Estudio bibliográfico sobre la actividad antiinflamatoria de la chanca piedra (Phyllanthus niruri) mediante diferentes extractos.
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2021
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
En el presente trabajo de investigación se evaluó cómo actúan los principios activos de la chanca piedra (Phyllanthus niruri) como tratamiento alternativo para combatir afecciones de carácter inflamatorio como la urolitiasis, el cual tiene como objetivo evaluar de forma bibliográfica su actividad antinflamatoria mediante la obtención de diferentes extractos. Debido a que la litiasis renal es una patología a la cual se le atribuye ser la causante de la formación de los cálculos renales en el tracto urinario. Para lo cual se buscó información de diferentes autores, las investigaciones demuestran el uso terapéutico con su acción antiviral y antilítica es viable en aplicaciones clínicas. De aquellos estudios se determina que principalmente los alcaloides como indolizidínicos filantina y nirurina presentes en la hoja de la chanca piedra y poseen propiedades antinflamatorias. De acuerdo a investigaciones realizadas de forma descriptiva y cualitativa obtenidas de diferentes fuentes fidedignas en donde se determinaron los principios activos, mediante ensayos fisicoquímicos y fitoquímicos. Aquellos ensayos revelaron la presencia de alcaloides, así como también terpenos, esteroides, flavonoides, cumarinas y taninos. De acuerdo al artículo científico de Lemus y Ramos para la aplicación en sujetos de prueba se utilizó biomodelos animales con diabetes. Estos estudios determinaron que los resultados fueron positivos ya que se comprobó la presencia de metabolitos secundarios. La presencia de los alcaloides filantina y nirurina resultantes en el extracto de la hoja de chancapiedra mediante su actividad antinflamatoria promueven la relajación uretral lo cual facilita que se eliminen los cálculos renales.
This research work evaluated how the active principles of chancapiedra (Phyllanthus niruri) act as an alternative treatment to combat inflammatory conditions such as urolithiasis. The objective of this study is to evaluate in a bibliographic way its anti-inflammatory activity by obtaining different extracts. Due to the fact that renal lithiasis is a pathology which is attributed to be the cause of the formation of kidney stones in the urinary tract. For which information was compiled from different authors, where research shows the therapeutic use of chanca piedra for its antiviral and antilithiatic action is viable in clinical applications. From those studies it was determined that mainly the alkaloids such as indolizidine, phyllanthine and nirurine present in the leaf of the chancapiedra have anti-inflammatory properties. According to descriptive and qualitative research obtained from different reliable sources where the active principles of chanca piedra were determined by physicochemical and photochemical tests. Those assays revealed the presence of alkaloids as well as terpenes, steroids, flavonoids, coumarins and tannins. According to the scientific article by Lemus and Ramos, those animal biomodels with diabetes were used for the application in test subjects. These studies determined that the results were positive since the presence of secondary metabolites was proved. The presence of the resulting alkaloids phyllanthine and nirurin in the leaf extract of chancapiedra through their anti-inflammatory activity promote urethral relaxation which facilitates the elimination of kidney stones.
This research work evaluated how the active principles of chancapiedra (Phyllanthus niruri) act as an alternative treatment to combat inflammatory conditions such as urolithiasis. The objective of this study is to evaluate in a bibliographic way its anti-inflammatory activity by obtaining different extracts. Due to the fact that renal lithiasis is a pathology which is attributed to be the cause of the formation of kidney stones in the urinary tract. For which information was compiled from different authors, where research shows the therapeutic use of chanca piedra for its antiviral and antilithiatic action is viable in clinical applications. From those studies it was determined that mainly the alkaloids such as indolizidine, phyllanthine and nirurine present in the leaf of the chancapiedra have anti-inflammatory properties. According to descriptive and qualitative research obtained from different reliable sources where the active principles of chanca piedra were determined by physicochemical and photochemical tests. Those assays revealed the presence of alkaloids as well as terpenes, steroids, flavonoids, coumarins and tannins. According to the scientific article by Lemus and Ramos, those animal biomodels with diabetes were used for the application in test subjects. These studies determined that the results were positive since the presence of secondary metabolites was proved. The presence of the resulting alkaloids phyllanthine and nirurin in the leaf extract of chancapiedra through their anti-inflammatory activity promote urethral relaxation which facilitates the elimination of kidney stones.
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CHANCAPIEDRA, FILANTINA, NIRURINA, UROLITIASIS