Estudio de la sensibilidad de la ciprofloxacina frente a pseudomonas aisladas de diversas muestras biologicas
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2003
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
Se realizó un estudio prospectivo donde se analiza y se describe el comportamiento in Vitro de la ciprofloxacina frente a las diversas Pseudomonas aisladas en diversas muestras biológicas en el Laboratorio de Bacteriología-Peste del Instituto Nacional de Higiene y Medicina Tropical “ Leopoldo Izquieta Pérez”durante el período comprendido de Octubre del 2001 a Febrero del 2002 con el objeto de determinar la actividad antimicrobiana de la ciprofloxacina.
El mayor porcentaje de Pseudomonas aisladas procedía de secreciones del tracto respiratorio(68.8%), orina (14%), siendo la P. aeruginosa (90%), B. cepacia (8%), P. fluorescens(2%) las Pseumonas aisladas con más frecuencia.
Se estudió además la procedencia, grupos hectáreos con mayor susceptibilidad a infecciones y la distribución de las mismas según el producto patológico, realizándose pruebas de sensibilidad a la ciprofloxacina en relación con otros agentes antipseudomonicos sugeridos para el tratamiento de infecciones causadas por Pseudomonas.
Los resultados demuestran que la P. aeruginosa (90%) es el agente causal del mayor número de infecciones, siendo el genero masculino los más susceptibles a adquirir infecciones por Pseudomonas en edades comprendidas entre los 15 a 49 años y que se encuentran hospitalizados, presentando la ciprofloxacina mayor actividad( 90%) y efecto antimicrobiano en comparación con los otros agentes antipseudomonicos clásicos de elección, presentando una susceptibilidad de 88.8% para la P. aeruginosa y del 100% para las P. fluorescens y B.cepacea.
Se demostró además que las Pseudomonas aisladas causantes de los procesos infecciosos de las vías urinarias, hematologicos, y del tracto respiratorio eran totalmente susceptibles a la Ciprofloxacina; siendo la guía más práctica con que cuenta el médico para la elección del tratamiento inicial empírico conveniente, comprobando que es el agente terapéutico más eficaz para el tratamiento contra las infecciones provocadas por Pseudomonas lo que nos indica que es un excelente bactericida, fortaleciendo así con este estudio los esquemas teóricos de prescripción médica para el tratamiento de infecciones causadas por Pseudomonas en el hombre.
To report a prospective study that describes and analyses the in-vitro activity of ciprofloxacin against several Pseudomonas isolates from diversal biologicals samples in the Laboratory of Bacteriology-Pest from Hygiene National Institute and Tropical Medicine “ Leopoldo Izquieta Perez ” during the period between October 2001 to February 2002 with the object of determinate the antimicrobial activity of ciprofloxacin. The greatest percentages of Pseudomonas isolates were found in respiratory secretions (40%), urine(14%), P. aeruginosa (90%), B. cepacia (8%) and P. fluorescens (2%)were Pseudomonas the species most commonly isolated. Distribution of microorganism strains according to the age group’s that present most susceptibility to infections, distribution according to pathologyc samples,testing the sensibility to ciprofloxacin in relation to the others antipseudomonics agents suggest for the treatments of infections caused by Pseudomonas. The results have shown that P.aeruginosa (90%) is the agent that causes the most number of infections, and there were the men with ages between 15-49 years old were most susceptibility to get infections by Pseudomonas and there ‘re in hospitalization, showing that that ciprofloxacin get the highest activity(90%) and antimicrobial effect in relation to the others classic antipseudomonics agents, presenting a susceptibility of 88.8% against to P. aeruginosa and 100% against to P. fluorescens and B. cepacia. This study have shown that the Pseudomona isolates causes of infections process of urinary tract, hematologic and respiratory tract, were totaly susceptibility to ciprofloxacin, making the practic guide in wich the doctor could count to choose the convenient empiric initial treatment, proving that there’s the effective bactericide therapeutic agent for the treatment againts infections causes by Pseudomonas, making strong the studies of medical prescription for the treatments of infections causes by Pseudomonas in the man.
To report a prospective study that describes and analyses the in-vitro activity of ciprofloxacin against several Pseudomonas isolates from diversal biologicals samples in the Laboratory of Bacteriology-Pest from Hygiene National Institute and Tropical Medicine “ Leopoldo Izquieta Perez ” during the period between October 2001 to February 2002 with the object of determinate the antimicrobial activity of ciprofloxacin. The greatest percentages of Pseudomonas isolates were found in respiratory secretions (40%), urine(14%), P. aeruginosa (90%), B. cepacia (8%) and P. fluorescens (2%)were Pseudomonas the species most commonly isolated. Distribution of microorganism strains according to the age group’s that present most susceptibility to infections, distribution according to pathologyc samples,testing the sensibility to ciprofloxacin in relation to the others antipseudomonics agents suggest for the treatments of infections caused by Pseudomonas. The results have shown that P.aeruginosa (90%) is the agent that causes the most number of infections, and there were the men with ages between 15-49 years old were most susceptibility to get infections by Pseudomonas and there ‘re in hospitalization, showing that that ciprofloxacin get the highest activity(90%) and antimicrobial effect in relation to the others classic antipseudomonics agents, presenting a susceptibility of 88.8% against to P. aeruginosa and 100% against to P. fluorescens and B. cepacia. This study have shown that the Pseudomona isolates causes of infections process of urinary tract, hematologic and respiratory tract, were totaly susceptibility to ciprofloxacin, making the practic guide in wich the doctor could count to choose the convenient empiric initial treatment, proving that there’s the effective bactericide therapeutic agent for the treatment againts infections causes by Pseudomonas, making strong the studies of medical prescription for the treatments of infections causes by Pseudomonas in the man.
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ANTIBIÓTICOS, BACTERIOLOGÍA, CIPROFLOXACINA, INFECCIONES DEL TRACTO URINARIO - TRATAMIENTO