. Neutrophil / Lymphocyte Ratio> 3: 1 with positive association and sensitivity of 81% and specificity of 58%. Platelet / Lymphocyte Ratio> 180 with positive association and sensitivity of 78% and specificity of 51%. Lymphocytes / Monocytes ratio> 2.9 with positive association and sensitivity of 83% and specificity of 52%. The cohort point for total PSA was 9 ng / ml and for free PSA it was 0.3 ng / ml, which yielded a sensitivity of 82.01% and specificity of 51.1%. The efficacy of the inflammatory cellular response was measurable with the Chi square test, obtaining an asymptotic significance of .002 (95% CI); what it indicates is an adequate diagnostic marker
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NEOPLASIAS DE LA PROSTATA, DIAGNOSTICO CLINICO, CELULAS INFLAMATORIAS, BIOPSIA, ESTUDIOS RETROSPECTIVOS, HOSPITAL LUIS VERNAZA, CANTON GUAYAQUIL, ECUADOR