Evaluación fisicoquímica in vitro de la capacidad de gastroresistencia y disolución en medicamentos antiulcerosos.
Fecha
2002
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
El diseño de una forma de dosaje de liberación retardada exige pruebas de acción In Vitro de acuerdo con métodos y equipos apropiados a fin de optimizar al máximo la obtención de resultados reales, de tal manera que permitan correlacionarlos con los resultados obtenidos con las pruebas In Vivo. Así una actividad satisfactoria In Vitro podría traducirse a una eficacia terapéutica In Vivo.
Los resultados obtenidos en las diferentes formas de dosaje, en su evaluación In Vitro, tanto del grado de protección del Omeprazol en su paso por el canal gastrointestinal, la capacidad de sesión del principio activo por parte de los microgránulos entéricos en un tiempo determinado, así como la valoración de la potencia o concentración del ingrediente activo, es necesario correlacionarlos con todo cuidado, ya que ellos proveen una guía decisiva que permitirá sacar conclusiones de equivalencias y disponibilidad del ingrediente activo.
The design in a way of dose of slowed liberation demands action tests In agreement Vitro with methods and appropriate teams in order to optimize to the maximum the obtaining of real results in such a way that you/they allow to correlate them with the obtained results of the tests In Alive. This way a satisfactory activity In Vitro could be translated to a therapeutic effectiveness In Alive. The results obtained in the different dose forms, in their evaluation In Vitro, so much of the degree of protection of the Omeprazol in their pass for the gastro-intestinal channel, the surrender capacity of of the active principle on the part of the micro-granulosen a certain time, as well as the valuation of the power or concentration of the active ingredient, are necessary to correlate them with all care, since they provide a decisive guide that allows to take out conclusions of equivalences and readiness of the active ingredient.
The design in a way of dose of slowed liberation demands action tests In agreement Vitro with methods and appropriate teams in order to optimize to the maximum the obtaining of real results in such a way that you/they allow to correlate them with the obtained results of the tests In Alive. This way a satisfactory activity In Vitro could be translated to a therapeutic effectiveness In Alive. The results obtained in the different dose forms, in their evaluation In Vitro, so much of the degree of protection of the Omeprazol in their pass for the gastro-intestinal channel, the surrender capacity of of the active principle on the part of the micro-granulosen a certain time, as well as the valuation of the power or concentration of the active ingredient, are necessary to correlate them with all care, since they provide a decisive guide that allows to take out conclusions of equivalences and readiness of the active ingredient.
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MEDICAMENTOS ANTIULCEROSOS, GASTROENTEROLOGÍA, BIOFARMACIA, FARMACOLOGÍA