Eficacia y seguridad de esteroides versus diuréticos en el tratamiento de la displasia broncopulmonar
Fecha
2021
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
La displasia broncopulmonar es una condición médica muy prevalente en los neonatos prematuros, especialmente en los de muy bajo peso, teniendo mayor incidencia en los de menor edad estacional. Esto se da por el bajo desarrollo pulmonar de estos pacientes, lo cual los predisponen a desarrollar displasia broncopulmonar por mecanismos de inflamación al tratar de adaptarse al nuevo medio, el extrauterino. Así mismo otros agentes lesivos pueden desencadenar inflamación en los pulmones, esto desencadena mecanismos de lesión, entre los cuales destacan la asodilatación que aumenta la presión hidrostática que a su vez aumenta la permeabilidad provocando la aparición de exudado desde los vasos sanguíneos que finalmente causa edema, afectando la función normal de los pulmones; otro mecanismo de inflamación que destaca es la biosíntesis de prostaglandinas y la fibrosis del tejido lesionado. Estos 2 mecanismos de inflamación tienen una relación intrínseca con la fisiopatología de la displasia broncopulmonar y para tratar esta indicado el uso de esteroides y diuréticos, siendo muy importante la determinación de la efectividad del tratamiento de estos 2 fármacos y cuál es la mejor opción de tratamiento farmacológico.
Bronchopulmonary dysplasia is a very prevalent medical condition in premature neonates, especially in those of very low weight, having a higher incidence in those with a lower gestational age. This is due to the low lung development of these patients, which predisposes them to develop bronchopulmonary dysplasia due to inflammation mechanisms when trying to adapt to the new environment, the extrauterine. Likewise, other damaging agents can trigger inflammation in the lungs, this triggers injury mechanisms, among which vasodilation that increases hydrostatic pressure stands out, which in turn increases permeability, causing the appearance of exudate from the blood vessels that finally causes edema. affecting the normal function of the lungs; Another mechanism of inflammation that stands out is prostaglandin biosynthesis and fibrosis of the injured tissue. These 2 mechanisms of inflammation have an intrinsic relationship with the pathophysiology of bronchopulmonary dysplasia and the use of steroids and diuretics is indicated to treat, being very important to determine the effectiveness of the treatment of these 2 drugs and which is the best treatment option pharmacological.
Bronchopulmonary dysplasia is a very prevalent medical condition in premature neonates, especially in those of very low weight, having a higher incidence in those with a lower gestational age. This is due to the low lung development of these patients, which predisposes them to develop bronchopulmonary dysplasia due to inflammation mechanisms when trying to adapt to the new environment, the extrauterine. Likewise, other damaging agents can trigger inflammation in the lungs, this triggers injury mechanisms, among which vasodilation that increases hydrostatic pressure stands out, which in turn increases permeability, causing the appearance of exudate from the blood vessels that finally causes edema. affecting the normal function of the lungs; Another mechanism of inflammation that stands out is prostaglandin biosynthesis and fibrosis of the injured tissue. These 2 mechanisms of inflammation have an intrinsic relationship with the pathophysiology of bronchopulmonary dysplasia and the use of steroids and diuretics is indicated to treat, being very important to determine the effectiveness of the treatment of these 2 drugs and which is the best treatment option pharmacological.
Descripción
PDF
Palabras clave
DISPLASIA BRONCOPULMONAR, DIURETICOS, ESTEROIDES, RECIEN NACIDO DE MUY BAJO PESO, PEDIATRIA, HOSPITAL DE NIÑOS DR. ROBERTO GILBERT ELIZALDE, CANTON GUAYAQUIL, ECUADOR