Correlación de la amplitud de distribución de los eritrocitos con la determinación colorimétrica de hierro sérico para diagnóstico de anemia por deficiencia de hierro en pacientes entre 0 y 14 años
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2016
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Universidad de Guayaquil. Facultad de Ciencias Químicas
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La anemia por deficiencia de hierro es el trastorno hematológico más frecuente en la edad pediátrica. Representa un problema grave de salud que afecta a más de una tercera parte de la población mundial. A partir de los datos obtenidos se aplicó la fórmula para determinar ADE, con el objetivo de aportar al diagnóstico de la anemia ferropénica. Se realizó un estudio cuantitativo no experimental, retrospectivo, transversal, en el que se incluyeron 500 niños con orden para estudio de la anemia a los cuales se les tomó una muestra sanguínea venosa, luego de obtener el consentimiento informado de los padres. En la muestra de aquellos que consintieron su participación se realizó biometría hemática que se analizó mediante impedancia, y se determinó hierro sérico por colorimetría, en los equipos automatizados de hematología y bioquímica que se encuentran en las instalaciones del Laboratorio INTERLAB. El 23 % de los niños estudiados hematológicamente, presentaron algún tipo de anemia. El análisis diferencial de casos sospechosos de anemia por deficiencia de hierro arrojó similares resultados ya sea cuando se utiliza como parámetro la concentración de hierro sérico como cuando se realiza el tamizaje mediante el factor de amplitud de la distribución de tamaño eritrocitario. Dando como resultados un 5 % (con la concentración de hierro sérico) y un 4,8 % (con el factor ADE). En ambos tamizajes (hierro vs ADE) se confirmaron 10 (2 %) pacientes con anemia ferropénica. Los parámetros “Concentración de hierro sérico” y “ADE” mostraron que no existe asociación estadística entre ambos.
Iron deficiency anemia is the most common hematological disorder in the pediatric age. It represents a serious health problem affecting more than a third of the world's population. From the data obtained the formula was applied to determine ADE, with the objective of helping the diagnosis of iron deficiency anemia. A non-experimental, retrospective, cross- sectional quantitative study was conducted in which 500 children with an order for the study of anemia were included, who were given a venous blood sample after obtaining the informed consent of the parents. In the sample of those who consented to their participation, blood count was determined by means of impedance and serum iron was determined by colorimetry in the automated hematology and biochemistry equipment at the INTERLAB Laboratory facilities. Twenty-three percent of the hematologically studied children had some type of anemia. The differential analysis of suspected cases of iron deficiency anemia showed similar results when serum iron concentration was used as the parameter when screening was performed using the amplitude factor of the erythrocyte size distribution. The results were 5% (with serum iron concentration) and 4.8% (with ADE factor). In both screenings (iron vs ADE) 10 (2%) patients were confirmed with iron deficiency anemia. The parameters "Concentration of serum iron" and "ADE" showed that there is no statistical association between both.
Iron deficiency anemia is the most common hematological disorder in the pediatric age. It represents a serious health problem affecting more than a third of the world's population. From the data obtained the formula was applied to determine ADE, with the objective of helping the diagnosis of iron deficiency anemia. A non-experimental, retrospective, cross- sectional quantitative study was conducted in which 500 children with an order for the study of anemia were included, who were given a venous blood sample after obtaining the informed consent of the parents. In the sample of those who consented to their participation, blood count was determined by means of impedance and serum iron was determined by colorimetry in the automated hematology and biochemistry equipment at the INTERLAB Laboratory facilities. Twenty-three percent of the hematologically studied children had some type of anemia. The differential analysis of suspected cases of iron deficiency anemia showed similar results when serum iron concentration was used as the parameter when screening was performed using the amplitude factor of the erythrocyte size distribution. The results were 5% (with serum iron concentration) and 4.8% (with ADE factor). In both screenings (iron vs ADE) 10 (2%) patients were confirmed with iron deficiency anemia. The parameters "Concentration of serum iron" and "ADE" showed that there is no statistical association between both.
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ANEMIA, HIERRO, FERRITINA, RETICULOCITOS, HEMOGLOBINA