Influencia del peso y edad del neonato al nacer sobre los valores séricos de 17- hidroxiprogesterona para el cribado de hiperplasia suprarrenal congénita
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2016
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Universidad de Guayaquil. Facultad de Ciencias Químicas
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Se realizó una investigación descriptiva, observacional, analítica no experimental en pacientes neonatos, a los cuales se les aplicó tamizaje de HSC, según Programa Nacional en el Ecuador “Con Pie Derecho” para determinar la relación que existe entre los valores de
17-hidroxiprogesterona con el peso y la edad. Para este estudio se tomaron muestras de sangre del talón a la totalidad de los pacientes que nacieron en la maternidad “Enrique Sotomayor”, en el periodo de enero a marzo del 2016, en el laboratorio clínico INTERLAB S.A. Las muestras fueron procesadas con el método DELFIA® (Dissociation-Enhanced Lanthanide Fluorescent Inmunoassay), procedimiento de fluoroinmunoensayo a tiempo retardado.
Los resultados arrojaron que de los 2774 neonatos nacidos en el periodo de estudio, el
4,7% presentaron valores elevados de 17OHP, que a las 40 semanas de maduración se demostró que los casos confirmados que persistieron con valores anormales fueron de 1,1 caso cada 500 niños nacidos en ese periodo. Además se determinó que existe una asociación estadísticamente significativa entre los valores de 17OHP con la edad gestacional, no encontrándose relación con el peso de los pacientes. No se encontró asociación estadística de los valores de 17OHP con el sexo de los neonatos.
A non- analytic, observational and descriptive investigation was performed in newborn patients, who were applied congenital adrenal hyperplasia (CAH) screening, according to the National Program in Ecuador “Con Pie Derecho”, (With Right Foot), to determine the relationship between the values of 17-hydroxyprogesterone with weight and age. For this study, blood samples were taken from heel to all patients who were born in the maternity hospital “Enrique Sotomayor” in the period from January to March of 2016, in the clinical laboratory INTERLAB S.A. The samples were processed with the DELFIA® method (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay), Time-resolved fluoroinmunoassay procedure. The results launched that of the 2774 borns in the period of study, the 4.7 % presented high values of 17OHP, and to the 40 weeks of maturation showed that the cases confirmed that persisted with abnormal values were 1,1 by each 500 baby born in this period. In addition, it was found that there is a statistically significant association between the values of 17OHP with the gestational age. In addition, there was no relation discovered with patient’s weight. It did not find statistical association of the values of 17OHP with the sex of the newborns.
A non- analytic, observational and descriptive investigation was performed in newborn patients, who were applied congenital adrenal hyperplasia (CAH) screening, according to the National Program in Ecuador “Con Pie Derecho”, (With Right Foot), to determine the relationship between the values of 17-hydroxyprogesterone with weight and age. For this study, blood samples were taken from heel to all patients who were born in the maternity hospital “Enrique Sotomayor” in the period from January to March of 2016, in the clinical laboratory INTERLAB S.A. The samples were processed with the DELFIA® method (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay), Time-resolved fluoroinmunoassay procedure. The results launched that of the 2774 borns in the period of study, the 4.7 % presented high values of 17OHP, and to the 40 weeks of maturation showed that the cases confirmed that persisted with abnormal values were 1,1 by each 500 baby born in this period. In addition, it was found that there is a statistically significant association between the values of 17OHP with the gestational age. In addition, there was no relation discovered with patient’s weight. It did not find statistical association of the values of 17OHP with the sex of the newborns.
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HIPERPLASIA ADRENAL CONGÉNITA, 17-HIDROXIPROGESTERONA, MADURACIÓN GESTACIONAL, NEONATO, VIRILIZACIÓN EN LA MUJER