Estudio de toxicidad en lotes de venenos de serpientes bothrops de más de un año de almacenamiento
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2011
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Universidad de Guayaquil.Facultad de Veterinaria
Resumen
Al efectuar los análisis de toxicidad de los 15 lotes de venenos de serpientes Bothrops Al efectuar los análisis de toxicidad de los 15 lotes de venenos de serpientes Bothrops se pudo determinar que en los 7 años de almacenamiento registrados de los lotes, se encuentra un desviación estándar global de ±15,26 µg. B. asper presentó una desviación estándar de ±9,79 µg, B. atrox una desviación de ±4,07 µg y B. xanthogramma de 21,42 µg. Los valores más altos de desviación de acuerdo a los años de almacenamiento se registran en el género B. xanthogramma con ±16,22 µg, 16,78 µg y ±19,47 µg a los 5, 4 y 3 años de almacenamiento respectivamente.
El porcentaje de incremento de la dosis letal por año de almacenamiento se encontró a los 2 y 4 años, B. asper con 82,5%, y 62,5% respectivamente. A los 3 y 7 años de almacenamiento en B. xanthogramma con 53,7% y 144,3%. Y a los 5 y 6 años en B. atrox con 39,1% y 91,5%. El mayor incremento porcentual de la dosis letal preestablecida se encontró en DL (50) 45 con el 117,78% y 106,67% en B. asper, en DL (50) 59 µg con el 89,8% y 93,2% en B. atrox, y en DL (50) 68 µg con porcentajes de 2,9% y 5,9% en B. xanthogramma. atrox con 39,1% y 91,5%. El mayor incremento porcentual de la dosis letal prestablecida se encontró en DL (50) 45 con el 117,78% y 106,67% en B. asper, en DL (50) 59 µg con el 89,8% y 93,2% en B. atrox, y en DL (50) 68 µg con porcentajes de
2,9% y 5,9% en B. xanthogramma.
The snake of animal health laboratories "National Institute of Hygiene and Tropical Medicine" Leopoldo Perez Left "city Guayaquil, trials were conducted for the" Lots Toxicity Study in Bothrops snake venoms from more than one storage year ', proposing objectives: determine variations of the median lethal dose (LD 50) in batches of Bothrops snake venom according to storage time and establish the median lethal lethal dose (LD 50) in lots of poisons Bothrops snakes by gender. Taking as an independent variable: the three Bothrops snakes under study (B. asper, B. atrox and B. xanthogramma), and as independent variables: The study of the median lethal dose (LD 50). Upon analysis of cytotoxicity of the 15 batches of Bothrops snake venoms it was determined that in the 7 years registered storage of lots, there is a global standard deviation ± 15.26 mg. B. asper showed a standard deviation of ± 9.79 mg, B. atrox deviation of ± 4.07 mg and B. xanthogramma of ± 21.42 g. Higher values of deviation according to years of storage are recorded in the genus with ± 16.22 mg B. xanthogramma, ± 16.78 ± 19.47 g and g at 5, 4 and 3 years of storage respectively. The percentage increase of the dose lethal by year of storage was found at 2 and 4 years, B. asper with 82.5% and 62.5% respectively. At 3 and 7 years of storage in B. xanthogramma with 53.7% and 144.3%. And at 5 and 6 years in B. atrox with 39.1% and 91.5%. The greatest percentage increase of the preset lethal dose was found in DL (50) 45 to 106.67% 117.78% and in B. asper, in DL (50) 59 mg with 89.8% and 93.2% in B. atrox, and DL (50) 68 mg with rates of 2.9% and 5.9% in B. xanthogramma. The results obtained confirm the hypothesis could be "lots of poisons over a year of storage are not suitable for the development of antivenom" Keywords: Bothrops, B. asper, B. atrox, B. xanthogramma, DL50
The snake of animal health laboratories "National Institute of Hygiene and Tropical Medicine" Leopoldo Perez Left "city Guayaquil, trials were conducted for the" Lots Toxicity Study in Bothrops snake venoms from more than one storage year ', proposing objectives: determine variations of the median lethal dose (LD 50) in batches of Bothrops snake venom according to storage time and establish the median lethal lethal dose (LD 50) in lots of poisons Bothrops snakes by gender. Taking as an independent variable: the three Bothrops snakes under study (B. asper, B. atrox and B. xanthogramma), and as independent variables: The study of the median lethal dose (LD 50). Upon analysis of cytotoxicity of the 15 batches of Bothrops snake venoms it was determined that in the 7 years registered storage of lots, there is a global standard deviation ± 15.26 mg. B. asper showed a standard deviation of ± 9.79 mg, B. atrox deviation of ± 4.07 mg and B. xanthogramma of ± 21.42 g. Higher values of deviation according to years of storage are recorded in the genus with ± 16.22 mg B. xanthogramma, ± 16.78 ± 19.47 g and g at 5, 4 and 3 years of storage respectively. The percentage increase of the dose lethal by year of storage was found at 2 and 4 years, B. asper with 82.5% and 62.5% respectively. At 3 and 7 years of storage in B. xanthogramma with 53.7% and 144.3%. And at 5 and 6 years in B. atrox with 39.1% and 91.5%. The greatest percentage increase of the preset lethal dose was found in DL (50) 45 to 106.67% 117.78% and in B. asper, in DL (50) 59 mg with 89.8% and 93.2% in B. atrox, and DL (50) 68 mg with rates of 2.9% and 5.9% in B. xanthogramma. The results obtained confirm the hypothesis could be "lots of poisons over a year of storage are not suitable for the development of antivenom" Keywords: Bothrops, B. asper, B. atrox, B. xanthogramma, DL50
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SERPIENTES, VENENO, ANIMALES EN CAUTIVERIO