Comparación farmacológica (efecto antiinflamatorio) y toxicológica de extractos de tres variedades de Tropaeolum tuberosum R&P en animales de experimentación
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2019
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Universidad de Guayaquil. Facultad de Ciencias Químicas
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Tropaeolum tuberosum R&P es una planta usada en medicina ancestral y como alimento, por consiguiente la finalidad de esta investigación es comparar el efecto antiinflamatorio y la toxicidad aguda oral de los extractos de tres variedades de Tropaeolum tuberosum variedad amarilla, rosada y negra utilizando ratones machos de la cepa CD-1. Se realizó la evaluación de actividad antiinflamatoria utilizando un modelo de inflamación local por xileno. En cuanto a la evaluación toxicológica se realizó con una dosis oral única de
2000 mg/kg. Finalmente se comprobó que la variedad rosada posee un 16% de inhibición en comparación a la variedad amarilla y variedad negra. En la evaluación de toxicidad aguda oral no se observaron alteraciones en los signos clínicos de los biomodelos. En conclusión la variedad rosada posee mayor efecto antiinflamatorio, y los ratones no presentaron signos de toxicidad al observar forma y coloración normal en los órganos extraídos.
The plant Tropaeolum tuberosum R&P (mashua) has been commonly used in ancestral medicine and as a food source, however, its properties and inocuity are not completely investigated. The aim of this study was to verify and compare the anti-inflammatory effect and acute oral toxicity of three varieties of Tropaeolum tuberosum R&P: yellow, pink and black mashua using male mice of the CD1strain. The anti-inflammatory activity was studied applying a model of induced local inflammation by xylene. The toxicological evaluation was performed with a unique oral dose of 2000 mg/kg. The pink variety mediated 16% inhibition of inflammation compared to the yellow and black variants. The toxicity evaluation indicated no alteration in clinical signs and macro morphology. In conclusion, the pink variety mediated stronger anti-inflammatory effect and there was no toxicity observed at the tested dose in analyzed organs.
The plant Tropaeolum tuberosum R&P (mashua) has been commonly used in ancestral medicine and as a food source, however, its properties and inocuity are not completely investigated. The aim of this study was to verify and compare the anti-inflammatory effect and acute oral toxicity of three varieties of Tropaeolum tuberosum R&P: yellow, pink and black mashua using male mice of the CD1strain. The anti-inflammatory activity was studied applying a model of induced local inflammation by xylene. The toxicological evaluation was performed with a unique oral dose of 2000 mg/kg. The pink variety mediated 16% inhibition of inflammation compared to the yellow and black variants. The toxicity evaluation indicated no alteration in clinical signs and macro morphology. In conclusion, the pink variety mediated stronger anti-inflammatory effect and there was no toxicity observed at the tested dose in analyzed organs.
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TROPAEOLUM TUBEROSUM R&P (MASHUA), EFECTO ANTIINFLAMATORIO, TOXICIDAD AGUDA ORAL