Psoriasis como factor de riesgo en enfermedad cardíaca isquémica, estudio a realizarse en el Hospital Abel Gilbert Pontón período 2014-2015
No hay miniatura disponible
Fecha
2016
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Medicina
Resumen
Recientemente se ha descrito un incremento del riesgo cardiovascular en los pacientes con psoriasis como ocurre en otras enfermedades inflamatorias crónicas. La liberación de gran cantidad de citoquinas proinflamatorias implicadas en la patogenia de la psoriasis podría estar relacionada con la enfermedad cardiovascular.
Se pretende mediante un estudio de casos y controles analizar el perfil de riesgo cardiovascular de aquellos pacientes con psoriasis.
Pacientes y métodos: Se han incluido en el estudio 31 pacientes con psoriasis que acudieron a consulta externa del Hospital Abel Gilbert Ponton durante el período 2014-2015 y 35 pacientes controles con edad y sexo similar. En ambos grupos se estudiaron criterios para síndrome metabólico de acuerdo a los señalados por la Federación Internacional de Diabetes (IDF).
Resultados: El 58.06% de los pacientes con psoriasis presenta criterios para síndrome metabólico frente al 20% de los pacientes controles. En cuanto a la severidad de la psoriasis la forma leve con un 77.8 % presentó mayor asociación con síndrome metabólico.
Los factores de riesgo cardiovascular como alteración en los niveles de HDL- c y triglicéridos tienen mayor porcentaje de prevalencia en grupo de casos (55.5% vs 28.6% y 29% vs 5.71 %) respectivamente, no hubo diferencias significativas en relación a la obesidad. La hipertensión arterial no mostró diferencias significativas entre los dos grupos 16.12 % de los casos frente a 34.28% de los controles. Por el contrario la diabetes mellitus fue más prevalente en el grupo de casos con una relación de 32.25 % versus 2.85 % . En cuanto al biomarcador PCR- US existieron diferencias marcadas para el grupo de casos 38.70% vs 8.57 % en el grupo control.
Conclusiones: La elevada frecuencia con la que se presenta el síndrome metabólico en los pacientes con psoriasis hace necesario la realización de un screening en este grupo para detectar precozmente a aquellos individuos en riesgo e iniciar tratamiento preventivo antes de que se establezca la enfermedad cardiovascular.
Recently it described an increased cardiovascular risk in patients with psoriasis as in other chronic inflammatory diseases. The release of many proinflammatory cytokines involved in the pathogenesis of psoriasis may be related to cardiovascular disease. It is intended by a case study and analyze the cardiovascular risk profile of patients with psoriasis controls. Patients and Methods: We included in the study 31 patients with psoriasis who attended outpatient Abel Gilbert Ponton Hospital during the period 2014-2015 and 35 control patients with similar age and sex. In both groups criteria for metabolic syndrome according to those identified by the International Diabetes Federation (IDF) they were studied. Results: 58.06% of patients with psoriasis presents criteria for metabolic syndrome compared with 20% of control patients. As the severity of psoriasis with mild form 77.8% showed higher association with metabolic syndrome. Cardiovascular risk factors such as altered levels of HDL-c and triglycerides have a higher prevalence rate in case group (55.5% vs 28.6% and 29% vs 5.71%) respectively, there were no significant differences in relation to obesity. Hypertension showed no significant difference between the two groups 16.12% of cases compared with 34.28% of the controls. By contrast diabetes mellitus was more prevalent in the case group with a ratio of 32.25% versus 2.85%. As the PCR-US biomarker marked differences existed for the case group 38.70% vs. 8.57% in the control group. Conclusions: The high frequency of metabolic syndrome occurs in patients with psoriasis necessitates conducting a screening in this group for early detection of those individuals at risk and initiate preventive treatment before cardiovascular disease is established.
Recently it described an increased cardiovascular risk in patients with psoriasis as in other chronic inflammatory diseases. The release of many proinflammatory cytokines involved in the pathogenesis of psoriasis may be related to cardiovascular disease. It is intended by a case study and analyze the cardiovascular risk profile of patients with psoriasis controls. Patients and Methods: We included in the study 31 patients with psoriasis who attended outpatient Abel Gilbert Ponton Hospital during the period 2014-2015 and 35 control patients with similar age and sex. In both groups criteria for metabolic syndrome according to those identified by the International Diabetes Federation (IDF) they were studied. Results: 58.06% of patients with psoriasis presents criteria for metabolic syndrome compared with 20% of control patients. As the severity of psoriasis with mild form 77.8% showed higher association with metabolic syndrome. Cardiovascular risk factors such as altered levels of HDL-c and triglycerides have a higher prevalence rate in case group (55.5% vs 28.6% and 29% vs 5.71%) respectively, there were no significant differences in relation to obesity. Hypertension showed no significant difference between the two groups 16.12% of cases compared with 34.28% of the controls. By contrast diabetes mellitus was more prevalent in the case group with a ratio of 32.25% versus 2.85%. As the PCR-US biomarker marked differences existed for the case group 38.70% vs. 8.57% in the control group. Conclusions: The high frequency of metabolic syndrome occurs in patients with psoriasis necessitates conducting a screening in this group for early detection of those individuals at risk and initiate preventive treatment before cardiovascular disease is established.
Descripción
Palabras clave
Psoriasis, Factores de riesgo, Isquemia miocárdica, Hospital de Especialidades Guayaquil Dr. Abel Gilbert Pontón, Cantón Guayaquil, Ecuador