Determinar la procalcitonina en pacientes sépticos para confirmar la relación con la antibioticoterapia adecuada estudio a realizarse en el Laboratorio Clínico de la Clínica Alcívar de la ciudad de Guayaquil, período 2013.
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2014
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Tecnología Médica
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La sepsis en las Unidades de Cuidados Intensivos (UCI) continúa siendo un gran reto para los médicos que practican la medicina clínica, ya que lleva en el peor de los casos a la muerte, por disfunción orgánica múltiple. La presente investigación titulada: Determinar valores de procalcitonina como control en pacientes sépticos confirmando antibioticoterapia adecuada. En este sentido se elaboró el estudio de campo, considerando la utilidad de la determinación de la procalcitonina, de los los resultados del trabajo en laboratorio clínico que permitirán la indicación del tratamiento antibiótico adecuado a los pacientesw del post-operatorio ingresados en la Unidad de Cuidados intensivos de la Clínica Alcívar de la ciudad de Guayaquil, durante el año 2013. Fueron objeto de estudio 100 pacientes tomados en consideración como muestra extraída de la población de internos en esta unidad, el número de pacientes con valores elevados de procalcitonina fue de equivalente al 54%, de los 100 pacientes en estudio, el 62% fueron varones, 36% estuvieron ingresados en un promedio de 4 a 6 días, 48% estaban bajo tratamiento antibiótico, 41% estuvieron ingresados por causas de politraumatismos, el 93% tuvieron síntomas de fiebre como indicador de sepsis y el 54% mostraron valores elevados de procalcitonina. Se realizó un cuadro comparativo con la procalcitonina obtenida mediante método de fluorescencia ELFA, los resultados de esta fueron más elevados que las otras pruebas de rutina. La investigación es correlacional, diagnóstica y descriptiva, la cual corresponde a un diseño de tipo longitudinal con cohorte prospectivo, porque los datos que se obtendrán como resultado a partir de los meses de junio a diciembre del año 2013, permitiendo establecer la utilidad y medición del nivel de procalcitonina, para diagnóstico de Sepsis y confirmación de antibioticoterapia adecuada en pacientes de la unidad de cuidados intensivos que se le realice la prueba en el Laboratorio Clínico de la clínica Alcívar de la ciudad de Guayaquil. El estudio confirmó mediante los resultados obtenidos y la literatura, que la procalcitonina es útil para el diagnóstico de sepsis y confirmación de antibioticoterapia.
Sepsis in the Intensive Care Units (ICU) continues to be a great challenge for doctors who practice clinical medicine, since it leads in the worst case to death, due to multiple organic dysfunction. The present research entitled: Determine procalcitonin values as a control in septic patients confirming adequate antibiotic therapy. In this sense, the field study was prepared, considering the usefulness of procalcitonin determination, of the results of the clinical laboratory work that will allow the indication of adequate antibiotic treatment to post-operative patientsw admitted to the Care Unit intensive of the Alcívar Clinic of the city of Guayaquil, during the year 2013. 100 patients were considered as a sample taken from the population of inmates in this unit, the number of patients with high procalcitonin values was equivalent to 54%, of the 100 patients under study, 62% were male, 36% were admitted in an average of 4 to 6 days, 48% were under antibiotic treatment, 41% were admitted for causes of polytrauma, 93% had symptoms of fever as an indicator of sepsis and 54% showed elevated procalcitonin levels. A comparative picture was made with the procalcitonin obtained by ELFA fluorescence method, the results of this were higher than the other routine tests. The research is correlational, diagnostic and descriptive, which corresponds to a longitudinal type design with prospective cohort, because the data that will be obtained as a result from the months of June to December of the year 2013, allowing to establish the utility and measurement of the procalcitonin level, for diagnosis of Sepsis and confirmation of adequate antibiotic therapy in patients of the intensive care unit who undergo the test in the Clinical Laboratory of the Alcívar clinic of the city of Guayaquil. The study confirmed through the results obtained and the literature, that procalcitonin is useful for the diagnosis of sepsis and confirmation of antibiotic therapy.
Sepsis in the Intensive Care Units (ICU) continues to be a great challenge for doctors who practice clinical medicine, since it leads in the worst case to death, due to multiple organic dysfunction. The present research entitled: Determine procalcitonin values as a control in septic patients confirming adequate antibiotic therapy. In this sense, the field study was prepared, considering the usefulness of procalcitonin determination, of the results of the clinical laboratory work that will allow the indication of adequate antibiotic treatment to post-operative patientsw admitted to the Care Unit intensive of the Alcívar Clinic of the city of Guayaquil, during the year 2013. 100 patients were considered as a sample taken from the population of inmates in this unit, the number of patients with high procalcitonin values was equivalent to 54%, of the 100 patients under study, 62% were male, 36% were admitted in an average of 4 to 6 days, 48% were under antibiotic treatment, 41% were admitted for causes of polytrauma, 93% had symptoms of fever as an indicator of sepsis and 54% showed elevated procalcitonin levels. A comparative picture was made with the procalcitonin obtained by ELFA fluorescence method, the results of this were higher than the other routine tests. The research is correlational, diagnostic and descriptive, which corresponds to a longitudinal type design with prospective cohort, because the data that will be obtained as a result from the months of June to December of the year 2013, allowing to establish the utility and measurement of the procalcitonin level, for diagnosis of Sepsis and confirmation of adequate antibiotic therapy in patients of the intensive care unit who undergo the test in the Clinical Laboratory of the Alcívar clinic of the city of Guayaquil. The study confirmed through the results obtained and the literature, that procalcitonin is useful for the diagnosis of sepsis and confirmation of antibiotic therapy.
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POLIPEPTICO ALFA RELACIONADO CON CALCITONINA, SEPSIS, ANTIBIOTICOTERAPIA, HOSPITAL ALCIVAR, CANTON GUAYAQUIL, ECUADOR, TECNICA DE LABORATORIO CLINICO