Trombocitopenia como valor pronóstico de mortalidad en sepsis neonatal temprana, estudio multicéntrico
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2018
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Medicina
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La sepsis neonatal (SN), es descrita como un síndrome clínico que afecta a los recién nacidos. Las estadísticas del INEC la sitúan como la sexta patología que ocasiona morbilidad neonatal y como la quinta causa de mortalidad. La trombocitopenia es la manifestación hematológica más común asociada a SN. Objetivo: Determinar la fiabilidad de la Trombocitopenia como valor pronóstico de mortalidad en sepsis neonatal temprana. Metodología: Estudio cuantitativo, retrospectivo, descriptivo, observacional, no experimental, analítico, de corte transversal y multicéntrico Resultados: Se analizaron 160 pacientes. Se realizó un análisis univariado con resultados significativos por lo que se prosiguió con un análisis multivariado con asociaciones estadísticamente significativa de 3 variables, trombocitopenia (OR: 1.7; CI: 1.2-2.5; pv: 0.002), Apgar <6 (OR: 2.5; IC: 1.2-5.4; pv: 0.014) y la ruptura prematura de membrana (OR: 2.2; CI: 1.0-4.8; pv: 0.039), considerando la trombocitopenia como el principal factor pronóstico de mortalidad neonatal. Conclusión: Un nivel bajo de plaquetas es el factor pronostico más importante en SN, además que un Apgar <6 y la ruptura prematura de membrana constituyen factores de riesgo también asociados a mortalidad por sepsis neonatal temprana.
Neonatal sepsis (SN) is described as a clinical syndrome that affects newborns. The statistics of the INEC place it as the sixth pathology that causes neonatal morbidity and as the fifth cause of mortality. Thrombocytopenia is the most common hematologic manifestation associated with SN. Objective: Determine the reliability of thrombocytopenia as a prognostic value of mortality in early neonatal sepsis. Methodology: Quantitative, retrospective, descriptive, observational, non-experimental, analytical, cross sectional and multicentre study Results: 160 patients were reported. A univariate analysis was performed with significant results for what was found with a multivariate analysis with statistically significant associations of 3 variables, thrombocytopenia (OR: 1.7; CI: 1.2-2.5; pv: 0.002), Apgar <6 ( OR: 2.5; IC: 1.2-5.4; pv: 0.014) and premature membrane rupture (OR: 2.2; CI: 1.0-4.8; pv: 0.039), considering thrombocytopenia as the factor main prognostic of neonatal mortality . Conclusion: A low level of platelets is the most important prognostic factor in SN, in addition to an Apgar <6 and premature rupture of a membrane is also a mortality factor for early neonatal sepsis
Neonatal sepsis (SN) is described as a clinical syndrome that affects newborns. The statistics of the INEC place it as the sixth pathology that causes neonatal morbidity and as the fifth cause of mortality. Thrombocytopenia is the most common hematologic manifestation associated with SN. Objective: Determine the reliability of thrombocytopenia as a prognostic value of mortality in early neonatal sepsis. Methodology: Quantitative, retrospective, descriptive, observational, non-experimental, analytical, cross sectional and multicentre study Results: 160 patients were reported. A univariate analysis was performed with significant results for what was found with a multivariate analysis with statistically significant associations of 3 variables, thrombocytopenia (OR: 1.7; CI: 1.2-2.5; pv: 0.002), Apgar <6 ( OR: 2.5; IC: 1.2-5.4; pv: 0.014) and premature membrane rupture (OR: 2.2; CI: 1.0-4.8; pv: 0.039), considering thrombocytopenia as the factor main prognostic of neonatal mortality . Conclusion: A low level of platelets is the most important prognostic factor in SN, in addition to an Apgar <6 and premature rupture of a membrane is also a mortality factor for early neonatal sepsis
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SEPSIS NEONATAL, TROSMBOCITOPENIA, MORTALIDAD INFANTIL, FACTORES DE RIESGO, HOSPITAL DE NIÑO FRANCISCO DE ICAZA BUSTAMANTE, HOSPITAL DE NIÑOS DR. ROBERTO GILBERT ELIZALDE, CANTON GUAYAQUIL, ECUADOR