Aspectos clínicos y epidemiológicos de la endometriosis relacionados con el grado de severidad según la clasificación de la RARSM y biomarcadores, Hospital Gineco-Obstétrico Enrique C. Sotomayor. 2015
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2016
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
La endometriosis se caracteriza por la localización de tejido endometrial fuera de la cavidad uterina, también llamado tejido endometrial ectópico. Es una patología crónica, inflamatoria y estrógeno-dependiente por lo cual es más frecuente durante la edad reproductiva, se asocia a dolor pélvico, infertilidad y tumor ovárico (endometrioma). El “goldstandard” para el diagnóstico de esta patología es bajo visión directa por laparoscopía y el análisis histopatológico de las lesiones. Es una patología enigmática desde sus inicios por su sintomatología y su difícil diagnóstico; así como también, de difícil clasificación en cuanto a sus grados de severidad. En 1997, la Sociedad Americana de Medicina Reproductiva fue la creadora de una de las primeras escalas de clasificación de la enfermedad, rASRM (The revised American Society for Reproductive Medicine). Siendo de interés la inclusión de estructuras retroperitoneales y del tabique rectovaginal, se crea la clasificación Enzian (2013), la misma que complementa la rASRM logrando establecer grados de severidad de esta patología de manera más acertada aparentemente. En la actualidad se conoce que estas escalas se complementan muy bien para describir la extensión morfológica de la endometriosis. El objetivo de este estudio será relacionar los aspectos clínicos y epidemiológicos de mujeres con endometriosis con el grado de severidad de la enfermedad según la clasificación rASRM - Enzian y biomarcadores como el CA125. Este proyecto será de tipo descriptivo, correlacional, de diseño transversal y prospectivo. Se llevará a cabo en el Servicio de Cirugía Mínima Invasiva del Hospital Enrique C. Sotomayor. Para el efecto se reclutará mujeres quienes tengan endometriosis clasificadas según el grado de severidad, y se tomarán los datos clínicos en una hoja de recolección para su correlación posterior. Este estudio permitirá ampliar el conocimiento en cuanto a la endometriosis y a su sintomatología relacionada con los grados de severidad. De tal manera, que enfocados en el cuadro clínico podamos llegar a un diagnóstico y tratamiento más temprano, permitiendo la preservación de la fertilidad y corregir el dolor en estas mujeres.
Endometriosis is characterized by the location of endometrial tissue outside the uterine cavity, also called ectopic endometrial tissue. It is an estrogen-dependent disease for which it is most common during the childbearing age, it is associated with pelvic pain, infertility and ovarian tumor (endometrioma). The "goldstandard" for the diagnosis of this disease is under direct vision by laparoscopy and histopathological analysis of the injuries. It is an enigmatic disease since its inception by its symptoms and its diagnosis difficult. Also it is difficult to classify in terms of their degrees of severity. In 1997, the American Society for Reproductive Medicine was the creator of one of the first rating scales disease, rASRM (The revised American Society for Reproductive Medicine). Being of interest, including retroperitoneal structures, the Enzian table is created, it complements the rASRM, managing to establish degrees of severity of this disease apparently more successful way. At present these scales is known are highly complementary to describe the morphological extension of endometriosis. The aim of this study is to relate the clinical and epidemiological aspects of women with endometriosis with grade disease severity according to the classification rASRM - Enzian and biomarker CA125. This project will, correlational, descriptive transversal and prospective design. It will be held at the Department of Minimally Invasive Surgery Hospital Enrique C. Sotomayor, to the effect women who have endometriosis classified according to the degree of severity recruit, clinical data are taken in a collection sheet for further correlation. This study will expand knowledge regarding the endometriosis and its symptoms related to degrees of severity. So, that focused on the clinical picture we can reach an earlier diagnosis and treatment according to the severity of the endometriosis, being our main objective the preservation of fertility in these women.
Endometriosis is characterized by the location of endometrial tissue outside the uterine cavity, also called ectopic endometrial tissue. It is an estrogen-dependent disease for which it is most common during the childbearing age, it is associated with pelvic pain, infertility and ovarian tumor (endometrioma). The "goldstandard" for the diagnosis of this disease is under direct vision by laparoscopy and histopathological analysis of the injuries. It is an enigmatic disease since its inception by its symptoms and its diagnosis difficult. Also it is difficult to classify in terms of their degrees of severity. In 1997, the American Society for Reproductive Medicine was the creator of one of the first rating scales disease, rASRM (The revised American Society for Reproductive Medicine). Being of interest, including retroperitoneal structures, the Enzian table is created, it complements the rASRM, managing to establish degrees of severity of this disease apparently more successful way. At present these scales is known are highly complementary to describe the morphological extension of endometriosis. The aim of this study is to relate the clinical and epidemiological aspects of women with endometriosis with grade disease severity according to the classification rASRM - Enzian and biomarker CA125. This project will, correlational, descriptive transversal and prospective design. It will be held at the Department of Minimally Invasive Surgery Hospital Enrique C. Sotomayor, to the effect women who have endometriosis classified according to the degree of severity recruit, clinical data are taken in a collection sheet for further correlation. This study will expand knowledge regarding the endometriosis and its symptoms related to degrees of severity. So, that focused on the clinical picture we can reach an earlier diagnosis and treatment according to the severity of the endometriosis, being our main objective the preservation of fertility in these women.
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Endometriosis, Epidemiología descriptiva, Biomarcadores, Clasificación RASRM, Hospital Gineco-Obstétrico Enrique C. Sotomayor, Cantón Guayaquil, Ecuador