Factores de riesgo asociados a litiasis renal en hiperparatiroidismo primario
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2019
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Antecedentes: La frecuencia de nefrolitiasis en pacientes con
Hiperparatiroidismo primario es variable dependiente del ámbito geográfico y los
factores de riesgo son aún poco claros.
Objetivo: Identificar los factores que incrementan el riesgo de nefrolitiasis entre
la población con hiperparatiroidismo primario.
Metodología: Se realizó un estudio transversal en el que se incluyeron de manera
no aleatoria 22 pacientes con nefrolitiasis y 70 sin esta patología atendidos entre el
1 de enero de 2015 a 31 diciembre de 2018 en el hospital Teodoro Maldonado
Carbo.
Resultado: La frecuencia de litiasis renal en pacientes con HPTP fue del 24%.
Los adultos jóvenes fueron más numerosos entre pacientes con litiasis (40,9% vs
10%: P 0,001; OR 2,889: IC95% 1,070 – 7,797). Los pacientes que tenían litiasis
eran mayormente varones (45,5% vs 17,1%: P 0,007; OR 4,027; IC95% 1,417 –
11,445). La obesidad fue mayor entre pacientes con litiasis (50% vs 25,7%; P
0,032). La insuficiencia renal pareció proteger contra el desarrollo de litiasis
(9,1% vs 30%: P 0,048; OR 2,33; IC95% 0,050 – 1,089). El uso de tratamiento
nutricional con vitamina D activa, pareció proteger del desarrollo de litiasis renal
(22,7% vs. 52,9%: P 0,013; OR 0,262; IC95% 0,87 – 0,790). Los pacientes
adultos jóvenes tuvieron un mayor riesgo de litiasis renal (40,9% vs. 10%: P
0,001; OR 6,231; IC95% 1,965 – 19,76). – 1,681)
Conclusión: La frecuencia de litiasis renal entre pacientes con HPTP es alta y el
desarrollo de litiasis renal en esta población es multifactorial
Background: The prevalence of nephrolithiasis in patients with primary hyperparathyroidism is variable depending on the geographic scope and the risk factors are still unclear. Objective: To identify the factors that increase the risk of nephrolithiasis among the population with primary hyperparathyroidism. Methodology: A cross-sectional study was carried out in which 22 patients with nephrolithiasis and 70 without this pathology treated between January 1, 2015 and December 31, 2018 were included in the Teodoro Maldonado Carbo hospital. Result: The prevalence of renal lithiasis in patients with PHPT was 24%. Young adults were more numerous among patients with lithiasis (40.9% vs. 10%: P 0.001; OR 2,889: 95% CI 1,070 - 7,797). The patients who had lithiasis were mostly male (45.5% vs. 17.1%: P 0.007; OR 4.027; 95% CI 1.417 - 11.445). Obesity was higher among patients with lithiasis (50% vs. 25.7%; P 0.032). Renal insufficiency seemed to protect against the development of lithiasis (9.1% vs. 30%: P 0.048; OR 2.33; 95% CI 0.050 - 1.089). The use of nutritional treatment with active vitamin D seemed to protect against the development of renal lithiasis (22.7% vs. 52.9%: P 0.013; OR 0.262; 95% CI 0.87 - 0.790). Young adult patients had an increased risk of renal lithiasis (40.9% vs. 10%: P 0.001; OR 6.231; 95% CI 1.965-19.76). - 1,681) Conclusion: The prevalence of renal lithiasis among patients with PHPT is high and the development of renal lithiasis in this population is multifactorial.
Background: The prevalence of nephrolithiasis in patients with primary hyperparathyroidism is variable depending on the geographic scope and the risk factors are still unclear. Objective: To identify the factors that increase the risk of nephrolithiasis among the population with primary hyperparathyroidism. Methodology: A cross-sectional study was carried out in which 22 patients with nephrolithiasis and 70 without this pathology treated between January 1, 2015 and December 31, 2018 were included in the Teodoro Maldonado Carbo hospital. Result: The prevalence of renal lithiasis in patients with PHPT was 24%. Young adults were more numerous among patients with lithiasis (40.9% vs. 10%: P 0.001; OR 2,889: 95% CI 1,070 - 7,797). The patients who had lithiasis were mostly male (45.5% vs. 17.1%: P 0.007; OR 4.027; 95% CI 1.417 - 11.445). Obesity was higher among patients with lithiasis (50% vs. 25.7%; P 0.032). Renal insufficiency seemed to protect against the development of lithiasis (9.1% vs. 30%: P 0.048; OR 2.33; 95% CI 0.050 - 1.089). The use of nutritional treatment with active vitamin D seemed to protect against the development of renal lithiasis (22.7% vs. 52.9%: P 0.013; OR 0.262; 95% CI 0.87 - 0.790). Young adult patients had an increased risk of renal lithiasis (40.9% vs. 10%: P 0.001; OR 6.231; 95% CI 1.965-19.76). - 1,681) Conclusion: The prevalence of renal lithiasis among patients with PHPT is high and the development of renal lithiasis in this population is multifactorial.
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Hiperparatiroidismo, Litiasis renal, Epidemiología, Factores de riesgo, Hospital de Especialidades Dr. Teodoro Maldonado Carbo, Cantón Guayaquil, Ecuador