La hiperinsulinemia como factor de riesgo para la severidad de la psoriasis
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2021
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Universidad de Guayaquil. Facultad de Ciencias Médicas. Carrera de Medicina
Resumen
Introducción: La psoriasis al ser una enfermedad inflamatoria crónica se encuentra relacionada con diversas patologías cuya base se centra así mismo en procesos inflamatorios donde participan células proinflamatorias y que gatillan la gravedad de la enfermedad (psoriasis) ya que aceleran los procesos de alteración en la diferenciación y crecimiento epidérmico junto a alteraciones bioquímicas es e inmunitarias, así como vasculares.
Objetivo: Determinar el estado de la hiperinsulinemia en relación a la severidad de la psoriasis en pacientes atendidos por consulta externa en el Hospital de Especialidades Teodoro Maldonado Carbo durante el periodo enero 2020 - diciembre 2020.
Método: El presente proyecto de investigación será un estudio no experimental de tipo retrospectivo porque la información que se analizará se obtendrá en un periodo posterior al actual; transversal ya que la información obtenida fue dentro de un periodo determinado; descriptivo por ser un estudio en el cual se describen los resultados que se obtendrán a partir de una población en estudio; y observacional ya que no se realizó manipulación y tampoco hubo intervención de las variables obtenidas. A su vez tendrá un enfoque cuantitativo ya que logrará adaptarse de mejor manera según las características y necesidades de la investigación para establecer la relación entre la hiperinsulinemia como factor de riesgo de severidad de la psoriasis.
Resultados: Se tomó en cuenta una población de 162 pacientes quienes fueron atendidos por la consulta externa del servicio de Dermatología del Hospital Teodoro Maldonado Carbo durante el periodo de enero 2020 a diciembre 2020 en el cual se observó que aquello pacientes que presentaron valores de hiperinsulinemia presentaban a su vez una psoriasis con una severidad de moderada/severa (47.53% de la población en estudio) en relación a aquellos pacientes que presentaron valores de insulina basal dentro de los rangos normales (0.62% de la población en estudio).
Conclusiones: La hiperinsulinemia es un factor de riesgo identificable para el desarrollo de una psoriasis con severidad moderada/grave lo cual permite
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determinar la importancia de una correcta y oportuna identificación de los niveles de insulina en los pacientes con psoriasis con la finalidad de determinar un posible comportamiento de la enfermedad en relación a su gravedad.
Introduction: Psoriasis being a chronic inflammatory disease is related to various pathologies whose base is also centered on inflammatory processes involving proinflammatory cells and tigger the Severity of the disease (psoriasis) as they accelerate the processes of alteration in epidermal differentiation and growth along with biochemical and immune, as well as vascular alterations. Objective: To determine the status of hyperinsulinemia in relation to the severity of psoriasis in patients seen for outpatient consultation at the Hospital de Especialidades Teodoro Maldonado Carbo during the period January 2020 – December 2020. Method: The present research project will be a non-experimental study of retrospective type because the information to be analyzed will be obtained in a period subsequent to the current one; transversal since the information obtained was within a determined period; descriptive because it is a study in which the results to be obtained from a population under study are described; and observational since no manipulation was performed and there was no intervention of the variables obtained. At the same time, it will have a quantitative approach since it will be better adapted to the characteristics and needs of the research to establish the relationship between hyperinsulinemia as a risk factor for the severity of psoriasis. Results: A population of 162 patients was taken into account who were seen by the outpatient clinic of the Dermatology service of the Teodoro Maldonado Carbo Hospital during the period from January 2020 to December 2020 in which it was observed that those patients who presented values of hyperinsulinemia presented in turn a psoriasis with a severity of moderate/severe (47.53% of the study population) in relation to those patients who presented basal insulin values within normal ranges (0.62% of the study population). Conclusion: Hyperinsulinemia is an identifiable risk factor for the development of psoriasis with moderate/severe severity which allows determining the importance of a correct and timely identification of insulin levels XXIII in patients with psoriasis in order to determine a possible behavior of the disease in relation to its severity.
Introduction: Psoriasis being a chronic inflammatory disease is related to various pathologies whose base is also centered on inflammatory processes involving proinflammatory cells and tigger the Severity of the disease (psoriasis) as they accelerate the processes of alteration in epidermal differentiation and growth along with biochemical and immune, as well as vascular alterations. Objective: To determine the status of hyperinsulinemia in relation to the severity of psoriasis in patients seen for outpatient consultation at the Hospital de Especialidades Teodoro Maldonado Carbo during the period January 2020 – December 2020. Method: The present research project will be a non-experimental study of retrospective type because the information to be analyzed will be obtained in a period subsequent to the current one; transversal since the information obtained was within a determined period; descriptive because it is a study in which the results to be obtained from a population under study are described; and observational since no manipulation was performed and there was no intervention of the variables obtained. At the same time, it will have a quantitative approach since it will be better adapted to the characteristics and needs of the research to establish the relationship between hyperinsulinemia as a risk factor for the severity of psoriasis. Results: A population of 162 patients was taken into account who were seen by the outpatient clinic of the Dermatology service of the Teodoro Maldonado Carbo Hospital during the period from January 2020 to December 2020 in which it was observed that those patients who presented values of hyperinsulinemia presented in turn a psoriasis with a severity of moderate/severe (47.53% of the study population) in relation to those patients who presented basal insulin values within normal ranges (0.62% of the study population). Conclusion: Hyperinsulinemia is an identifiable risk factor for the development of psoriasis with moderate/severe severity which allows determining the importance of a correct and timely identification of insulin levels XXIII in patients with psoriasis in order to determine a possible behavior of the disease in relation to its severity.
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HIPERINSULINEMIA, FACTORES DE RIESGO, PSORIASIS, ESTUDIOS RETROSPECTIVOS, HOSPITAL DE ESPECIALIDADES DR. TEODORO MALDONADO CARBO, CANTON GUAYAQUIL, ECUADOR