Evaluación del cumplimiento de las norma, preclínico de calidad, de dos medicamentos gastroprotectores de origen natural, que se comercializan en la ciudad de Quito
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2013
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
El presente trabajo de investigación tiene por objeto determinar si dos medicamentos de origen natural con actividad gastroprotectora que se comercializan en la ciudad de Quito, son eficaces, seguros y cumplen con estándares de calidad exigidos nacionalmente e internacionalmente.
Mediante una encuesta en los establecimientos de venta de productos naturales de uso medicinal de la ciudad de Quito, se determina que, los productos Gastriten® y Drago® Live, son los medicamentos más vendidos.
La evaluación de los parámetros de calidad física, química y microbiológica permitió comprobar que, los medicamentos Gastriten® y Drago® Live cumplen con las normas de calidad exigidas para soluciones orales y contienen las plantas declaradas en la formulación.
A través de la evaluación preclínica de la actividad gastroprotectora de Gastriten® y Drago® Live se demuestra que, presentan un porcentaje de Inhibición del Índice de Ulceración igual o mayor que el Omeprazol.
Mediante la evaluación preclínica de la toxicidad de Gastriten® y Drago® Live, se demuestra que no hay evidencian de toxicidad, por tanto son seguros.
The present research has as its objective to determine whether two natural medicines with attributed gastroprotective activity, commercialized in Quito, Ecuador, are effective, safe and meet international and national standards. The selection of two drugs for this research was made after an inquiry to stores that sell natural products for medicinal purposes in Quito, Ecuador, activity that permitted to determine that Gastriten® and Drago® Live are the gastroprotective drugs of natural origin most sold and recommended. The evaluation of physical, chemical and microbiological parameters conducted to establish that two different batches of Gastriten® y Drago®Live fulfilled the quality standards required for oral solutions and contained the plants declared in their formula. The preclinical evaluation of the gastroprotective activity of Gastriten® y Drago® Live, permitted to determine present percentages of inhibition with the Index of Ulceration same or higer than drug Omeprazol The preclinical evaluation of the toxicity of the drugs showed that the two different batches of Gastriten® and Drago® Live do not present toxicity the two evaluated natural drugs are safe.
The present research has as its objective to determine whether two natural medicines with attributed gastroprotective activity, commercialized in Quito, Ecuador, are effective, safe and meet international and national standards. The selection of two drugs for this research was made after an inquiry to stores that sell natural products for medicinal purposes in Quito, Ecuador, activity that permitted to determine that Gastriten® and Drago® Live are the gastroprotective drugs of natural origin most sold and recommended. The evaluation of physical, chemical and microbiological parameters conducted to establish that two different batches of Gastriten® y Drago®Live fulfilled the quality standards required for oral solutions and contained the plants declared in their formula. The preclinical evaluation of the gastroprotective activity of Gastriten® y Drago® Live, permitted to determine present percentages of inhibition with the Index of Ulceration same or higer than drug Omeprazol The preclinical evaluation of the toxicity of the drugs showed that the two different batches of Gastriten® and Drago® Live do not present toxicity the two evaluated natural drugs are safe.
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Preparaciones de origen natural, Actividad gastroprotectora, Cantón Quito, Ecuador