Morbi-mortalidad de las complicaciones pulmonares de la fibrosis quistica en pacientes menores de 10 años. Hospital Dr. Francisco de Icaza Bustamante. Junio 2012-junio 2017 2017
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2018
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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La Fibrosis Quística es una rara enfermedad multisistémica que conduce a una significativa morbilidad y mortalidad. El diagnóstico temprano y el acceso a terapias proporcionan beneficios en nutrición, salud pulmonar y capacidad cognitiva. El objetivo es determinar la morbi-mortalidad de las complicaciones pulmonares de la fibrosis quística en pacientes menores de 10 años del hospital Dr. Francisco de Icaza Bustamante junio 2012-junio 2017. La metodología utilizada fue un estudio de tipo observacional, analítico, retrospectivo y de corte transversal, que incluyó a 138 pacientes con fibrosis quística captados en el periodo antes descrito. La gestión de datos se realizó en hojas de cálculo de Microsoft Excel 2010, para el procesamiento de datos y se empleó el software SPSS versión 21 para el análisis estadístico de la información. De los resultados la complicación clínica más frecuente fue la neumonía que se presentó en el 100% de los pacientes y el índice de mortalidad fue del 2,9% (4). El 84,8% (117) tenían antecedentes de procesos infecciosos a repetición, lo cual representó el factor de riesgo más frecuente en la población de estudio, se encontró asociación estadísticamente significativa entre el desarrollo de complicaciones con la presencia de procesos infecciosos (p 0,004), desnutrición (p 0,001) y la estancia hospitalaria prolongada (p 0,001), los principales agentes infecciosos fueron la pseudomona aeruginosa (80,1%) y el estafilococo aureus con el 52,9%. Las conclusiones finales son que el grupo poblacional más afectado fueron los preescolares de sexo masculino, la neumonía como la complicación respiratoria más frecuente, los principales agentes infecciosos fueron la pseudomona aeruginosa y el estafilococo aureus, el factor de riesgo más común fueron los procesos infecciosos a repetición, la desnutrición y la no adherencia al tratamiento, se encontró asociación estadísticamente significativa entre el desarrollo de complicaciones con la presencia los factores de riesgos antes mencionados y la estancia hospitalaria prolongada, comparado con otros estudios internacionales la frecuencia de complicaciones pulmonares en esta serie de paciente es mayor.
Cystic Fibrosis is a rare multisystem disease that leads to significant morbidity and mortality. Early diagnosis and access to therapies provide benefits in nutrition, lung health and cognitive ability. The objective is to determine the morbidity and mortality of pulmonary complications of cystic fibrosis in patients younger than 10 years of the Dr. Francisco de Icaza Bustamante Hospital June 2012-June 2017. The methodology used was an observational, analytical, retrospective and of cross section, which included 138 patients with cystic fibrosis captured in the period described above. The data management was done in Microsoft Excel 2010 spreadsheets, for data processing and SPSS software version 21 was used for the statistical analysis of the information. Of the results, the most frequent clinical complication was pneumonia that occurred in 100% of the patients and the mortality rate was 2.9% (4). 84.8% (117) had a history of recurrent infectious processes, which represented the most frequent risk factor in the study population; a statistically significant association was found between the development of complications and the presence of infectious processes (p 0.004).), malnutrition (p. 0.001) and prolonged hospital stay (p. 0.001), the main infectious agents were pseudomonas aeruginosa (80.1%) and staphylococcus aureus with 52.9%. The final conclusions are that the most affected population group were male preschoolers, pneumonia as the most frequent respiratory complication, the main infectious agents were pseudomonas aeruginosa and staphylococcus aureus, the most common risk factor were infectious processes. recurrence, malnutrition and non-adherence to treatment, a statistically significant association was found between the development of complications with the presence of the aforementioned risk factors and prolonged hospital stay, compared with other international studies the frequency of pulmonary complications in this series of Patient is older.
Cystic Fibrosis is a rare multisystem disease that leads to significant morbidity and mortality. Early diagnosis and access to therapies provide benefits in nutrition, lung health and cognitive ability. The objective is to determine the morbidity and mortality of pulmonary complications of cystic fibrosis in patients younger than 10 years of the Dr. Francisco de Icaza Bustamante Hospital June 2012-June 2017. The methodology used was an observational, analytical, retrospective and of cross section, which included 138 patients with cystic fibrosis captured in the period described above. The data management was done in Microsoft Excel 2010 spreadsheets, for data processing and SPSS software version 21 was used for the statistical analysis of the information. Of the results, the most frequent clinical complication was pneumonia that occurred in 100% of the patients and the mortality rate was 2.9% (4). 84.8% (117) had a history of recurrent infectious processes, which represented the most frequent risk factor in the study population; a statistically significant association was found between the development of complications and the presence of infectious processes (p 0.004).), malnutrition (p. 0.001) and prolonged hospital stay (p. 0.001), the main infectious agents were pseudomonas aeruginosa (80.1%) and staphylococcus aureus with 52.9%. The final conclusions are that the most affected population group were male preschoolers, pneumonia as the most frequent respiratory complication, the main infectious agents were pseudomonas aeruginosa and staphylococcus aureus, the most common risk factor were infectious processes. recurrence, malnutrition and non-adherence to treatment, a statistically significant association was found between the development of complications with the presence of the aforementioned risk factors and prolonged hospital stay, compared with other international studies the frequency of pulmonary complications in this series of Patient is older.
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Fibrosis quítica, Complicaciones pulmonares, Estudios retrospectivos, Epidemiología descriptiva, Cantón Guayaquil, Ecuador, Hospital del Niño Francisco de Icaza Bustamante, Indicadores de morbimortalidad