Análisis bibliográfico del efecto inhibidor de la enzima Alfa-glucosidasa en extractos vegetales
Fecha
2021
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
Tomando como punto de partida la preocupante prevalencia de la diabetes mellitus a nivel nacional y mundial, este estudio bibliográfico reunió información de importantes bases de datos científicas, colecciones bibliográficas y editoriales, sobre potenciales alternativas para el tratamiento de esta enfermedad. Se ha logrado identificar en diversos estudios in vivo e in vitro los principales grupos de metabolitos presentes en los extractos de diversas especies vegetales cuyo efecto inhibidor de la enzima α-glucosidasa dotan a estas especies de un efecto antidiabético. Entre las cuales se apreciaron especies nativas de Ecuador como la Annona cherimola Mill., Croton ferrugineus, Croton thurifer, debiéndose principalmente a su alto contenido de alcaloides, flavonoides, terpenos y otras moléculas que inhiben esta enzima de forma aislada. También se observó que en conjunto muestran una sinergia capaz de elevar su potencial inhibidor incluso en concentraciones extremadamente bajas.
Taking as a starting point the worrying prevalence of diabetes mellitus at national and world level, this bibliographic study gathered information from mayor scientific databases, bibliographic and editorial collections, on potential alternatives for the treatment of this disease. Several plant species with inhibitory effect over the enzyme α-glucosidase were identified in in vitro and in vivo studies. Among them were native species of Ecuador such as Annona cherimola Mill., Croton ferrugineus, Croton thurifer, mainly due to their high content of alkaloids, flavonoids, terpenes, and other molecules that inhibit this enzyme in isolation. It was also observed that together they show a synergy capable of raising their inhibitory potential even at extremely low concentrations.
Taking as a starting point the worrying prevalence of diabetes mellitus at national and world level, this bibliographic study gathered information from mayor scientific databases, bibliographic and editorial collections, on potential alternatives for the treatment of this disease. Several plant species with inhibitory effect over the enzyme α-glucosidase were identified in in vitro and in vivo studies. Among them were native species of Ecuador such as Annona cherimola Mill., Croton ferrugineus, Croton thurifer, mainly due to their high content of alkaloids, flavonoids, terpenes, and other molecules that inhibit this enzyme in isolation. It was also observed that together they show a synergy capable of raising their inhibitory potential even at extremely low concentrations.
Descripción
Pdf
Palabras clave
DIABETES MELLITUS, Α-GLUCOSIDASA, INHIBIDORES, ESPECIE VEGETALES