Grados de fibrosis hepática en pacientes con obesidad y/o diabetes
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2022
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
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Antecedente: La fibrosis hepática es el reemplazo de tejido hepático normal por un tejido fibrótico. Es la secuela de una lesión crónica del hígado que puede ser por diferente etiología. Su prevalencia global es del 25% y su incidencia ha incrementado de forma significativa a nivel mundial hasta el 60-80%, en poblaciones de riesgo con obesidad, sobrepeso, diabetes tipo 2 y síndrome metabólico. Objetivo: Determinar los grados de fibrosis hepática en paciente con obesidad y diabetes mellitus. Metodología: Estudio descriptivo, prospectivo, de corte transversal durante el periodo de 2021 hasta 2022. Población y Muestra: Población 2840 pacientes que acudieron a la consulta externa de gastroenterología con diagnóstico de obesidad y diabetes mellitus durante el periodo de estudio y cumplieron con los criterios de inclusión y exclusión. La muestra corresponderá a 303 pacientes, obtenidos mediante a través del sistema estadístico EPI INFO, con un 95% de nivel de confianza y 5% de precisión. Para este estudio se realizará el estudio de elastografía transitoria a través de fibroscan en los pacientes incluidos en este estudio, y la información obtenida será registrada en una base de datos elaborada en Microsoft Excel y cuyos resultados serán analizados mediante una plataforma estadística SPSS. Resultados: Se confirma que existe una incidencia de la obesidad en la progresión de fibrosis hepática, así como en el hígado graso, más se niega la incidencia de la diabetes en el desarrollo de ambas patologías.
Background: Liver fibrosis is the replacement of normal liver tissue by fibrotic tissue. It is the sequela of a chronic liver injury that can be due to different etiologies. Its global prevalence is 25% and its incidence has increased significantly worldwide to 60-80%, in populations at risk with obesity, overweight, type 2 diabetes and metabolic syndrome. Objective: We will determine the degrees of hepatic fibrosis in patients with obesity and diabetes mellitus. Methodology: A descriptive, prospective, cross-sectional study will be carried out during the period from 2021 to 2022. Population and Sample: The population will be 2840 patients who attended the gastroenterology outpatient clinic with a diagnosis of obesity and diabetes mellitus during the period of study. The sample corresponds to 303 patients, obtained through the EPI INFO statistical system, with a 95% confidence level and 5% precision. For this study, the transient elastography study was be carried out through fibroscan in the patients included in this study, and the information obtained was registered in a database elaborated in Microsoft Excel and whose results were analyzed through a statistical platform SPSS. Results: It is confirmed that there is an incidence of obesity in the progression of liver fibrosis, as well as in fatty liver, but the incidence of diabetes in the development of both pathologies is denied
Background: Liver fibrosis is the replacement of normal liver tissue by fibrotic tissue. It is the sequela of a chronic liver injury that can be due to different etiologies. Its global prevalence is 25% and its incidence has increased significantly worldwide to 60-80%, in populations at risk with obesity, overweight, type 2 diabetes and metabolic syndrome. Objective: We will determine the degrees of hepatic fibrosis in patients with obesity and diabetes mellitus. Methodology: A descriptive, prospective, cross-sectional study will be carried out during the period from 2021 to 2022. Population and Sample: The population will be 2840 patients who attended the gastroenterology outpatient clinic with a diagnosis of obesity and diabetes mellitus during the period of study. The sample corresponds to 303 patients, obtained through the EPI INFO statistical system, with a 95% confidence level and 5% precision. For this study, the transient elastography study was be carried out through fibroscan in the patients included in this study, and the information obtained was registered in a database elaborated in Microsoft Excel and whose results were analyzed through a statistical platform SPSS. Results: It is confirmed that there is an incidence of obesity in the progression of liver fibrosis, as well as in fatty liver, but the incidence of diabetes in the development of both pathologies is denied
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CIRROSIS HEPATICA, SOBREPESO, OBESIDAD, DIABETES MELLITUS, ESTUDIO DESCRIPTIVO, HOSPITAL DE ESPECIALIDADES DR. TEODORO MALDONADO CARBO, CANTON GUAYAQUIL, ECUADOR