Complicaciones de los pacientes VIH positivo en tratamiento antirretrovirales atendidos en el Hospital Teodoro Maldonado Carbo, el período del 2016
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2017
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Medicina
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Los antirretrovirales de gran actividad (TARGA) han supuesto una importante disminución de la morbimortalidad de los pacientes con infección por el VIH, pero se ha ensombrecido por la aparición de efectos adversos a largo plazo asociados al TARGA, como acidosis láctica severa, coronariopatía prematura, pancreatitis aguda y alteraciones del metabolismo lipídico, particularmente observadas en pacientes que reciben IP, evidenciado por niveles elevados de colesterol total, triglicéridos (TGL) y colesterol-LDL (LDL-c) y disminución de colesterol HDL (HDL-c). El Objetivo de este estudio fue determinar las complicaciones asociadas al tratamiento antirretroviral en una población de pacientes HIV/SIDA., mediante un estudio observacional, analítico y retrospectivo en la Unidad de Infectología, Hospital Teodoro Maldonado Carbo. Instrumentos: Las técnicas que se utilizaron son de observación directa y la evolución de historias clínicas de cada paciente, como instrumento de trabajo, se utilizó un formulario de datos que fueron procesados y analizados mediante Microsoft Excel y el programa SPSS. Resultados: Se demostró que existe una mayor prevalencia de casos en edades comprendidas de 19 a 45 años, el sexo masculino predomina sobre el femenino relación 62% a 38% se estudio los efectos colaterales producidos por los antirretrovirales aumento de triglicéridos es un 50% y que el 64% de estos pacientes tienen su CD4 por debajo de 350. Conclusión: Los efectos colaterales producidos por los TARGA influyen en la efectividad de los mismos.
The active antiretroviral therapy (HAART) have led to a significant reduction in morbidity and mortality of patients with HIV infection, but it has overshadowed by the emergence of long-term adverse effects associated with HAART, premature coronary artery disease, acute pancreatitis, severe lactic acidosis and alterations in lipid metabolism, particularly observed in patients receiving IP, evidenced by elevated levels of total cholesterol (TGL) triglycerides and LDL-cholesterol (LDL-c) and decrease in cholesterol HDL (HDL-c). The objective of this study was to determine the complications associated with antiretroviral therapy in AIDS patients., through an analytical, observational and retrospective study in the infectious diseases unit, Hospital Teodoro Maldonado Carbo. Instruments: The techniques used are of direct observation and the evolution of medical records of each patient, as a working tool, a form of data that were processed and analysed using Microsoft Excel and SPSS program was used. Results: Showed that there is a higher prevalence of cases aged 19 to 45 years, male predominates over the female ratio 62% to 38% study the side effects of antiretroviral drugs increased triglyceride is 50% and 64% of these patients have their CD4 below 350. Conclusion: The side effects produced by the TARGA influence the effectiveness of them.
The active antiretroviral therapy (HAART) have led to a significant reduction in morbidity and mortality of patients with HIV infection, but it has overshadowed by the emergence of long-term adverse effects associated with HAART, premature coronary artery disease, acute pancreatitis, severe lactic acidosis and alterations in lipid metabolism, particularly observed in patients receiving IP, evidenced by elevated levels of total cholesterol (TGL) triglycerides and LDL-cholesterol (LDL-c) and decrease in cholesterol HDL (HDL-c). The objective of this study was to determine the complications associated with antiretroviral therapy in AIDS patients., through an analytical, observational and retrospective study in the infectious diseases unit, Hospital Teodoro Maldonado Carbo. Instruments: The techniques used are of direct observation and the evolution of medical records of each patient, as a working tool, a form of data that were processed and analysed using Microsoft Excel and SPSS program was used. Results: Showed that there is a higher prevalence of cases aged 19 to 45 years, male predominates over the female ratio 62% to 38% study the side effects of antiretroviral drugs increased triglyceride is 50% and 64% of these patients have their CD4 below 350. Conclusion: The side effects produced by the TARGA influence the effectiveness of them.
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Virus de inmunodeficiencia humana, Antirretrovirales, Epidemiología analítica, Estudios retrospectivos, Hospital de Especialidades Dr. Teodoro Maldonado Carbo, Cantón Guayaquil, Ecuador, Complicaciones