Evaluación de la gradación original de gleason y la actualización 2014 en cáncer prostático
No hay miniatura disponible
Fecha
2022
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
Universidad de Guayaquil. Facultad de Ciencias Médicas. Escuela de Graduados
Resumen
Antecedentes: La puntuación original de Gleason para pronosticar la evolución del carcinoma de próstata se convirtió en una poderosa herramienta para el urólogo, sin embargo, tras varios años, se han realizado algunas actualizaciones tratando de darle más precisión a los criterios. En 2014 la puntuación original fue actualizada y existe controversia sobre su utilidad.
Objetivo: Evaluar la utilidad de la Gradación original de Gleason y la actualización de 2014 para predecir el estadio clínico en cáncer prostático.
Metodología: Se realizó un estudio cuantitativo, observacional, analítico retrospectivo, que incluyó de manera no aleatoria 96 casos consecutivos con cáncer de próstata atendidos en el hospital de Especialidades “Teodoro Maldonado Carbo”, período 2011 - 2021. Para establecer la correspondencia entre las gradaciones y entre las gradaciones y el estadio clínico se empleó el coeficiente Gamma (γ) y para establecer de la simetría el coeficiente delta de Somers (δS) Se consideraron significativos valores de p < 0,05.
Resultados: El grado de concordancia entre el Puntaje de Gleason Actualización 2014 modificado y el puntaje Original de Gleason mostró valores de γ 0.955, (p 0.000) y δS 0.915 (p 0.000); entre la Gradación de Gleason actualizada 2014 y el estadio clínico coeficiente γ 0.808 (p 0.000) y δS 0.725 (p 0.000); entre la Gradación Original de Gleason y el estadio clínico, valores de γ 0.815 (p 0.000) y δS 0.712 (p 0.000)
Conclusión: La utilidad de la Gradación Original de Gleason es similar a la actualización de 2014 para predecir el estadio clínico en cáncer prostático.
Background: The original Gleason score for prognosticating the development of prostate carcinoma has become a powerful tool for the urologist, however, after several years, some updates have been with the objective of being more precise with the criteria. In 2014 the original score was updated and there have been some controversies about its usefulness. Objective: To evaluate the usefulness of the original Gleason Grading and of the 2014 update to predict clinical status in prostate cancer. Methodology: A quantitative, observational, retrospective analytical study was performed, which included 96 consecutive cases with prostate cancer treated at the "Teodoro Maldonado Carbo" Specialties Hospital, period 2011-2021. The Gamma coefficient (γ) was used to establish the correspondence between the gradations and the clinical status, and the Somers delta coefficient (δS) was used to establish symmetry. Results: The concordance degree between the modified 2014 Updated Gleason Score and the Original Gleason Score showed values of γ 0.955, (p 0.000) and δS 0.915 (p 0. 000); between Gleason Gradation Updated 2014 and the clinical status coefficient γ 0.808 (p 0.000) and δS 0.725 (p 0.000); between Original Gleason Gradation and the clinical status, values of γ 0.815 (p 0.000) and δS 0.712 (p 0.000). Conclusion: The usefulness of the Original Gleason Gradation is similar to the 2014 update for predicting clinical status in prostate cancer.
Background: The original Gleason score for prognosticating the development of prostate carcinoma has become a powerful tool for the urologist, however, after several years, some updates have been with the objective of being more precise with the criteria. In 2014 the original score was updated and there have been some controversies about its usefulness. Objective: To evaluate the usefulness of the original Gleason Grading and of the 2014 update to predict clinical status in prostate cancer. Methodology: A quantitative, observational, retrospective analytical study was performed, which included 96 consecutive cases with prostate cancer treated at the "Teodoro Maldonado Carbo" Specialties Hospital, period 2011-2021. The Gamma coefficient (γ) was used to establish the correspondence between the gradations and the clinical status, and the Somers delta coefficient (δS) was used to establish symmetry. Results: The concordance degree between the modified 2014 Updated Gleason Score and the Original Gleason Score showed values of γ 0.955, (p 0.000) and δS 0.915 (p 0. 000); between Gleason Gradation Updated 2014 and the clinical status coefficient γ 0.808 (p 0.000) and δS 0.725 (p 0.000); between Original Gleason Gradation and the clinical status, values of γ 0.815 (p 0.000) and δS 0.712 (p 0.000). Conclusion: The usefulness of the Original Gleason Gradation is similar to the 2014 update for predicting clinical status in prostate cancer.
Descripción
PDF
Palabras clave
Neoplasias de la próstata, Estudio de casos, Estudio retrospectivos, Hospital de Especialidades Teodoro Maldonado Carbo, Cantón Guayaquil, Ecuador