Histoplasmosis sistémica en pacientes con virus de inmunodeficiencia humana y principales métodos diagnósticos utilizados trabajo realizado en el Hospital Dr. José Daniel Rodríguez Maridueña período 2014- 2015
No hay miniatura disponible
Fecha
2016
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Medicina
Resumen
PROBLEMA.
La histoplasmosis progresiva diseminada es una de las principales infecciones oportunistas que presentan las personas que viven con virus del VIH/SIDA, con una prevalencia del 35% en PVVS (personas que viven con virus del VIH/SIDA) hospitalizados, Siendo causa de una elevada morbi-mortalidad, debido a la poca disponibilidad de métodos diagnósticos.
OBJETIVO.
Elaborar un escore de predicción clínica para el diagnóstico temprano de histoplasmosis progresiva diseminada con base a las alteraciones clínicas y de laboratorio encontradas en los pacientes hospitalizados con infección por el virus de inmunodeficiencia humana-1 e histoplasmosis progresiva diseminada.
METODOLOGÍA.
Se realizó un estudio de casos y control de fuente secundaria en todos los pacientes hospitalizados del año 2014 al 2015
RESULTADOS.
Se estudiaron de 100 pacientes, 64 de los cuales tenían el diagnóstico de Histoplasmosis sistemica y el resto fue diagnosticados de cualquier otra infección oportunista asociada a VIH/SIDA: Predomino el sexo masculino (73.89%); El promedio de edad fue de 35.8 años.
Las variables clínicas significativas fueron adenopatías, hepatomegalia y fiebre prolongada, de las cuales se identificó que poseían un excelente poder de confirmación pero un inútil poder de exclusión y Las variables de laboratorio útiles fueron la elevación de fosfatasa alcalina, la trombocitopenia, elevación de LDH.
CONCLUISONES
Al aplicar el modelo de predicción clínica para diagnóstico de Histoplasmosis sistémica
SUMMARY PROBLEM. Progressive disseminated histoplasmosis is one of the main opportunistic infections that present people living with HIV / AIDS, with a prevalence of 35% in PLWHA (people living with HIV / AIDS) Hospitalized, Being cause high morbidity and mortality, due to the limited availability of diagnostic methods. OBJECTIVE. Develop a clinical prediction score for the early diagnosis of progressive disseminated histoplasmosis based on clinical and laboratory abnormalities found in patients hospitalized with virus infection of human immunodeficiency virus-1 and progressive disseminated histoplasmosis. METHODOLOGY. A case study and control of secondary source was performed in all patients hospitalized from 2014 to 2015 RESULTS. We studied 100 patients, 64 of whom had a diagnosis of systemic Histoplasmosis and the rest were diagnosed with any other opportunistic infection associated with HIV / AIDS: predominance of male (73.89%) sex; The average age was 35.8 years. Significant clinical variables were lymphadenopathy, hepatomegaly and prolonged fever, of which it was identified that had an excellent power confirmation but a useless power of exclusion and variables useful laboratory were elevated alkaline phosphatase, thrombocytopenia, elevated LDH. CONCLUISONES In applying the model prediction for clinical diagnosis of systemic Histoplasmosis
SUMMARY PROBLEM. Progressive disseminated histoplasmosis is one of the main opportunistic infections that present people living with HIV / AIDS, with a prevalence of 35% in PLWHA (people living with HIV / AIDS) Hospitalized, Being cause high morbidity and mortality, due to the limited availability of diagnostic methods. OBJECTIVE. Develop a clinical prediction score for the early diagnosis of progressive disseminated histoplasmosis based on clinical and laboratory abnormalities found in patients hospitalized with virus infection of human immunodeficiency virus-1 and progressive disseminated histoplasmosis. METHODOLOGY. A case study and control of secondary source was performed in all patients hospitalized from 2014 to 2015 RESULTS. We studied 100 patients, 64 of whom had a diagnosis of systemic Histoplasmosis and the rest were diagnosed with any other opportunistic infection associated with HIV / AIDS: predominance of male (73.89%) sex; The average age was 35.8 years. Significant clinical variables were lymphadenopathy, hepatomegaly and prolonged fever, of which it was identified that had an excellent power confirmation but a useless power of exclusion and variables useful laboratory were elevated alkaline phosphatase, thrombocytopenia, elevated LDH. CONCLUISONES In applying the model prediction for clinical diagnosis of systemic Histoplasmosis
Descripción
Palabras clave
Histoplasmosis, Virus de inmunodeficiencia humana, Métodos de diagnóstico, Hospital de Infectología Dr. José Daniel Rodríguez Maridueña, Cantón Guayaquil, Ecuador