Comparación del efecto cicatrizante de los extractos hidroalcohólicos de escancel (aerva sanguinolenta L) y llantén (plantago major L) en animales de experimentación
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2018
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Universidad de Guayaquil. Facultad de Ciencias Químicas
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El presente estudio tiene como objetivo establecer preclínicamente el tiempo de cicatrización en heridas de piel mediante la aplicación de los extractos hidroalcohólicos de Escancel (Aerva sanguinolenta L.) y Llantén (Plantago major L); a los extractos y droga cruda se les realizó: tamizaje fitoquímico y parámetros de control de calidad. En el ensayo preclínico se utilizó ratones machos (CD-1); se anestesió y rasuró 3 cm en la región escapular posteriormente se realizó la técnica de punch, se aplicó diariamente: 0.25 % β-Sitosterol, extracto de Llantén y Escancel (10, 20, 30 µL); se evaluó por siete días: tamaño de herida, formación de costra, inflamación, humedad; se logró concluir que el extracto de Llantén tiene mayor efecto cicatrizante presentando 100 % formación de costra en el cuarto día en comparación del extracto de Escancel que fue de 100 % en el quinto día.
The aim of this research is to establish preclinically the healing time in skin wounds through the application of the hydroalcoholic extracts of Escancel (Aerva sanguinolenta L.) and Llantén (Plantago major L); The extracts and raw drug were made: phytochemical screening and quality control parameters. In the preclinical trial, male mice (CD-1) were used; 3 cm was anesthetized and shaved in the scapular region, then the punch technique was performed, it was applied daily: 0.25% β-Sitosterol, extract of Llantén and Escancel (10, 20, 30 µL); it was evaluated for seven days: wound size, scab formation, inflammation, humidity; It was concluded that the Llantén extract has a greater cicatrizing effect, presenting 100% scab formation on the fourth day compared to the Escancel extract, which was 100% on the fifth day
The aim of this research is to establish preclinically the healing time in skin wounds through the application of the hydroalcoholic extracts of Escancel (Aerva sanguinolenta L.) and Llantén (Plantago major L); The extracts and raw drug were made: phytochemical screening and quality control parameters. In the preclinical trial, male mice (CD-1) were used; 3 cm was anesthetized and shaved in the scapular region, then the punch technique was performed, it was applied daily: 0.25% β-Sitosterol, extract of Llantén and Escancel (10, 20, 30 µL); it was evaluated for seven days: wound size, scab formation, inflammation, humidity; It was concluded that the Llantén extract has a greater cicatrizing effect, presenting 100% scab formation on the fourth day compared to the Escancel extract, which was 100% on the fifth day
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EXTRACTO, FLAVONOIDES, CICATRIZANTE, COSTRA