Eficacia del Paracetamol como terapéutica posquirúrgica en la cicatrización de los tejidos
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2014-07
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Universidad de Guayaquil. Facultad Piloto de Odontología
Resumen
Uno de factores más relevantes en cirugía oral es la cicatrización de
los tejidos y el tratamiento del dolor posquirúrgico. En cirugía oral
menor como cualquier otra cirugía se manifiesta en el organismo
como una injuria desencadenando todos los procesos necesarios
para que se produzca la reparación de los tejidos, parte de estos
acontecimientos es el proceso inflamatorio de gran importancia ya
que aquí tienen participación activa las plaquetas, la quimiotaxis de
neutrófilos y macrófagos los cuales contribuyen enormemente en la
formación de factores de crecimientos muy necesarios en la
cicatrización de los tejidos. Para el tratamiento de dolor se suele
prescribir con mucha regularidad Antiinflamatorios no esteroideos,
los cuales tienen como finalidad inhibir las Ciclooxigenasas (COX-1,
COX-2) que son precursores de las prostaglandinas responsables
del proceso inflamatorio, pero así mismo produce reacciones
farmacológicas dañinas para los pacientes ya que estas no solo
tienen papel importante en la inflamación sino también son parte
constitutiva de ciertos órganos y tejidos como en la mucosa
estomacal, riñones, próstata y útero, produciendo gastropatías por
consumo prolongado de Aines, y en ocasiones nefropatías. Los
Aines al inhibir el proceso inflamatorio tienen efecto notable
retardando la cicatrización de los tejidos. El paracetamol es un
analgésico antipirético clasificado en el grupo de los Aines pero sin
tener efecto antinflamatorio ya que no inhibe las COX-1 y COX-2,
sino a su isoforma COX-3 y la inhibiendo en el sistema nervioso
central y no a nivel periférico, de esta forma no altera el proceso de
cicatrización y regeneración tisular.
One of most important factors in oral surgery is the scar tissue and the treatment of postsurgical pain. In oral surgery less as any other surgery is manifested in the body as an insult triggering all the processes needed for tissue repair, part of these events is the inflammatory process of great importance because here have active participation the platelets, chemotaxis of neutrophils and macrophages which contribute greatly to the formation of growth factors very necessary in the scarring of the tissues. For the treatment of pain is usually prescribed with much regularity nonsteroidal anti-inflammatory drugs, which have as purpose inhibit Cyclooxygenases (COX-1, COX-2) are precursors of prostaglandins responsible for the inflammatory process, but that same produces harmful drug reactions for patients because they not only have important role in the inflammation but also are a constituent part of certain organs and tissues as in the mucous membranes of the stomach, kidneys, prostate, and uterus, stomach diseases by producing long-term use of NSAIDS, and sometimes nephropathies. The NSAIDS to inhibit the inflammatory process have notable effect by slowing the healing of the tissues. The acetaminophen is an analgesic antipyretic classified in the group of NSAIDS but without having already anti-inflammatory effect that does not inhibit the COX1 and COX-2 , but its COX-3 isoform and the inhibiting in the central nervous system and not at the peripheral level, in this way does not alter the process of healing and tissue regeneration.
One of most important factors in oral surgery is the scar tissue and the treatment of postsurgical pain. In oral surgery less as any other surgery is manifested in the body as an insult triggering all the processes needed for tissue repair, part of these events is the inflammatory process of great importance because here have active participation the platelets, chemotaxis of neutrophils and macrophages which contribute greatly to the formation of growth factors very necessary in the scarring of the tissues. For the treatment of pain is usually prescribed with much regularity nonsteroidal anti-inflammatory drugs, which have as purpose inhibit Cyclooxygenases (COX-1, COX-2) are precursors of prostaglandins responsible for the inflammatory process, but that same produces harmful drug reactions for patients because they not only have important role in the inflammation but also are a constituent part of certain organs and tissues as in the mucous membranes of the stomach, kidneys, prostate, and uterus, stomach diseases by producing long-term use of NSAIDS, and sometimes nephropathies. The NSAIDS to inhibit the inflammatory process have notable effect by slowing the healing of the tissues. The acetaminophen is an analgesic antipyretic classified in the group of NSAIDS but without having already anti-inflammatory effect that does not inhibit the COX1 and COX-2 , but its COX-3 isoform and the inhibiting in the central nervous system and not at the peripheral level, in this way does not alter the process of healing and tissue regeneration.
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Palabras clave
PARACETAMOL, CLINICA MEDICA, CICATRIZACION DE HERIDAS
Citación
Alcívar Manzo, Mauro Alfredo (2014) : Eficacia del Paracetamol como terapéutica posquirúrgica en la cicatrización de los tejidos