Falla multiorgánica en pacientes inmunocomprometidos por virus de inmunodeficiencia humana con histoplasmosis
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2020
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Medicina
Resumen
La Histoplasmosis es una enfermedad micótica presente en pacientes con síndrome de inmunodeficiencia adquirida, la misma que es capaz de desarrollar complicaciones graves, siendo una de ellas la falla multiorgánica. El objetivo general es determinar los factores que se asocian en el desarrollo de falla orgánica múltiple en pacientes con VIH del Hospital de Infectología Dr. José Daniel Rodríguez Maridueña de enero a diciembre del año 2017 -2019. Es una investigación de diseño descriptivo, documental, de tipo cohorte transversal, estadístico, observacional, no experimental. Los datos empleados se obtuvieron del departamento de archivo clínico y estadística de dicho Hospital. Los resultados reportan que el grupo de edades más frecuente es de pacientes de 23 a 32 años representando un 45% de los pacientes, el 81% corresponde a varones, el 76% resultaron relacionarse a un nivel socioeconómico bajo, el 69% presentaron mala adherencia por inconstancia en la toma de su tratamiento antirretroviral, el 84% de los pacientes se coinfectaron con tuberculosis, la mortalidad de los pacientes está íntimamente relacionada con el diagnóstico tardío de la enfermedad, representado un 23% de pacientes que acudieron al hospital después de 15 días iniciados sus síntomas, las manifestaciones clínicas más frecuentes en un 47% de los pacientes resultaron presentar sintomatología respiratoria. En conclusión los factores que influyeron en desencadenar falla multiorgánica en pacientes con Histoplasmosis fue el factor socioeconómico bajo, el diagnóstico tardío y la mala adherencia al tratamiento antirretroviral.
Histoplasmosis is a fungal disease present in patients with acquired immunodeficiency syndrome, which can develop serious complications, one of them being multi-organ failure. The general objective is to determine the factors that are associated in the development of multiple organ failure in patients with HIV at the Hospital de Infectología Dr. José Daniel Rodríguez Maridueña from January to December of the year 2017 -2019. It is a descriptive, documentary, cross-sectional cohort-type, statistical, observational, non-experimental research. The data used were obtained from the clinical and statistical archive department of said Hospital. The results report that the most frequent age group is patients from 23 to 32 years old, representing 45% of the patients, 81% correspond to men, 76% were related to a low socioeconomic level, 69% presented poor adherence Due to inconsistency in taking their antiretroviral treatment, 84% of the patients were coinfected with tuberculosis, the mortality of the patients is closely related to the late diagnosis of the disease, representing 23% of patients who came to the hospital after 15 days after symptoms began, the most frequent clinical manifestations in 47% of the patients were found to present respiratory symptoms. In conclusion, the factors that influenced the triggering of multiorgan failure in patients with Histoplasmosis were the low socioeconomic factor, late diagnosis and poor adherence to antiretroviral treatment.
Histoplasmosis is a fungal disease present in patients with acquired immunodeficiency syndrome, which can develop serious complications, one of them being multi-organ failure. The general objective is to determine the factors that are associated in the development of multiple organ failure in patients with HIV at the Hospital de Infectología Dr. José Daniel Rodríguez Maridueña from January to December of the year 2017 -2019. It is a descriptive, documentary, cross-sectional cohort-type, statistical, observational, non-experimental research. The data used were obtained from the clinical and statistical archive department of said Hospital. The results report that the most frequent age group is patients from 23 to 32 years old, representing 45% of the patients, 81% correspond to men, 76% were related to a low socioeconomic level, 69% presented poor adherence Due to inconsistency in taking their antiretroviral treatment, 84% of the patients were coinfected with tuberculosis, the mortality of the patients is closely related to the late diagnosis of the disease, representing 23% of patients who came to the hospital after 15 days after symptoms began, the most frequent clinical manifestations in 47% of the patients were found to present respiratory symptoms. In conclusion, the factors that influenced the triggering of multiorgan failure in patients with Histoplasmosis were the low socioeconomic factor, late diagnosis and poor adherence to antiretroviral treatment.
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Virus de inmunodeficiiencias humana, Micosis, Histoplasmosis, Hospital de Infectología Dr. José Daniel Rodríguez Maridueña, Cantón Guayaquil, Ecuador