Demostrar la importancia de realizar el examen de hepatitis core y hepatitis B por quimioluminiscencia en donantes de sangre
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2014
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Tecnología Médica
Resumen
La utilidad de determinar anti – HBc IgM es para el diagnóstico de hepatitis aguda en período de ventana, en que aún no han aparecido anti – HBs y el HBsAg ya se ha negativizado. Formación activa de anticuerpos se produce generalmente transcurridos tres meses desde infección, y 5 a 14 días luego de aparición HbcAg. Dan positivos luego de desaparición del HbsAg y son negativos en 9% de pacientes con hepatitis B aguda en primeras dos semanas de enfermedad. Frecuentemente es asintomática o sólo se manifiesta por síntomas inespecíficos como cansancio o disminución de apetito. Ocasionalmente presentan exacerbaciones de actividad inflamatoria del hígado que pueden traducirse en exacerbaciones de síntomas. En medida que infección produce un daño mayor en hígado, pueden manifestarse síntomas de cirrosis hepática. 10 a 20% de pacientes pueden tener manifestaciones extra-hepáticas de enfermedad, más frecuentemente vasculitis y glomerulonefritis. Pruebas necesarias en donantes que son personas con actitud positiva y piensan que donar sangre es útil para salvar vida, algo necesario y saludable. Infección actual o reciente, es positivo antes de que inicien primeros síntomas y aparece en todos casos de infección aguda, incluso en ausencia de HBsAg (periodo de ventana y hepatitis fulminante), es marcador de elección para catalogar una hepatitis aguda como causada por VHB. Este estudio presenta como objetivo Concienciar que Anticuerpos Core IgM de Hepatitis debe ser analizado en todo donante de sangre de esta manera, informar a comunidad importancia de realizar este tipo de Anticuerpo.
The utility of determining anti-HBc IgM is for the diagnosis of acute hepatitis in the window period, in which anti-HBs have not yet appeared and HBsAg has already been negativized. Active antibody formation generally occurs three months after infection, and 5 to 14 days after HbcAg. They are positive after the disappearance of HbsAg and are negative in 9% of patients with acute hepatitis B in the first two weeks of illness. It is often asymptomatic or only manifested by nonspecific symptoms such as tiredness or decreased appetite. Occasionally they have exacerbations of inflammatory activity of the liver that can result in exacerbations of symptoms. As infection causes major liver damage, symptoms of liver cirrhosis may manifest. 10 to 20% of patients may have extra-hepatic manifestations of disease, more frequently vasculitis and glomerulonephritis. Necessary tests in donors who are people with a positive attitude and think that donating blood is useful for saving life, something necessary and healthy. Current or recent infection, it is positive before the first symptoms begin and appears in all cases of acute infection, even in the absence of HBsAg (window period and fulminant hepatitis), it is a marker of choice for cataloging acute hepatitis as caused by HBV. This study aims to raise awareness that Core IgM Hepatitis Antibodies should be analyzed in all blood donors in this way, inform the community of the importance of performing this type of Antibody.
The utility of determining anti-HBc IgM is for the diagnosis of acute hepatitis in the window period, in which anti-HBs have not yet appeared and HBsAg has already been negativized. Active antibody formation generally occurs three months after infection, and 5 to 14 days after HbcAg. They are positive after the disappearance of HbsAg and are negative in 9% of patients with acute hepatitis B in the first two weeks of illness. It is often asymptomatic or only manifested by nonspecific symptoms such as tiredness or decreased appetite. Occasionally they have exacerbations of inflammatory activity of the liver that can result in exacerbations of symptoms. As infection causes major liver damage, symptoms of liver cirrhosis may manifest. 10 to 20% of patients may have extra-hepatic manifestations of disease, more frequently vasculitis and glomerulonephritis. Necessary tests in donors who are people with a positive attitude and think that donating blood is useful for saving life, something necessary and healthy. Current or recent infection, it is positive before the first symptoms begin and appears in all cases of acute infection, even in the absence of HBsAg (window period and fulminant hepatitis), it is a marker of choice for cataloging acute hepatitis as caused by HBV. This study aims to raise awareness that Core IgM Hepatitis Antibodies should be analyzed in all blood donors in this way, inform the community of the importance of performing this type of Antibody.
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Hepatitis B, Antígenos del núcleo de la hepatitis B, Hospital Gineco-Obstétrico Enrique C. Sotomayor, Cantón Guayaquil, Ecuador, Donantes de sangre, Quimioluminiscencia