La proteina c reactiva ultrasensible marcador biológico emergente en hipercolesterolemia como factor de riesgo cardiovascular, algoritmo diagnóstico
No hay miniatura disponible
Fecha
2016
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
El aumento de la proteína c reactiva ultrasensible (PCRus) en pacientes con hipercolesterolemia que formaron una placa de ateroma en los vasos sanguíneos lleva a una inflamación del endotelio, por lo que esta betaglobulina hay que detectarla a tiempo en sus niveles mínimos. El objetivo general de este estudio es demostrar la utilización de la proteína c reactiva ultrasensible y la relación que tiene con el aumento del colesterol, como marcador biológico y factor de riesgo respectivamente. Se plantea realizar un algoritmo diagnóstico para el Hospital Teodoro Maldonado Carbo de la ciudad de Guayaquil como apoyo en los consultorios médicos y áreas de hospitalización con el fin de disminuir la morbimortalidad de los pacientes que acuden a esta casa de salud. Este estudio de tipo cualitativo permite recopilar toda la información sobre el tema en las revisiones bibliográficas y tomarlas como base en la propuesta y discusión al hacer una comparación de resultados actuales de laboratorio y los anteriores en estudios de los referentes empíricos. En la propuesta se elabora un algoritmo diagnostico en el que consta las pruebas solicitadas sus valores de referencia y el protocolo a seguir si estas dan como resultado normal o aumentada. En la población estudiada la PCRus está relacionada con el aumento del colesterol en sangre este a su vez con la formación de una placa de ateroma en los vasos coronarios y las proteínas de baja densidad (LDLc ) las que van en aumento frente a las de alta densidad (HDLc) lo que constituye un alto riesgo para desarrollar un evento cardiovascular (ECV).
Increased C-reactive protein (hsCRP) in patients with hypercholesterolemia who formed an atherosclerotic plaque in blood vessels leads to inflammation of the endothelium, so this betaglobulina have to catch it early at their lowest levels. The overall objective of this study is to demonstrate the use of C-reactive protein ultrasensitive and the relationship with increased cholesterol, as biomarker and risk factor respectively. It arises a diagnosis algorithm for Hospital Teodoro Maldonado Carbo city of Guayaquil as support in medical and hospital areas in order to reduce morbidity and mortality of patients who come to this house health clinics. This qualitative study allows to gather all information on the subject in literature reviews and use them as the basis of the proposal and discussion by making a comparison current laboratory results and previous studies of the empirical referents. In the proposal a diagnostic algorithm consisting in testing is made requested their reference values and protocol to follow if they give normal or increased as a result. In the studied population hsCRP is related to the increase blood cholesterol this in turn with the formation of an atherosclerotic plaque in the vessels coronary and proteins of low density (LDL-C) which are rising against the high density (HDL) which is a high risk for a cardiovascular event (CVD).
Increased C-reactive protein (hsCRP) in patients with hypercholesterolemia who formed an atherosclerotic plaque in blood vessels leads to inflammation of the endothelium, so this betaglobulina have to catch it early at their lowest levels. The overall objective of this study is to demonstrate the use of C-reactive protein ultrasensitive and the relationship with increased cholesterol, as biomarker and risk factor respectively. It arises a diagnosis algorithm for Hospital Teodoro Maldonado Carbo city of Guayaquil as support in medical and hospital areas in order to reduce morbidity and mortality of patients who come to this house health clinics. This qualitative study allows to gather all information on the subject in literature reviews and use them as the basis of the proposal and discussion by making a comparison current laboratory results and previous studies of the empirical referents. In the proposal a diagnostic algorithm consisting in testing is made requested their reference values and protocol to follow if they give normal or increased as a result. In the studied population hsCRP is related to the increase blood cholesterol this in turn with the formation of an atherosclerotic plaque in the vessels coronary and proteins of low density (LDL-C) which are rising against the high density (HDL) which is a high risk for a cardiovascular event (CVD).
Descripción
PDF
Palabras clave
Proteína c-reactiva, Hipercolesterolemia, Factores de riesgo, Hospital de Especialidades Dr. Teodoro Maldonado Carbo, Cantón Guayaquil, Ecuador, Algoritmos