Identificación de origen primario de carcinoma metastásico mediante pruebas de inmunohistoquímica en el Departamento de Patología I.O.N. SOLCA 2013 - 2015
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2016
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Existe un ascendente énfasis en el diagnóstico de las metástasis. Para establecerlo, el patólogo presenta una continua y creciente demanda de un diagnóstico acertado y una búsqueda del tumor primario.
Aunque los patólogos están familiarizados con la mayoría de los patrones de metástasis en localizaciones como pulmón, hígado nódulos linfáticos, el cáncer puede metastatizar en lugares infrecuentes como glándula mamaria, bazo, páncreas, glándula tiroides y otros. Este patrón impredecible de metástasis puede acarrear potenciales problemas para los clínicos y patólogos y resultar en errores diagnósticos de la localización primaria de los tumores. Para la asociación de la variedad de patrones metastásicos de las neoplasias, es necesario acortar las probabilidades del origen de estas lesiones. En este estudio, por medio de un panel experimental de inmunohistoquímica (IHQ), se establecerá el origen primario de los carcinomas metastásicos, que neoplasias son las más comúnmente encontradas usando este plan experimental, el impacto sobre la logística médica multidisciplinaria sobre los pacientes con diagnóstico histopatológico de Carcinoma/Adenocarcinoma metastásico y el costo-beneficio de cada paciente en un estudio de esta magnitud.
Esta investigación utilizó el método científico y es de tipo experimental-prospectivo tomándose como universo a los pacientes con diagnóstico histopatológico de Carcinoma/Adenocarcinoma metastásico en el departamento de Anatomía patológica del Instituto Oncológico Nacional – Sociedad de Lucha Contra el Cáncer (ION – SOLCA), teniendo o no antecedentes oncológicos personales (AOP).
El plan de panel experimental en este estudio consta de 5 tinciones en hombres y 6 tinciones en mujeres. Según sus resultados y patrones de tinción se encontraron los resultados esperados.
There is an increasing emphasis in the metastases diagnosis. For that to stablish, pathologist present a continuous and increasing demand for an accurate diagnosis and seek of the primary tumor. Even if pathologists are familiarized with most metastases patterns in sites such as lung, liver and lymph nodes, cancer can sometimes metastatize in unfrequent locations like mammary gland, spleen, pancreas, thyroid gland and others. This unpredictable metastases pattern can bring potential problems for clinical and pathology doctors and result in diagnostic mistakes of the primary site of tumors. For the association of the metastasis patterns variety and the primary neoplasms, it’s necessary to shorten the probabilities of these lesions origins. In this research, by an experimental inmunohistochemestry (IHQ) panel, we will establish the primary origin of the metastatic carcinomas, which neoplasms are the most frequently found using this experimental protocol, the impact over the medical multidisciplinary logistic on the patients with histopathologic diagnose of metastatic carcinoma/adenocarcinoma, and each patient cost-efficacy in a study of this magnitude. The study used the scientific method, and it is an experimental-prospective type taking as universe the patients with histopathologic diagnose of metastatic Carcinoma/Adenocarcinoma in the Anatomo-Pathology department of the National Oncologic Institute – “Sociedad de Lucha Contra el Cancer” (ION-SOLCA), having reported or not, personal oncologic clinical history (AOP). The experimental panel plan in this research counts with 5 stains for men, and 6 stains for women. According to the given results and staining patterns, expected results were found
There is an increasing emphasis in the metastases diagnosis. For that to stablish, pathologist present a continuous and increasing demand for an accurate diagnosis and seek of the primary tumor. Even if pathologists are familiarized with most metastases patterns in sites such as lung, liver and lymph nodes, cancer can sometimes metastatize in unfrequent locations like mammary gland, spleen, pancreas, thyroid gland and others. This unpredictable metastases pattern can bring potential problems for clinical and pathology doctors and result in diagnostic mistakes of the primary site of tumors. For the association of the metastasis patterns variety and the primary neoplasms, it’s necessary to shorten the probabilities of these lesions origins. In this research, by an experimental inmunohistochemestry (IHQ) panel, we will establish the primary origin of the metastatic carcinomas, which neoplasms are the most frequently found using this experimental protocol, the impact over the medical multidisciplinary logistic on the patients with histopathologic diagnose of metastatic carcinoma/adenocarcinoma, and each patient cost-efficacy in a study of this magnitude. The study used the scientific method, and it is an experimental-prospective type taking as universe the patients with histopathologic diagnose of metastatic Carcinoma/Adenocarcinoma in the Anatomo-Pathology department of the National Oncologic Institute – “Sociedad de Lucha Contra el Cancer” (ION-SOLCA), having reported or not, personal oncologic clinical history (AOP). The experimental panel plan in this research counts with 5 stains for men, and 6 stains for women. According to the given results and staining patterns, expected results were found
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Metástasis de la neoplasia, Inmunohistoquímica, Patología, Hospital SOLCA de Guayaquil, Cantón Guayaquil, Ecuador