Estudio preclínico normo-glucemiante de los extractos de las hojas de insulina (justicia secunda Vahl) en ratones
Fecha
2019
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
El uso de las plantas medicinales para tratar enfermedades se lleva a cabo desde hace varios años es por ello que en el presente estudio pre-clínico se realizó la evaluación del efecto normo-glucemiante de los extractos de las hojas de la planta Justicia secunda Vahl Induciendo hiperglicemia en ratones con solución de glucosa al
25%. Los ratones fueron divididos en siete grupos: grupo control normal (A), el grupo glucosa solamente (B), grupo metformina de 500 mg (C), los dos grupos (D y E) extracto etanólico en dosis de “40 μL – 80 μL” y los dos grupos (F y G) extracto acuoso en dosis de “40 μL – 80 μL”. Los resultados mostraron que los extractos etanólico y acuoso en dosis de 40 μL disminuyeron los niveles de glucosa a 182,6 mg/dl y 173 mg/dl respectivamente. Un comportamiento parecido experimento el extracto etanólico en dosis de 80 μL disminuyo los niveles de glucosa a 145,3 mg/dl. Por otro lado, el extracto acuoso a la misma dosis no presento disminución alguna.
The use of medicinal plants to treat illnesses it takes place since few years ago that`s why in the current pre-clinic research get realized the evaluation of the Normoglycemia effect from leaves extracts of the (Justice secunda Vahl) plant introducing hiperglicemine into mice with glucosa to 25%. The mices were divided in 7 groups: normal control group (A), only the glucose group (B), group metmorfina de 500mg (C), both groups (D and E) ethanolic extract in doses of 40 – 80 and the two groups (F and G) watery extract in doses of 40 – 80. The results shows that ethanolic and watery extracts in doses of 40 decrease the level of glucose to 182.6 mg/dl and 173 mg/dl respectively. At the same way, ethanolic extract in dose of 80 decreased the levels of glucose to 145.3 mg/dl. On the other side, the acuose extract at the same dose didn’t present any decrease.
The use of medicinal plants to treat illnesses it takes place since few years ago that`s why in the current pre-clinic research get realized the evaluation of the Normoglycemia effect from leaves extracts of the (Justice secunda Vahl) plant introducing hiperglicemine into mice with glucosa to 25%. The mices were divided in 7 groups: normal control group (A), only the glucose group (B), group metmorfina de 500mg (C), both groups (D and E) ethanolic extract in doses of 40 – 80 and the two groups (F and G) watery extract in doses of 40 – 80. The results shows that ethanolic and watery extracts in doses of 40 decrease the level of glucose to 182.6 mg/dl and 173 mg/dl respectively. At the same way, ethanolic extract in dose of 80 decreased the levels of glucose to 145.3 mg/dl. On the other side, the acuose extract at the same dose didn’t present any decrease.
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INSULINA, JUSTICIA SECUNDA VAHL, HIPERGLUCEMIA, METFORMINA, EFECTO NORMOGLICEMIANTE