Aclaramiento de creatinina en orina de 2 horas vs 24 horas para estimar el filtrado glomerular, Hospital Luis Vernaza
No hay miniatura disponible
Fecha
2016
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Objetivo: Evaluar si el aclaramiento de creatinina en orina de 2 horas es tan eficaz como el de 24 horas para estimar la tasa de filtrado glomerular. Materiales y Métodos: estudio observacional, descriptivo, prospectivo, no experimental. La población en estudio correspondió a 668 pacientes y la muestra de 118 pacientes, en un periodo de 1 año; desde abril de 2014 a mayo de 2015 en el Hospital Luis Vernaza. El aclaramiento de creatinina se calculó con la fórmula (UxV/P), U corresponde a concentración de creatinina en orina (en 2 y 24 horas), V el volumen de orina (en 2 y 24 horas) y P creatinina sérica. Se diagnosticó insuficiencia renal con valores de creatinina sérica iguales o mayores a 1.3 mg/dl. Resultados: Se incluyeron 118 pacientes, el promedio de edad fue de 59 años, la relación entre los sexos fue: masculino con 55% y femenino 45 % de los casos. El valor promedio de creatinina sérica fue 2,89 mg/dl; el volumen de orina promedio en 2 horas fue de 173 ml el 24 horas fue 2158 ml. La media del aclaramiento de creatinina en orina de 2 horas fue 39,76 ml/m, la media en aclaramiento de 24 horas fue 40,08 ml/m. Se asignó a los pacientes de acuerdo al filtrado glomerular el 36% se encontraban en estadio 5. Entre los antecedentes patológicos encontramos a la hipertensión arterial con 83 (45,1%), seguida de diabetes tipo 2 con 69 casos (37,5%). Conclusiones: En la práctica médica habitual se considera al aclaramiento de creatinina en orina de 24 horas el método de elección para estimar el filtrado glomerular, con el inconveniente en el tiempo de recolección de orina sobre todo en edades extremas. Por lo que concluimos que no encontramos diferencias estadísticamente significativas en los resultados obtenidos en el aclaramiento de creatinina en orina de 2 horas versus 24 horas, por lo que recomendamos utilizar esta prueba diagnóstica con reducción en tiempo de recolección de orina de 24 horas a solamente 2 horas.
Objective: To evaluate if the urine creatinine clearance of 2 hours is as effective as 24 hours to estimate the glomerular filtration rate. Materials and Methods: Observational, descriptive, prospective, non-experimental study. The study population corresponded to 668 patients and the sample of 118 patients over a period of one year; from April 2014 to May 2015 in the Luis Vernaza Hospital. Creatinine clearance was calculated using the formula (UxV / P), U corresponds to urine creatinine concentration (at 2 and 24 hours), V the volume of urine (at 2 and 24 hours) and P serum creatinine. Renal failure was diagnosed with serum creatinine values equal to or greater than 1.3 mg / dl. Results: 118 patients were included, the average age was 59 years, and the relationship between the sexes was: 55% male and 45% female cases. The average value of serum creatinine was 2.89 mg / dl; the average volume of urine in 2 hours was 173 ml 24 hours was 2158 ml. The mean urine creatinine clearance in 2 hours was 39.76 ml / m, the average clearance of 24 hours was 40.08 ml / m. patients according to GFR was assigned 36% were in stage 5. Among the medical history of hypertension found in 83 (45.1%), followed by type 2 diabetes with 69 cases (37.5%). Conclusions: In normal medical practice is considered to creatinine clearance in 24-hour urine the method of choice for estimating glomerular filtration rate, with the disadvantage at the time of urine collection especially in extreme ages. So we conclude that no statistically significant differences in the results of creatinine clearance urine 2 hours versus 24 hours, so we recommend using this diagnostic test with reduced time collecting 24-hour urine only 2 hours.
Objective: To evaluate if the urine creatinine clearance of 2 hours is as effective as 24 hours to estimate the glomerular filtration rate. Materials and Methods: Observational, descriptive, prospective, non-experimental study. The study population corresponded to 668 patients and the sample of 118 patients over a period of one year; from April 2014 to May 2015 in the Luis Vernaza Hospital. Creatinine clearance was calculated using the formula (UxV / P), U corresponds to urine creatinine concentration (at 2 and 24 hours), V the volume of urine (at 2 and 24 hours) and P serum creatinine. Renal failure was diagnosed with serum creatinine values equal to or greater than 1.3 mg / dl. Results: 118 patients were included, the average age was 59 years, and the relationship between the sexes was: 55% male and 45% female cases. The average value of serum creatinine was 2.89 mg / dl; the average volume of urine in 2 hours was 173 ml 24 hours was 2158 ml. The mean urine creatinine clearance in 2 hours was 39.76 ml / m, the average clearance of 24 hours was 40.08 ml / m. patients according to GFR was assigned 36% were in stage 5. Among the medical history of hypertension found in 83 (45.1%), followed by type 2 diabetes with 69 cases (37.5%). Conclusions: In normal medical practice is considered to creatinine clearance in 24-hour urine the method of choice for estimating glomerular filtration rate, with the disadvantage at the time of urine collection especially in extreme ages. So we conclude that no statistically significant differences in the results of creatinine clearance urine 2 hours versus 24 hours, so we recommend using this diagnostic test with reduced time collecting 24-hour urine only 2 hours.
Descripción
PDF
Palabras clave
Aclaramiento de creatinina, Filtración glomerular, Insuficiencia renal crónica, Epidemiología descriptiva, Estudios retrospectivos, Hospital Luis Vernaza, Cantón Guayaquil, Ecuador