Utilidad de la ecográfia doppler fetal y marcadores bioquícos como predictores de bienestar fetal en colestasis gravídica
No hay miniatura disponible
Fecha
2021
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
La colestasis gravídica o también llamada colestasis intrahepática del embarazo, se caracteriza por la presencia de prurito materno y alteraciones de transaminasas y ácidos biliares totales en suero materno durante la segunda y tercera etapa del embarazo, resolviéndose tras el parto. En esta patología se han estudiado varios factores que intervienen como son los factores genéticos, ambientales y hormonales. Se ha relacionado a esta patología con múltiples efectos adversos perinatales, entre esos la muerte fetal intraútero súbita, el parto pretérmino, líquido amniótico con meconio y el distress respiratorio. Por lo cual nace el interés de identificar si existen parámetros que me permitan determinar el bienestar fetal o si existe algún tipo de sufrimiento fetal, para lo cual se toma en cuenta estudios complementarios como exámenes de laboratorio especialmente los bioquímicos sanguíneos, la ecografía doppler fetal y el registro cardiotocográfico como marcadores que permitan tomar la decisión de interrumpir el embarazo. Además de identificar si existe relación entre valores de transaminasas altas y alteraciones de la ecografía doppler fetal con adversidades perinatales en gestantes con Colestasis gravídica.
OBJETIVO: Determinar la utilidad del doppler fetal, registro cardiotocográfico y marcadores bioquímicos como predictores de bienestar fetal en el diagnóstico de la colestasis gravídica, en el Hospital Alfredo G. Paulson en el período de Julio del 2018 a Septiembre del 2020. DISEÑO DE ESTUDIO: Estudio Observacional, analítico, correlacional, de corte transversal, retrospectivo en un grupo de gestantes con diagnóstico de colestasis gravídica.
La tabulación de los datos se realizó mediante el análisis de los programas de SPSS y hojas de cálculo de Microsoft Excel 2016, para determinar la validez estadística se utilizó un intervalo de confianza del 95% e índice de erros del 5%. Para establecer relación estadística entre variables cualitativas se realizará prueba de Chi cuadrado con variables cuantitativas.
Gravity cholestasis, or also called intrahepatic cholestasis of pregnancy, is characterized by the presence of maternal itching and alterations of transaminases and total bile acids in maternal serum during the second and third stages of pregnancy, resolving after delivery. Several intervening factors have been studied in this pathology, such as genetic, environmental and hormonal factors. This pathology has been associated with multiple perinatal adverse effects, including sudden intrauterine fetal death, preterm delivery, amniotic fluid with meconium, and respiratory distress. Therefore, the interest in identifying if there are parameters that allow me to determine fetal well-being or if there is any type of fetal distress, for which complementary studies such as laboratory tests, especially blood biochemistry, fetal doppler ultrasound and cardiotocographic recording as markers that allow the decision to terminate the pregnancy. In addition to identifying if there is a relationship between high transaminase values and changes in fetal doppler ultrasound with perinatal adversities in pregnant women with cholestasis gravidarum. OBJECTIVE: To determine the usefulness of fetal doppler, cardiotocographic recording, and biochemical markers as predictors of fetal well-being in the diagnosis of gravid cholestasis, at the Alfredo G. Paulson Hospital in the period from July 2018 to September 2020. STUDY DESIGN: Observational, analytical, correlational, cross-sectional, retrospective study in a group of pregnant women diagnosed with cholestasis gravidarum. The data was tabulated by analyzing the SPSS programs and Microsoft Excel 2016 spreadsheets. A 95% confidence interval and a 5% error rate were used to determine statistical validity. To establish a statistical relationship between qualitative variables, a Chi-square with quantitative variables was performed.
Gravity cholestasis, or also called intrahepatic cholestasis of pregnancy, is characterized by the presence of maternal itching and alterations of transaminases and total bile acids in maternal serum during the second and third stages of pregnancy, resolving after delivery. Several intervening factors have been studied in this pathology, such as genetic, environmental and hormonal factors. This pathology has been associated with multiple perinatal adverse effects, including sudden intrauterine fetal death, preterm delivery, amniotic fluid with meconium, and respiratory distress. Therefore, the interest in identifying if there are parameters that allow me to determine fetal well-being or if there is any type of fetal distress, for which complementary studies such as laboratory tests, especially blood biochemistry, fetal doppler ultrasound and cardiotocographic recording as markers that allow the decision to terminate the pregnancy. In addition to identifying if there is a relationship between high transaminase values and changes in fetal doppler ultrasound with perinatal adversities in pregnant women with cholestasis gravidarum. OBJECTIVE: To determine the usefulness of fetal doppler, cardiotocographic recording, and biochemical markers as predictors of fetal well-being in the diagnosis of gravid cholestasis, at the Alfredo G. Paulson Hospital in the period from July 2018 to September 2020. STUDY DESIGN: Observational, analytical, correlational, cross-sectional, retrospective study in a group of pregnant women diagnosed with cholestasis gravidarum. The data was tabulated by analyzing the SPSS programs and Microsoft Excel 2016 spreadsheets. A 95% confidence interval and a 5% error rate were used to determine statistical validity. To establish a statistical relationship between qualitative variables, a Chi-square with quantitative variables was performed.
Descripción
PDF
Palabras clave
Doppler fetal, Colestasis, FACTORES DE RIESGO, EMBARAZO, HOSPITAL DE LA MUJER ALFREDO G. PAULSON, CANTON GUAYAQUIL, ECUADOR