Prohormona n-terminal del péptido natriurético B en hospitalizados por insuficiencia cardíaca, Servicio de Cardiología Hospital Luis Vernaza 2014-2015
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2017
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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Introducción: La prohorma N-terminal del péptido natriurético B (NT-proBNP) es un biomarcador cuya utilidad en insuficiencia cardíaca (IC) con fracción de eyección del ventrículo izquierdo (FEVI) reducida es incierta. Objetivo: Determinar los niveles plasmáticos de NT- proNBP) en pacientes hospitalizados con IC y relacionarlos con parámetros clínicos y ecocardiográficos. Materiales y métodos: se realizó un estudio analítico, observacional, de cohorte retrospectivo, en el Servicio de Cardiología del Hospital Luis Vernaza, en el período comprendido entre los años 2014 y 2015, en pacientes con IC. Se analizó la correlación de los valores de NT- proBNP con la clasificación funcional de IC de la Asociación del Corazón de Nueva York (NYHA) y la FEVI. Se evaluó la sensibilidad y especificidad del NT-proBNP para identificar pacientes con IC con FEVI reducida. Se estableció cuáles fueron los predictores de IC con FEVI reducida. Resultados: NT-proBNP tuvo una adecuada correlación con la FEVI (r = -0.708; p<0.0001)y la clase NYHA (r =0.545; p <0.0001). Un valor de NT -proBNP de 5271 pg/mL permitió identificar IC con FEVI reducida con altas sensibilidad y especificidad (90 % y 70.24 % respectivamente)(AUC 0.87, P <0.0001). En un modelo de regresión logística múltiple, la edad, NT-proBNP y la clase funcional NYHA fueron predictores independientes de IC con FEVI reducida (p <0.0001). Conclusiones: NT-proBNP podría ser un biomarcador útil para reconocer IC con FEVI reducida.
Introduction: The N-terminal prohorm of natriuretic peptide B (NT-proBNP) is a biomarker whose usefulness in heart failure (HF) with reduced left ventricular ejection fraction (LVEF) is uncertain. Objective: To determine the plasma levels of NT-proNBP) in hospitalized patients with HF and to relate them with clinical and echocardiographic parameters. Materials and methods: an analytical, observational, retrospective cohort study was conducted in the Cardiology Service of the Luis Vernaza Hospital, in the period between 2014 and 2015, in patients with HF. We analyzed the correlation of NT-proBNP values with the functional classification of CI of the New York Heart Association (NYHA) and LVEF. The sensitivity and specificity of NT-proBNP was evaluated to identify patients with HF with reduced LVEF. We established the predictors of HF with reduced LVEF. Results: NT-proBNP had an adequate correlation with LVEF (r = -0.708, p <0.0001) and NYHA class (r = 0.545, p <0.0001). A NT-proBNP value of 5271 pg / mL allowed IC to be identified with reduced LVEF with high sensitivity and specificity (90% and 70.24% respectively) (AUC 0.87, P <0.0001). In a multiple logistic regression model, age, NT-proBNP and NYHA functional class were independent predictors of HF with reduced LVEF (p <0.0001). Conclusions: NT-proBNP could be a useful biomarker to recognize HF with reduced LVEF.
Introduction: The N-terminal prohorm of natriuretic peptide B (NT-proBNP) is a biomarker whose usefulness in heart failure (HF) with reduced left ventricular ejection fraction (LVEF) is uncertain. Objective: To determine the plasma levels of NT-proNBP) in hospitalized patients with HF and to relate them with clinical and echocardiographic parameters. Materials and methods: an analytical, observational, retrospective cohort study was conducted in the Cardiology Service of the Luis Vernaza Hospital, in the period between 2014 and 2015, in patients with HF. We analyzed the correlation of NT-proBNP values with the functional classification of CI of the New York Heart Association (NYHA) and LVEF. The sensitivity and specificity of NT-proBNP was evaluated to identify patients with HF with reduced LVEF. We established the predictors of HF with reduced LVEF. Results: NT-proBNP had an adequate correlation with LVEF (r = -0.708, p <0.0001) and NYHA class (r = 0.545, p <0.0001). A NT-proBNP value of 5271 pg / mL allowed IC to be identified with reduced LVEF with high sensitivity and specificity (90% and 70.24% respectively) (AUC 0.87, P <0.0001). In a multiple logistic regression model, age, NT-proBNP and NYHA functional class were independent predictors of HF with reduced LVEF (p <0.0001). Conclusions: NT-proBNP could be a useful biomarker to recognize HF with reduced LVEF.
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Insuficiencia cardiaca, Péptido natriurético encefálico, Epidemiología analítica, Estudios retrospectivos, Hospital Luis Vernaza, Cantón Guayaquil, Ecuador, Prohormona n-terminal