Dosis bajas de aspirina en la prevención de preeclampsia y complicaciones neonatales en gestantes de alto riego obstétrico
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2019
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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Antecedentes: El uso de ASA como profilaxis contra el desarrollo de preeclampsia en gestantes con riesgo de padecerla es una práctica bastante extendida en todo el mundo a pesar de que su utilidad ha sido cuestionada. En el hospital Teodoro Maldonado Carbo se utiliza a dosis de 100 y 150 mg y actualmente su uso ha tomado relevancia ante el incremento de la incidencia de casos.Objetivo: Determinar el nivel de disminución de riesgo de la del uso de bajas de Aspirina en la profilaxis de preeclampsia en gestante con alto riesgo obstetrico de preeclampsia. Materiales y Métodos: se realizó un estudiode cohorte en el que se incluyerron 97 gestantes con alto riesgo de desarrollor preeclampsia atendido en la consulta de Alto Riesgo Obstetrico del Hospital Teodoro Maldonado Carbo Guayaquil Ecuador. 34 pacientes elegidos de manera no aleatoria indicada con ASA profiláctica a dosis de 100 o 150mg desde las 12 semanas de gestación y 63 pacientes que no la recibieron. Se establecio identificaron al final de estudio la prevalencia de preeclampsia por grupo y se tomó como referencia los tradicionales. Resultados: La prevalencia de preeclampsia fue alta (42,3%) El antecedente de obecidad se asoció estadisticamente al desarrollo de preeclampsia (31,7% vs7,1%; P 0,002) El usos de ASA profilactica se asocia a una dismunición de la prevalencia de desarrollar preeclampsia 29,4% Vs 49,2% P =,=47). El uso de ASA profiláctica aumenta el riego de no desarrollar preeclampsia (RR 1;390; IC95% 1, 003 -1,925) Conclusiones: la administración de ASA profiláctica disminuye de maner leve el riegode desarrollar preeclampsisa en pacientes con alto riesgo de padecerla.
Background: The use of ASA as prophylaxis against the development of preeclampsia in pregnant women at risk of developing it is a widespread practice throughout the world, despite the fact that its usefulness has been questioned. In the hospital Teodoro Maldonado Carbo is used at doses of 100 and 150 mg and currently its use has taken relevance to the increase in the incidence of cases. Objective: Determine the level of risk reduction of the use of Aspirin losses in the prophylaxis of preeclampsia in pregnant women with high obstetric risk of preeclampsia. Materials and Methods: A cohort study was carried out in which 97 pregnant women with a high risk of developing preeclampsia treated at the Obstetric High Risk Clinic of Hospital Teodoro Maldonado Carbo Guayaquil Ecuador were included. 34 patients chosen non-randomly indicated with prophylactic ASA at doses of 100 or 150mg from 12 weeks of gestation and 63 patients who did not receive it. The prevalence of preeclampsia by group was identified at the end of the study and the traditional ones were taken as reference. Results: The prevalence of preeclampsia was high (42.3%) The antecedent of obese was statistically associated with the development of preeclampsia (31.7% vs7.1%, P 0.002) The use of prophylactic ASA is associated with a decrease in the prevalence of preeclampsia. prevalence of developing preeclampsia 29.4% Vs 49.2% P =, = 47). The use of prophylactic ASA increases the risk of not developing preeclampsia (RR 1; 390; 95% CI 1, 003 -1,925) Conclusions: Prophylactic ASA administration slightly reduces the risk of developing preeclampsia in patients at high risk of suffering from it.
Background: The use of ASA as prophylaxis against the development of preeclampsia in pregnant women at risk of developing it is a widespread practice throughout the world, despite the fact that its usefulness has been questioned. In the hospital Teodoro Maldonado Carbo is used at doses of 100 and 150 mg and currently its use has taken relevance to the increase in the incidence of cases. Objective: Determine the level of risk reduction of the use of Aspirin losses in the prophylaxis of preeclampsia in pregnant women with high obstetric risk of preeclampsia. Materials and Methods: A cohort study was carried out in which 97 pregnant women with a high risk of developing preeclampsia treated at the Obstetric High Risk Clinic of Hospital Teodoro Maldonado Carbo Guayaquil Ecuador were included. 34 patients chosen non-randomly indicated with prophylactic ASA at doses of 100 or 150mg from 12 weeks of gestation and 63 patients who did not receive it. The prevalence of preeclampsia by group was identified at the end of the study and the traditional ones were taken as reference. Results: The prevalence of preeclampsia was high (42.3%) The antecedent of obese was statistically associated with the development of preeclampsia (31.7% vs7.1%, P 0.002) The use of prophylactic ASA is associated with a decrease in the prevalence of preeclampsia. prevalence of developing preeclampsia 29.4% Vs 49.2% P =, = 47). The use of prophylactic ASA increases the risk of not developing preeclampsia (RR 1; 390; 95% CI 1, 003 -1,925) Conclusions: Prophylactic ASA administration slightly reduces the risk of developing preeclampsia in patients at high risk of suffering from it.
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MUJERES EMBARAZADAS, PREECLAMSIA, PROFILAXIS, EMBARAZO DE ALTO RIESGO, ASPIRINA, HOSPITAL DE ESPECIALIDADES DR. TEODORO MALDONADO CARBO, CANTON GUAYAQUIL, ECUADOR