Niveles de ácido úrico en infarto agudo de miocardio, Hospital Luis Vernaza, año 2015 - 2016
Fecha
2017
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
El ácido úrico es un predictor y un factor de riesgo independiente para la enfermedad cardíaca coronaria. La actividad de la xantina oxidasa y el ácido úrico presentan aumento en la síntesis, en virtud de la isquemia tisular. Los objetivos del estudio fueron correlacionar los niveles de ácido úrico con el infarto agudo de miocardio, determinar la relación entre los niveles de ácido úrico con la mortalidad y estancia hospitalaria. Se trata de un estudio analítico, correlacional, retrospectivo, transversal, no experimental, realizado en el Hospital Luis Vernaza. El universo lo constituyó 1102 pacientes con diagnóstico de Infarto Agudo de Miocardio ingresados en el servicio de Cardiología, siendo la población de 172 casos, de los cuales se excluyeron 34, generando un total de 138 pacientes. Se obtuvieron como resultados, que del total de pacientes que participaron en el estudio 96 (70%) eran normouricémicos y 42 (30%) hiperuricémicos. Dentro del grupo de pacientes hiperuricémicos, la proporción de casos femeninos fue mayor (P 0,000 <1). Del total de pacientes fallecidos (11 casos), la mayoría correspondieron al grupo de hombres hiperuricémicos con 6 casos (55%), obteniéndose (P =0.012). El tiempo de estancia hospitalaria fue de leve predominio del grupo de pacientes hiperuricémicos, obteniéndose (P >0.05). Se puede obtener como conclusiones del estudio que la hiperuricemia se presentó en un tercio de los pacientes con infarto agudo de miocardio, esto a su vez se relacionó directamente con la mortalidad y con la estancia hospitalaria.
Uric acid is a predictor and an independent risk factor for coronary heart disease. The activity of xanthine oxidase and uric acid show increased synthesis, due to tissue ischemia. The objectives of the study were correlated with uric acid levels with acute myocardial infarction, to determine the relationship between uric acid levels with mortality and hospital stay. This is an analytical, correlational, retrospective, cross-sectional, non-experimental study performed at the Luis Vernaza Hospital. The universe consisted of 1102 patients with a diagnosis of acute myocardial infarction admitted to the cardiology department, with a population of 172 cases, of which 34 were excluded, generating a total of 138 patients. Results showed that 96 (70%) of the total number of patients participating in the study were normouricemic and 42 (30%) were hyperuricemic. Within the group of hyperuricemic patients, the proportion of female cases was higher (P 0.000 <1). Of the total number of deceased patients (11 cases), the majority corresponded to the group of hyperuricemic men with 6 cases (55%), obtaining (P = 0.012). The length of hospital stay was predominant in the group of hyperuricemic patients, obtaining (P> 0.05). As conclusions of the study, hyperuricemia was present in one third of patients with acute myocardial infarction, once it was directly related to mortality and hospital stay.
Uric acid is a predictor and an independent risk factor for coronary heart disease. The activity of xanthine oxidase and uric acid show increased synthesis, due to tissue ischemia. The objectives of the study were correlated with uric acid levels with acute myocardial infarction, to determine the relationship between uric acid levels with mortality and hospital stay. This is an analytical, correlational, retrospective, cross-sectional, non-experimental study performed at the Luis Vernaza Hospital. The universe consisted of 1102 patients with a diagnosis of acute myocardial infarction admitted to the cardiology department, with a population of 172 cases, of which 34 were excluded, generating a total of 138 patients. Results showed that 96 (70%) of the total number of patients participating in the study were normouricemic and 42 (30%) were hyperuricemic. Within the group of hyperuricemic patients, the proportion of female cases was higher (P 0.000 <1). Of the total number of deceased patients (11 cases), the majority corresponded to the group of hyperuricemic men with 6 cases (55%), obtaining (P = 0.012). The length of hospital stay was predominant in the group of hyperuricemic patients, obtaining (P> 0.05). As conclusions of the study, hyperuricemia was present in one third of patients with acute myocardial infarction, once it was directly related to mortality and hospital stay.
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Infarto del miocardio, Acido úrico, Epidemiología analítica, Estudios retrospectivos, Hospital Luis Vernaza, Cantón Guayaquil, Ecuador