Correlación entre cociente proteínas/creatinina en muestra de orina y proteinuria de 24 horas para el diagnóstico precoz de preeclampsia
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2019
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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El objetivo del presente fue determinar la correlación entre el cociente proteína / creatinina en orina y proteinuria en 24 horas en preeclampticas atendidas en el hospital de la Mujer Alfredo G. Paulson. Para la validación de ambas pruebas se calcularon sensibilidad, especificidad, valores predictivos y Chi cuadrado. Se evaluaron: edad, tipo de preeclampsia, valores de proteinuria en 24 hora, y cociente proteína/ creatinina. Por el tipo de investigación es un estudio de tipo: Analítico, correlacional, retrospectivo, de corte transversal. Los resultados obtenidos demostraron un Chi cuadrado de .000 con un (IC 95%), La población de estudio fue de 123 mujeres entre 16 y 45 años, cuya mayor concentración de casos correspondió a Preeclampsia con signos de gravedad (82.1 %) y preeclampsia sin signos de gravedad con (17.9 %). El valor máximo de proteinuria en 24 h en la población de estudio fue: 4401.90 (mg/dl) y el valor mínimo de proteinuria en 24 h fue 20.76 (mg/dl). Para el cociente proteína/creatinina el valor máximo fue de 4.57 (mg/ml) y el valor mínimo 0.11 (mg/ml). La sensibilidad para proteinuria en 24 h fue del 92 % y especificidad del 98 % en relación al cociente proteína/creatinina en orina con una sensibilidad del 78 % y especificidad del 83 %.Los valores predictivos positivos fueron del (VPP = 0.96) y los negativos del (VPN = 0.43). El principal factor que altera el resultado de la prueba es la hora de recolección de la muestra para cociente proteína / creatinina por lo que se sugiere una toma matutina para mejorar el resultado
The objective of the present was to determine the correlation between the protein / creatinine ratio in urine and proteinuria in 24 hours in preeclamptic patients treated at the Alfredo G Paulson Women's Hospital. For the validation of both tests sensitivity, specificity, predictive values and Chi square were calculated. The following were evaluated: age, type of preeclampsia, proteinuria values in 24 hours, and protein / creatinine ratio. For the type of research is a study of type: Analytical, correlational, retrospective, cross-sectional. The results obtained showed a Chi square of .000 (95% CI). The study population was 123 women between 16 and 45 years old. The highest concentration of cases corresponded to Preeclampsia with signs of severity (82.1%) and preeclampsia without signs of severity (17.9%). The maximum value of proteinuria in 24 h in the study population was: 4401.90 (mg / dl) and the minimum value of proteinuria in 24 h was 20.76 (mg / dl). For the protein / creatinine ratio the maximum value was 4.57 (mg /ml) and the minimum value 0.11 (mg /ml). The sensitivity for proteinuria in 24 h was 92% and specificity of 98% in relation to the ratio protein / creatinine in urine with a sensitivity of 78% and specificity of 83%. The positive predictive values were (PPV = 0.96) and the negative values (VPN = 0.43). The main factor that alters the result of the test is the time of collection of the sample, so a morning shot is suggested to improve the result.
The objective of the present was to determine the correlation between the protein / creatinine ratio in urine and proteinuria in 24 hours in preeclamptic patients treated at the Alfredo G Paulson Women's Hospital. For the validation of both tests sensitivity, specificity, predictive values and Chi square were calculated. The following were evaluated: age, type of preeclampsia, proteinuria values in 24 hours, and protein / creatinine ratio. For the type of research is a study of type: Analytical, correlational, retrospective, cross-sectional. The results obtained showed a Chi square of .000 (95% CI). The study population was 123 women between 16 and 45 years old. The highest concentration of cases corresponded to Preeclampsia with signs of severity (82.1%) and preeclampsia without signs of severity (17.9%). The maximum value of proteinuria in 24 h in the study population was: 4401.90 (mg / dl) and the minimum value of proteinuria in 24 h was 20.76 (mg / dl). For the protein / creatinine ratio the maximum value was 4.57 (mg /ml) and the minimum value 0.11 (mg /ml). The sensitivity for proteinuria in 24 h was 92% and specificity of 98% in relation to the ratio protein / creatinine in urine with a sensitivity of 78% and specificity of 83%. The positive predictive values were (PPV = 0.96) and the negative values (VPN = 0.43). The main factor that alters the result of the test is the time of collection of the sample, so a morning shot is suggested to improve the result.
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Preeclampsia, Proteinuria, Creatinina, Proteina, Orina, Epidemiología analítica, Estudios retrospectivos, Hospital de la Mujer Alfredo G. Paulson, Cantón Guayaquil, Ecuador