Determinación de procalcitonina en pacientes con riesgo de sepsis en la Unidad de Cuidados Intensivos Hospital Teodoro Maldonado Carbo 2012-2013
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2016
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Universidad de Guayaquil. Facultad de Ciencias Químicas
Resumen
Cuando la infección no es adecuadamente controlada ocurren una serie de procesos que llevan a estados más graves entre ellos la sepsis. Con la finalidad de demostrar la utilidad de la Procalcitonina (PCT) un biomarcador para el diagnóstico precoz de sepsis, se realizó un estudio observacional, no experimental, retrospectivo, transversal de tipo descriptivo en los pacientes que ingresaron a la unidad de cuidados intensivos del Hospital Teodoro Maldonado Carbo durante el período 2012-2013 y que se encontraban en riesgo de desarrollar sepsis, mediante la revisión de los registros de laboratorio e historias clínicas respectivas. Se encontraron 46 pacientes que cumplieron
con los criterios establecidos de los cuales el 89,46% evidenciaron niveles elevados de PCT compatibles con sepsis. El valor de referencia que mostró mayor sensibilidad fue el de mayor de 10 ng/ml con un 96,4% y un área bajo la curva ROC del 84%. Como conclusión la PCT se perfila como un biomarcador de diagnóstico precoz de sepsis, de elevada sensibilidad, la mayoría de los pacientes que sufrieron de sepsis ingresaron por neumonía lo que también demuestra su utilidad en infecciones de vías respiratorias bajas
When the infection is not properly controlled occurs a number of processes that leads to more serious conditions including sepsis. In order to demonstrate the usefulness of procalcitonin (PCT) a biomarker for early sepsis diagnositc a non- experimental, retrospective, cross-sectional observational descriptive study was conducted in patients admitted to the intensive care unit of Hospital Teodoro Maldonado Carbo during the period 2012-2013 and were at risk of developing sepsis, by reviewing laboratory records and respective medical records. 46 patients who met the criteria of which 89.46% showed elevated levels of PCT were found compatible with sepsis. The benchmark that showed higher sensitivity was greater than 10 ng / ml with 96.4% and area under the ROC curve of 84%. In conclusion, the PCT is emerging as a biomarker for early diagnosis of sepsis, high sensitivity, most patients suffering from sepsis admitted for pneumonia which also demonstrates its usefulness in lower respiratory tract infections
When the infection is not properly controlled occurs a number of processes that leads to more serious conditions including sepsis. In order to demonstrate the usefulness of procalcitonin (PCT) a biomarker for early sepsis diagnositc a non- experimental, retrospective, cross-sectional observational descriptive study was conducted in patients admitted to the intensive care unit of Hospital Teodoro Maldonado Carbo during the period 2012-2013 and were at risk of developing sepsis, by reviewing laboratory records and respective medical records. 46 patients who met the criteria of which 89.46% showed elevated levels of PCT were found compatible with sepsis. The benchmark that showed higher sensitivity was greater than 10 ng / ml with 96.4% and area under the ROC curve of 84%. In conclusion, the PCT is emerging as a biomarker for early diagnosis of sepsis, high sensitivity, most patients suffering from sepsis admitted for pneumonia which also demonstrates its usefulness in lower respiratory tract infections
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Palabras clave
SEPSIS, PROCALCITONINA, BIOMARCADOR, SENSIBILIDAD