Relación neutrófilos/linfocitos como factor pronóstico en progresión de cáncer de mama no metastásico independiente de receptores hormonales
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2021
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
El cánce de mama es el cáncer más frecuente en la mujer española, supone un 29% de todos los cánceres. En España en 2015 se diagnosticaron 27.747 cánceresde mama. Se calcula que de 1 a 8 mujeres españolas tendrá un cáncer de mama en algún momento de su vida. La edad de máxima incidencia está por encima de los 50 años, pero aproximadamente un 10% se diagnostica en mujeres menores de 40 años. Los factores de riesgo: mayor edad, exposición a estrógenos endógenos y exógenos, nuliparidad, obesidad, antecedentes familiares, consumo de tabaco y alcohol . (SEOM, 2017). Objetivo: Corroborar la relación neutrófilos/linfocitos como factor pronóstico en progresión de cáncer de mama no metastásico de acuerdo a los subtipos de receptores hormonales. Metoldología: Estudio observacional no experimental, retrospectivo, transversal, correlacional, analítico realizado en el Hospital Abel Gilbert Pontón en la ciudad de Guayaquil, Ecuador. Se tomó de pacientes de consulta externa con diagnóstico de cáncer de mamacon estadificaciónI - III, tratadas entre los años 2017 y 2020, con receptores hormonales positivos, HER2 positivo y triples negativos; se excluyó pacientes en etapa IV (metastásico) al momento del diagnóstico. Resultado: De los 205 pacientes 100 presentaron el INL< 1,5; 27 entre 1,5 - 3 y 78 > 3, que corresponde al 38%; guardando relación con los pacientes que progresaron independiente de los receptores hormonales; el grupo con recuento de INL > 3, motivo de la presente investigación, lo conformaron 78 pacientes, de los cuales progresaron 75, correspondiente al 96,.2% y tenían INL >3, Chi 2 .000, R de Pearson .000. Conclusión: Por el análisis realizado se concluye que los 75 pacientes que progresaron comprueban la hipótesis planteada en el presente estudio de investigación, puesto que se demostró que la progresión de la enfermedad guarda relación con el índice de neutrófilos /linfocitos >3 en el cáncer de mama no metastásico independiente de los receptores hormonales. Palabras claves: cáncer, mamam linfocitos, neutrófilos
Breast cancer is the most common cancer in Spanish women, accounting for 29% of all cancers. In Spain in 2015, 27,747 breast cancers were diagnosed. It is estimated that between 1 and 8 Spanish women will have breast cancer at some point in their lives. The age of maximum incidence is over 50 years, but approximately 10% are diagnosed in women under 40 years of age. Risk factors: older age, exposure to endogenous and exogenous estrogens, nulliparity, obesity, family history, tobacco and alcohol consumption. (SEOM, 2017). Objective: To corroborate the neutrophil/lymphocyte ratio as a prognostic factor in non-metastatic breast cancer progression according to hormone receptor subtypes. Methodology: Non-experimental, retrospective, cross-sectional, correlational, analytical, observational study conducted at the Abel Gilbert Pontón Hospital in the city of Guayaquil, Ecuador. It was taken from outpatients diagnosed with stage I - III breast cancer, treated between 2017 and 2020, with positive hormone receptors, HER2 positive and triple negative; patients in stage IV (metastatic) at the time of diagnosis were excluded. Result: Of the 205 patients, 100 had INL < 1.5; 27 between 1.5 - 3 and 78 > 3, which corresponds to 38%; being related to patients who progressed independent of hormone receptors; the group with INL count > 3, reason for the present investigation, was made up of 78 patients, of whom 75 progressed, corresponding to 96.2% and had INL >3, Chi 2 .000, Pearson's R .000. Conclusion: Based on the analysis carried out, it is concluded that the 75 patients who progressed confirm the hypothesis proposed in this research study, since it was shown that the progression of the disease is related to the neutrophil/lymphocyte ratio >3 in breast cancer. Hormone receptor-independent non-metastatic breast. Keywords: cancer, breast lymphocytes, neutrophils
Breast cancer is the most common cancer in Spanish women, accounting for 29% of all cancers. In Spain in 2015, 27,747 breast cancers were diagnosed. It is estimated that between 1 and 8 Spanish women will have breast cancer at some point in their lives. The age of maximum incidence is over 50 years, but approximately 10% are diagnosed in women under 40 years of age. Risk factors: older age, exposure to endogenous and exogenous estrogens, nulliparity, obesity, family history, tobacco and alcohol consumption. (SEOM, 2017). Objective: To corroborate the neutrophil/lymphocyte ratio as a prognostic factor in non-metastatic breast cancer progression according to hormone receptor subtypes. Methodology: Non-experimental, retrospective, cross-sectional, correlational, analytical, observational study conducted at the Abel Gilbert Pontón Hospital in the city of Guayaquil, Ecuador. It was taken from outpatients diagnosed with stage I - III breast cancer, treated between 2017 and 2020, with positive hormone receptors, HER2 positive and triple negative; patients in stage IV (metastatic) at the time of diagnosis were excluded. Result: Of the 205 patients, 100 had INL < 1.5; 27 between 1.5 - 3 and 78 > 3, which corresponds to 38%; being related to patients who progressed independent of hormone receptors; the group with INL count > 3, reason for the present investigation, was made up of 78 patients, of whom 75 progressed, corresponding to 96.2% and had INL >3, Chi 2 .000, Pearson's R .000. Conclusion: Based on the analysis carried out, it is concluded that the 75 patients who progressed confirm the hypothesis proposed in this research study, since it was shown that the progression of the disease is related to the neutrophil/lymphocyte ratio >3 in breast cancer. Hormone receptor-independent non-metastatic breast. Keywords: cancer, breast lymphocytes, neutrophils
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NEOPLASIAS DE LA MAMA, LINFOCITOS, NEUTROFILOS, EPIDEMIOLOGIA DESCRIPTIVA, ESTUDIO OBSERVACIONAL, ESTUDIOS RETROSPECTIVOS, HOSPITAL DE ESPECIALIDADES GUAYAQUIL DR. ABEL GILBERT PONTON, CANTON GUAYAQUIL, ECUADOR