Utilidad del índice Homa- IR en la asociación de resistencia insulínica y psoriasis de acuerdo a su severidad
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2021
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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INTRODUCCIÓN: La psoriasis es una enfermedad inflamatoria, crónica, genética, mediada inmunológicamente. Se manifiesta en la piel con lesiones eritemato-escamosas, afecta alrededor de 140 millones de personas en el mundo. Dado su carácter inflamatorio, los afectados tienen mayor riesgo de desarrollar insulinorresistencia. El índice (HOMA) Homeostatic Model Assessment Insulin Resistance constituye un método simple que provee índices de insulinorresistencia con sólo la determinación de concentraciones basales de glucosa e insulina plasmáticas. OBJETIVO: Determinar la asociación de resistencia insulínica y psoriasis de acuerdo a su severidad en pacientes que acuden al Hospital Teodoro Maldonado Carbo en el período marzo 2020 a septiembre 2020. MATERIALES Y MÉTODOS: Se realizó un estudio transversal, de tipo exploratorio, descriptivo y correlacional en el área de Dermatología en pacientes con psoriasis a quienes se les midió el índice HOMA –IR. RESULTADOS: Se registró una correlación estadísticamente significativa entre el índice HOMA-IR y las variables peso, perímetro abdominal, e IMC reportando un valores de p=0,0003; 0,006 y 0,00001 respectivamente. Mientras que para la variable severidad de la psoriasis de acuerdo a la escala PASI, la correlación resultó no ser estadísticamente significativa (p=0,70). CONCLUSIÓNES: Los pacientes con psoriasis y aumento de peso, perímetro abdominal e IMC presentan mayor prevalencia para el desarrollo de resistencia a la insulina, el uso del índice HOMA-IR representa una técnica útil para la evaluación y seguimiento de estos pacientes. Sin embargo la severidad de la psoriasis no resultó ser un indicador de resistencia insulínica en este estudio, posiblemente se requiera un mayor tamaño muestral.
PALABRAS CLAVES: Psoriasis, Resistencia Insulínica, HOMA-IR
INTRODUCTION: Psoriasis is an inflammatory, chronic, genetic, immunologically mediated disease. It manifests itself on the skin with erythematous-squamous lesions, affecting around 140 million people in the world. Given its inflammatory nature, those affected are at greater risk of developing insulin resistance. The Homeostatic Model Assessment Insulin Resistance Index (HOMA) is a simple method that provides insulin resistance indices with only the determination of basal plasma glucose and insulin concentrations. OBJECTIVE: To determine the association of insulin resistance and psoriasis according to its severity in patients attending the Teodoro Maldonado Carbo Hospital in the period March 2020 to September 2020. MATERIALS AND METHODS: A cross-sectional, exploratory, descriptive and correlational study was carried out in the area of Dermatology in patients with psoriasis who had the HOMA –IR index measured. RESULTS: A statistically significant correlation was recorded between the HOMA-IR index and the variables weight, abdominal circumference, and (BMI) body mass index, reporting p values = 0,0003; 0,006 y 0,00001 respectively, while for the variable severity according to PASI, the correlation was not statistically significant (p = 0.70). CONCLUSION: Patients with psoriasis and increased weight, abdominal circumference and BMI have a higher prevalence for the development of insulin resistance, the use of the HOMA-IR index represents a useful technique for the evaluation and follow-up of these patients. However, the severity of psoriasis was not an indicator of insulin resistance in this study, possibly a larger sample size is required. KEY WORDS: Psoriasis, Insulin Resistance, HOMA-IR
INTRODUCTION: Psoriasis is an inflammatory, chronic, genetic, immunologically mediated disease. It manifests itself on the skin with erythematous-squamous lesions, affecting around 140 million people in the world. Given its inflammatory nature, those affected are at greater risk of developing insulin resistance. The Homeostatic Model Assessment Insulin Resistance Index (HOMA) is a simple method that provides insulin resistance indices with only the determination of basal plasma glucose and insulin concentrations. OBJECTIVE: To determine the association of insulin resistance and psoriasis according to its severity in patients attending the Teodoro Maldonado Carbo Hospital in the period March 2020 to September 2020. MATERIALS AND METHODS: A cross-sectional, exploratory, descriptive and correlational study was carried out in the area of Dermatology in patients with psoriasis who had the HOMA –IR index measured. RESULTS: A statistically significant correlation was recorded between the HOMA-IR index and the variables weight, abdominal circumference, and (BMI) body mass index, reporting p values = 0,0003; 0,006 y 0,00001 respectively, while for the variable severity according to PASI, the correlation was not statistically significant (p = 0.70). CONCLUSION: Patients with psoriasis and increased weight, abdominal circumference and BMI have a higher prevalence for the development of insulin resistance, the use of the HOMA-IR index represents a useful technique for the evaluation and follow-up of these patients. However, the severity of psoriasis was not an indicator of insulin resistance in this study, possibly a larger sample size is required. KEY WORDS: Psoriasis, Insulin Resistance, HOMA-IR
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Psoriasis, Resistencia a la insulina, Indice Homa-Ir, Estudio transversal, Epidemiología descriptiva, Hospital de Especialidades Dr. Teodoro Maldonado Carbo, Cantón Guayaquil, Ecuador