Localización del cáncer de colon como factor pronóstico e impacto en la respuesta al tratamiento quimioterapéutico
Fecha
2021
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
La distinción entre el cáncer de colon del lado derecho y del lado izquierdo ha recibido
recientemente una atención considerable debido a las diferencias con respecto a las mutaciones
genéticas subyacentes. Existe un debate en curso si la ubicación del tumor en el lado derecho
versus el lado izquierdo en sí representa un factor pronóstico independiente. Objetivo:
Analizar la localización de cáncer de colon como factor pronóstico e impacto en la respuesta
al tratamiento quimioterapéutico. Metodología: Estudio observacional, retrospectivo,
transversal y analítico con enfoque cuantitativo, que se desarrollará en pacientes con cáncer de
colon del hospital de especialidades Dr. Abel Gilbert Pontón en el periodo 2017-2020.
Resultados: Se encontró que el 59,2% de los pacientes son del sexo femenino, la edad
promedio al diagnóstico fue de 54 años, además se encontró que hubo mayor incidencia de
cáncer de colon izquierdo y el 44,7% de los pacientes fueron diagnosticados en estadios más
avanzados. La regresión de Mantel-Cox demostró que no hubo asociación entre la localización
del cáncer de colon y la sobrevida global en el periodo de seguimiento Conclusión: No se
encontró asociación entre las distintas variables analizadas y lateralidad del cáncer de colon,
sin embargo, el presente trabajo ofrece datos de mucha relevancia para continuar con futuras
investigaciones.
Palabras clave: quimioterapia adyuvante; cáncer de colon; cáncer de colon del lado
izquierdo; ubicación, cáncer de colon del lado derecho, pronóstico
The distinction between right-side and left-sided colon cancer has recently received considerable attention due to differences from underlying genetic mutations. There is an ongoing debate whether the location of the tumor on the right side versus the left side itself represents an independent prognostic factor. Objective: To analyze the location of colon cancer as a prognostic factor and impact on the response to chemotherapeutic treatment. Methodology: Observational, retrospective, cross-sectional and analytical study with a quantitative approach, to be carried out in patients with colon cancer at the Dr. Abel Gilbert Pontón specialty hospital in the period 2017-2020. Results: It was found that 59,2% of the patients were female, the average age at diagnosis was 54 years, it was also found that there was a higher incidence of left colon cancer and 44.7% of the patients were diagnosed in more advanced stages. The Mantel-Cox regression showed that there was no association between the location of the colon cancer and the overall survival in the follow-up period. Conclusion: No association was found between the different variables analyzed and the laterality of the colon cancer, this investigation offers highly relevant data to continue with future research. Key words: adjuvant chemotherapy; colon cancer; colon cancer on the left side; location, right side colon cancer, prognosis
The distinction between right-side and left-sided colon cancer has recently received considerable attention due to differences from underlying genetic mutations. There is an ongoing debate whether the location of the tumor on the right side versus the left side itself represents an independent prognostic factor. Objective: To analyze the location of colon cancer as a prognostic factor and impact on the response to chemotherapeutic treatment. Methodology: Observational, retrospective, cross-sectional and analytical study with a quantitative approach, to be carried out in patients with colon cancer at the Dr. Abel Gilbert Pontón specialty hospital in the period 2017-2020. Results: It was found that 59,2% of the patients were female, the average age at diagnosis was 54 years, it was also found that there was a higher incidence of left colon cancer and 44.7% of the patients were diagnosed in more advanced stages. The Mantel-Cox regression showed that there was no association between the location of the colon cancer and the overall survival in the follow-up period. Conclusion: No association was found between the different variables analyzed and the laterality of the colon cancer, this investigation offers highly relevant data to continue with future research. Key words: adjuvant chemotherapy; colon cancer; colon cancer on the left side; location, right side colon cancer, prognosis
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NEOPLASIAS DEL COLON, PROSNOSTICO, QUIMIOTERAPIA, NEOPLASIAS POR LOCACION, ESTUDIOS RETROSPECTIVOS, EPIDEMIOLOGIA ANALITICA, HOSPITAL DE ESPECIALIDADES GUAYAQUIL DR. ABEL GILBERT PONTON, CANTON GUAYAQUIL, ECUADOR